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Living organisms need to regulate their gene expression in response to environmental signals and internal cues. This is a computational task where genes act as logic gates that connect to form transcriptional networks, which are shaped at all scales by evolution. Large-scale mutations such as gene duplications and deletions add and remove network components, whereas smaller mutations alter the con
Diabetic retinopathy (DR) is the most feared complication of diabetes with an overall prevalence of 21.9-36.8% and may, if untreated, lead to severe visual disability or blindness. DR is histologically characterized by pericyte and endothelial cell loss, formation of acellular vessel strands, micro-occlusions, progressive ischemia, and finally the appearance of neovascularization and fibrosis. Hyp
Background: The orally active quinoline-3-carboxamide tasquinimod [ABR-215050; CAS number 254964-60-8), which currently is in a phase II-clinical trial in patients against metastatic prostate cancer, exhibits anti-tumor activity via inhibition of tumor angiogenesis in human and rodent tumors. To further explore the mode of action of tasquinimod, in vitro and in vivo experiments with gene microarra
We estimated costs associated with injuries to hands from log splitters and circular saws used to cut up firewood and assessed the value of prevention. The study was carried out as a cost of illness study with an incidence approach based on 57 consecutive patients (median age 51; range 8--81) with injuries to the hand or forearm. Twenty-six of the 57 had an amputation which required microsurgery a
Popular Abstract in Swedish Tuberkulos (tbc) är en av de sjukdomar som sedan tusentals år orsakat mest lidande för mänskligheten. Mycobacterium tuberculosis är den bakterie som orsakar tbc hos människor. Att vi lever tätare inpå varandra på grund av växande befolkning globalt gör att denna luftburna smitta kan fortleva. Fattigdom och undernäring är viktiga bidragande orsaker som förklarar varför dRapid, accurate diagnosis and management of TB in HIV-positive individuals is critical for the success of antiretroviral treatment programmes in primary health care in Sub-Saharan Africa. These studies aim to develop and evaluate methods for TB case finding in adults receiving care at Ethiopian health centres. The prevalence of active TB in a prospective cohort of 812 HIV-positive adults was deter
We present first-principles calculations of x-ray absorption spectra of graphene and hexagonal BN monolayer on the Ni(111) substrate. Including dynamical core-hole screening effects according to the theory of Mahan-Nozieres-de Dominics (MND) results in an overall good agreement with previously published experimental data and our new observations. This approach provides a unified first-principles d
Ulcerated diabetic foot is a complex problem. Ischaemia, neuropathy and infection are the three pathological components that lead to diabetic foot complications, and they frequently occur together as an aetiologic triad. Neuropathy and ischaemia are the initiating factors, most often together as neuroischaemia, whereas infection is mostly a consequence. The role of peripheral arterial disease in d
The elderly population is increasing and with advanced age comes a higher risk for contracting diseases and excessive medicine use. Polypharmacy can lead to drug-related problems and an increased need of health care. More needs to be done to help overcome these problems. In order for new models to be successful and possible to implement in health care they have to be accepted by caregivers. The ai
Smoke from biomass combustion has been identified as a major environmental risk factor associated with adverse health effects globally. Deposition of the smoke particles in the lungs is a crucial factor for toxicological effects, but has not previously been studied experimentally. We investigated the size-dependent respiratory-tract deposition of aerosol particles from wood combustion in humans. T
Background: Treatment decisions can be difficult in men with low-risk prostate cancer (PCa). Objective: To evaluate the ability of a panel of four kallikrein markers in blood-total prostate-specific antigen (PSA), free PSA, intact PSA, and kallikrein-related peptidase 2-to distinguish between pathologically insignificant and aggressive disease on pathologic examination of radical prostatectomy (RP
Popular Abstract in Swedish Patienter med diabetes kan inte kontrollera blodsockernivåerna på grund av att de saknar insulinproducerande celler eller har icke fungerande insulinproducerande celler. Det finns olika typer av diabetes där typ 1 diabetes och typ 2 diabetes är de vanligaste formerna. Den mest framgångsrika behandling mot typ 1 diabetes är transplantation av insulinproducerande celler, Diabetes - the imbalance in glucose homeostasis is partially caused by loss or dysfunction of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce insufficient amounts of insulin or the insulin cannot be used adequately. So far, the most promising therap
This study is centred around different aspects of Boris Pasternak's early poetry that jeopardize semantic coherency and interpretation of his poems. Special attention is paid to metaphors, metonymies, lexical multiplicity (that is a multiplicity of relevant meanings codified in a dictionary) and obscure syntactic connections and how these aspects are combined in his poems. For this purpose the stu
Review of Claes Wahlöö, "Skånes kyrkor 1050-1949" (2014)
Background/Objectives:Considering the importance of glucose as a brain substrate, the postprandial rate of glucose delivery to the blood could be expected to affect cognitive functions. The purpose was to evaluate to what extent the rate of glucose absorption affected measures of cognitive performance in the postprandial period. In addition, cognitive performance was evaluated in relation to indiv
Two studies of testing practices for software product lines identify gaps between required techniques and existing approaches in the available literature. This Web extra offers extra details for the main article (specifically, the bibliography for the two studies described).
