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Clinical Trials in Russia: Growing Experience and Revision of Regulations.

Clinical trials of pharmaceuticals have been running in Russia for more than ten years and while it is an attractive location for research, it remains a largely untapped resource as researchers look to expand patient recruitment outside the Western world. While academic sites like Moscow, St Petersburg and Novosibirsk have all gained experience in clinical trials, smaller hospitals in peripheral

Compliance and Post-Agreement Bargaining

Most literature on international cooperation focuses on the phase leading up to the signing of a treaty, while neglecting the dynamics of bargaining in the aftermath of an international agreement. Reviewing existing literature, we find that bargaining theory deals almost exclusively with the pre-agreement phase and that the enforcement and management schools in the study of compliance are predomin

A new liposomal liver-specific contrast agent for CT: first human phase-I clinical trial assessing efficacy and safety

In this first clinical trial liposome-encapsulated iodixanol, CT particles (CTP) were studied. The aims of the present trial were to assess the efficacy of CTP in CT and to determine the safety of different doses of CTP. A total of 47 healthy volunteers were enrolled in the present study. The CTP was administered at doses 10, 30, 70 and 100 mg encapsulated I/kg bw. Efficacy was assessed using sing

Chern numbers for spin models of transition metal nanomagnets

We argue that ferromagnetic transition metal nanoparticles with fewer than approximately 100 atoms can be described by an effective Hamiltonian with a single giant spin degree of freedom. The total spin S of the effective Hamiltonian is specified by a Berry curvature Chern number that characterizes the topologically nontrivial dependence of a nanoparticle's many-electron wave function on magnetiza

Day-to-day variation in oxygen consumption at submaximal loads during ergometer cycling by adolescents

The day-to-day variation in oxygen consumption ((V) over dot O-2) during ergometer cycling by 20 healthy adolescents, 10 females and 10 males, was measured using indirect calorimetry. The two sets of measurements were performed on two consecutive days. Great care was taken to minimize possible disturbing factors. Cycling started at 50 and 100 W for female and male adolescents, respectively. The lo

Hieracium sect. Hieracium in the province of Östergötland, Sweden

77 species of Hieraciurn sect Hieracium known from the province of Ostergotland are treated with standardized descriptions, determination keys and illustrations. Sixty-one species are indigenous, two of these are endemic, and 16 have been introduced accidentally with grass-seed from central Europe. Compared to other south-Swedish provinces, the Hieracium-flora of Ostergotland is very rich in speci

Online and offline algorithms for the time-dependent TSP with time zones

The time-dependent traveling salesman problem (TDTSP) is a variant of TSP with time-dependent edge costs. We study some restrictions of TDTSP where the number of edge cost changes are limited. We find competitive ratios for online versions of TDTSP. From these we derive polynomial time approximation algorithms for graphs with edge costs one and two. In addition, we present an approximation algorit

All-trans retinoic acid-induced expression of bactericidal/permeability-increasing protein (BPI) in human myeloid cells correlates to binding of C/EBP{beta} and C/EBP{varepsilon} to the BPI promoter.

Bactericidal/permeability-inereasing protein (BPI) neutralizes the proinflammatory effects of lipopolysaccharide and is of potential clinical use in the treatment of fulminant Gram-negative infections. BPI is a cationic protein with antibacterial activity stored in azurophil (primary) granules of neutrophil granulocytes. However, the absence of BPI in patients with specific granule deficiency indi

Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease

Five parkinsonian patients were transplanted bilaterally into the putamen and caudate nucleus with human embryonic mesencephalic tissue from between seven and nine donors. To increase graft survival, the lipid peroxidation inhibitor tirilazad mesylate was administered to the tissue before implantation and intravenously to the patients for 3 days thereafter. During the second postoperative year, th

Biomarker selection for detection of occult tumour cells in lymph nodes of colorectal cancer patients using real-time quantitative RT-PCR

Accurate identification of lymph node involvement is critical for successful treatment of patients with colorectal carcinoma ( CRC). Real- time quantitative RT - PCR with a specific probe and RNA copy standard for biomarker mRNA has proven very powerful for detection of disseminated tumour cells. Which properties of biomarker mRNAs are important for identification of disseminated CRC cells? Seven

Factors Controlling Phase Separation in Water-Salt Solutions of DNA and Polycations.

Factors affecting phase separation in water-salt solutions of polyelectrolyte complexes (PECs), formed by DNA and integral or pendant polycations with a quaternary amino group in every monomer unit, have been studied. When no salt was added, quantitative DNA precipitation occurred at a stoichiometric charge ratio, = [+]/[-] 1. In DNA mixtures with poly(N,N'-dimethyldiallylammonium chloride) (PDMDA

Network formation of catanionic vesicles and oppositely charged polyelectrolytes. Effect of polymer charge density and hydrophobic modification

In nonequimolar solutions of a cationic and an anionic surfactant, vesicles bearing a net charge can be spontaneously formed and apparently exist as thermodynamically stable aggregates. These vesicles can associate strongly with polymers in solution by means of hydrophobic and/or electrostatic interactions. In the current work, we have investigated the rheological and microstructural properties of

Poly(styrene-graft-ethylene oxide) as a compatibilizer in polystyrene/polyamide blends

Polystyrene (PS) blends containing a dispersed phase of either polyamide-6 (PA-6) or polyamide-12 (PA-12) were compatibilized by additions of 1, 3, or 5 wt % poly(styrene-graft-ethylene oxide). The graft copolymers were found to have a stabilizing effect on the domain sizes. Weight average radii of PA-6 domains in compression molded samples were reduced by a factor of 5 with 3 wt % graft copolymer

Evaluating the Seriousness of Disasters: An Empirical Study of Preferences

In making societal decisions concerning hazards with potentially disastrous consequences it is important to have soundly based knowledge of how people evaluate the seriousness of disasters. In the present study a group of students evaluated the seriousness of disasters described in terms of four basic attributes (and their ranges): number of fatalities (0-1000), number of serious injuries (0-4000)

Paul's missionary duty towards Gentiles in Rome: A note on the punctuation and syntax of Romans-I,13-15

Although scholars have long been aware of syntactical difficulties in Rom 1.1315, few have approached the problem by challenging the established punctuation. Readings of the text by some earlier interpreters, e.g. Origen of Alexandria, indicate that there may be good reasons to do so. In this article it is argued that current readings of Rom 1.1315 are based on inaccurate punctuation and syntax. A

Uncertainty in visual processes predicts geometrical optical illusions

It is proposed in this paper that many geometrical optical illusions, as well as illusory patterns due to motion signals in line drawings. are due to the statistics of visual computations. The interpretation of image patterns is preceded by a step where image features such as lines, intersections of lines, or local image movement must be derived. However, there are many sources of noise or uncerta

Report of an international survey of molecular genetic testing laboratories

Objective: To collect data on the practices of molecular genetic testing (MGT) laboratories for the development of national and international policies for quality assurance (QA). Methods: A web-based survey of MGT laboratory directors (n = 827; response rate 63%) in 18 countries on 3 continents. QA and reporting indices were developed and calculated for each responding laboratory. Results: Laborat