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Laminins are basement membrane components that regulate a plethora of biological processes. Despite decades of research, the exact roles of laminins in different tissues and in organogenesis remain to be elucidated. Here, we investigated the function of laminin γ1 chain in heart, lung and other tissues by generating a mouse that lacks laminin γ1 in cells expressing SM22α (Tagln) (LMγ1 flox/SM22α C
Introduction: Falls among hospitalized older adults increase morbidity, prolong hospital stays, and raise healthcare costs. Sensor-based technologies and medical devices are emerging tools for fall prevention, but their clinical effectiveness remains uncertain. This systematic review aimed to assess their effectiveness in reducing inpatient falls, staff workload, and physical restraint use in hosp
Background: Signet ring cell (SRC) colorectal cancer is strongly associated with peritoneal metastases (PM), but the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) remains uncertain due to poor prognosis. This study aimed to analyse the prognostic impact of SRCs, assess clinical characteristics, and evaluate the risk of open-close laparotomy. Methods: Thi
Aims: Experimental evidence suggests an important role for sphingosine-1-phosphate (S1P) and its generating enzymes sphingosine kinase 1/2 (SphK1/2) in obesity. We and others have shown that plasma S1P levels are elevated in obese mice and humans. Preclinical studies suggest that genetic SphK2 ablation in mice protects from age- and diet-induced obesity and metabolic dysfunction. We aimed at inves
Background: The coronavirus disease-2019 (COVID-19) pandemic posed pronounced challenges in the care of lung transplant (LTx) recipients. Global variations in containment strategies and the introduction of messenger ribonucleic acid (mRNA) vaccines have sparked extensive debate in both scientific and public arenas. Methods: This retrospective study compared outcomes among LTx recipients in Denmark
Biotechnology is a rapidly progressive field, currently transforming agriculture, healthcare, and life sciences. This rapid development comes with serious legal and ethical challenges as well as risks for human security and health. NATO has prioritized biotechnology and human enhancement technologies for defense, focusing on legitimate, defensive applications. This paper highlights four clusters o
Purpose: To analyse risk of osteoporotic fractures in foreign-born individuals migrating to Sweden at different ages, compared to Swedish-born individuals. Methods: This was a nationwide open cohort study including individuals ≥30 years of age at baseline (N = 4,715,081). Foreign-born individuals were divided as having arrived to and being registered in Sweden from the ages 0–30 years of age or >3
Inom matematik och teknik är det vanligt att behöva lösa komplexa ekvationssystem. Dessa ekvationssystem uppkommer bland annat när man försöker göra simuleringar av till exempel vätskor eller gaser. Dessa ekvationssystem är många gånger mycket svårlösta, vilket innebär att de måste lösas med hjälp av datorer. En algoritm som ofta används till detta ändamål är Newtons metod som stegvis finner bättrIn this bachelor's thesis, different forcing term strategies for the inexact Newton method were evaluated on some standard test problems, the stationary p-Laplacian differential equation and the time-dependent Forchheimer equation. The forcing term strategies were initially studied by replicating experiments conducted by An, Mo and Liu (2005, Journal of Computational and Applied Mathematics)
The invasive oomycete pathogen Aphanomyces astaci significantly threatens native European crayfish populations, prompting investigations towards the effects of protective immunostimulation on the immune response of the vulnerable noble crayfish (Astacus astacus). Here, we evaluate the effect of three oomycete-derived immunostimulant treatments: laminarin (β-1,3-glucan found within the Ap. astaci c
Background Although genetic variants associated with bladder cancer (BCa) risk have been identified through hypothesis-driven and genome-wide association studies, a systematic understanding of BCa genetic susceptibility at the gene and pathway levels remains to be achieved. Materials and methods In this 2-stage functional genomics study, we used 5 independent tools for genome-wide gene mapping and
Global capital is increasingly settling in Vietnam’s ‘socialist-oriented market economy’. Those employed in the outsourced workplace may encounter precarious and insecure working conditions, while women employees may even be subjected to gender-based violence. Drawing on ethnographic data collected in the Industrial Zones of northern Vietnam, this article examines gendered workplace violence and t
Eye movements originally made during memory formation are often spontaneously reproduced during retrieval, even in the absence of visual input, directing gaze back to the locations where goal-relevant episodic information was previously encountered. This behavior, known as gaze reinstatement, is thought to support the reactivation of episodic content associated with those locations (e.g., Johansso
This paper examines the impact of Germany’s 9-Euro-Ticket and itssuccessor, the German Ticket (49 €), on public transportation usage,environmental benefits, and social equity, while exploring the feasibility ofimplementing a similar model in Sweden. The 9-Euro-Ticket, introduced in2022 as a temporary measure to alleviate economic strain from rising energycosts, significantly increased public trans
Globalization and commodification trends in football negatively impact the climate in terms of greenhouse gas emissions from leagues and international tournaments. A significant share of these emissions stem from the flying of teams, staff and fans. Using Norway as a case study, we ask what a national football federation is doing and could be doing to reduce its ecological footprint from air trave
The practices of doctoral education are intricately entangled with technologies. This methodological paper examines the practical concerns involved in doing the analytic work in a networked learning setting with Actor-Network theory (ANT). It is a story about engaging with ANT as a companion in an ethnographic research project on teaching practices in Sweden during the Covid-19 pandemic. The empir
The paper explores what the methodological considerations are for a study of educational practice and networked learning in technologically dense classrooms. The approach of the discussed study is informed by Actor-Network Theory (ANT) (Latour, 2005) and the paper outlines the methodological consequences for adopting principles associated with ANT and post-humanist critiques of representational ep
