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Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.
In this study, the integral pulse frequency modulation model is extended to account for the presence of ectopic beats and heart rate turbulence (HRT). Based on this model, a new statistical approach to the detection and characterization of HRT is presented. The detector structure involves a set of Karhunen-LoEve basis functions and a generalized likelihood ratio test statistic T(x) . The three mos
In this work we perform a high-resolution spectroscopic investigation of Eu3+-Ce3+ and Pr3+-Ce3+ codoped Y2SiO5 crystals. Satellite line spectra were recorded at low temperatures around the Eu3+:F-7(0) -> D-5(0) and the Pr3+:H-3(4) -> D-1(2) transitions. It is observed that the incorporation of Ce3+ as a codopant notably changes the Eu3+ and Pr3+ satellite line patterns. Satellite lines measured i
In most species, males do not abandon offspring or reduce paternal care when they are cuckolded by other males. This apparent lack of adjustment of paternal investment with the likelihood of paternity presents a potential challenge to our understanding of what drives selection for paternal care. In a comparative analysis across birds, fish, mammals, and insects we identify key factors that explain
Fires can be an important hazard for the overall safe operation of nuclear power plants. Prevention of fire, fast detection and efficient extinguishment of a fire are some parameters, which are important to consider when designing the fire safety in a nuclear power plant. As an alternative to extinguishment system the use of hypoxic air or hypoxic air venting has been introduced e.g. in storage ro
For small deformations a crack/interface model that considers general 3D normal and shear loading is proposed. It involves elasticity, plasticity and damage and it is thermodynamically based. An essential feature of the model is its consistency with the concepts behind the fictitious crack model. In particular, no crack deformation occurs before the crack is initiated and when a crack has just bee
Motion estimation in a series of consecutive images is used in a variety of areas, e.g. video compression and investigation of tissue characteristics and organ function in medical images. Several methods exist both for estimating motions on a pixel level, e.g. block-matching in which two blocks in consecutive images are compared by an evaluation metric, and on a sub-pixel level. In this paper, we
Deep sternal wound infection (DSWI) following cardiothoracic surgery is a rare but potentially life-threatening complication with high morbidity and mortality. DSWI is associated with a significant increase in the length of hospital stay and the cost of hospitalization. The socioeconomic impact of DSWI is considerable. Conventional treatment includes reexploration, surgical debridement, mediastin
Socio-technical methods advocate a human-focus analysis that reflects on social and technical factors in the design of organizational systems. The aim of this paper is to report on the experiences of a ST toolbox use in practice by 36 companies. Our findings show that the use of ST toolbox improves companies’ understanding of their job practices and enhance their learning about their business sust
Methane (CH4) emission from boreal, arctic and subarctic wetlands constitutes a potentially positive feedback to global climate warming. Many process-based models have been developed, but high uncertainties remain in estimating the amount of CH4 released from wetlands at the global scale. This study tries to improve estimates of CH4 emissions by up-scaling a wetland CH4 emission model, PEATLAND-VU
This article is devoted to introduce a new class of nonassociative algebras with involution including the class of structurable algebras.
Popular Abstract in Swedish Diabetes mellitus är en samling sjukdomar som karaktäriseras av förhöjt blodsocker. Traditionellt har man delat upp sjukdomen i två former; typ 1 och typ 2 diabetes. Vid typ 1 diabetes förstörs de insulinproducerande β-cellerna i bukspottskörteln av kroppens immunförsvar och sjukdomen debuterar ofta tidigt i livet. Typ 2 diabetes, tidigare ofta benämnd ”åldersdiabetes” Inadequate insulin secretion is a central component in the development of Diabetes Mellitus, resulting from reduced pancreatic β-cell mass, as well as diminished β-cell function. Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate insulin secretion and β-cell mass in rodents during pregnancy and in metabolically challenged states. However, the role of 5-HT in control of insulin rel
Twenty-five comparative cycle assessments (LCAs) addressing food waste treatment were reviewed, including the treatment alternatives landfill, thermal treatment, compost (small and large scale) and anaerobic digestion. The global warming potential related to these treatment alternatives varies largely amongst the studies. Large differences in relation to setting of system boundaries, methodologica
Popular Abstract in Swedish Adenovirus från människa (Ad) används ofta vid genterapi mot cancer, vaccinutveckling och genöverföring. Modifierade Ad5 och Ad2 virus har framgångsrikt använts som cancercelldödande (onkolytiska) agens i experimentella studier som dock inte kunnat överföras till kliniskt bruk av flera skäl, inklusive bristande spridning av virusinfektionen inom tumörvävnaden. De onkolyHuman adenoviruses (Ads) are broadly used in cancer gene therapy, vaccine development and gene delivery. The modified Ad5 or Ad2 viruses have been successfully used as oncolytic agents in pre-clinical studies. However they could not be translated into clinic utility due to a number of limitations including inefficient Ad spread among tumor cells. The cancer cell killing capacity of oncolytic Ad is
During October 2011 several residents and staff members at a long-term care facility (LTCF) for elderly fell ill with respiratory symptoms. Several of the residents required hospitalization and one died. Non-typeable Haemophilus influenzae (NTHi) was identified as the causative pathogen.
The analysis of a small number of patients with atypical chronic myeloid leukemia showing balanced chromosomal translocations has revealed diverse tyrosine kinase fusion genes, most commonly involving FGFR1, PDGFRA, PDGFRB, JAK2, and ABL. We present a case of aCML with a 3q22;21q22-translocation that led to truncation of the receptor-like tyrosine kinase (RYK) gene and its juxtaposition with seque
It has been reported that there is a difference in drug prescription between males and females. Even after adjustment for multi-morbidity, females tend to use more prescription drugs compared to males. In this study, we wanted to analyse whether the gender difference in drug treatment could be explained by gender-related morbidity.
The calcium-dependent transcription factor NFAT was first described as a key player in immune cell regulation. Since then, NFAT signaling has been shown to be crucial for normal vascular development during embryogenesis. This pathway is also an important regulator of cell growth and differentiation in various cell types, however, the functional significance of NFAT in the vasculature is largely un
