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The catalytic module of Hypocrea jecorina (previously Trichoderma reesei) Cel7B was homologously expressed by transformation of strain QM9414. Post-translational modifications in purified Cel7B preparations were analysed by enzymatic digestions, high performance chromatography, mass spectrometry and site-directed mutagenesis. Of the five potential sites found in the wild-type enzyme, only Asn56 an
We investigate the existence of positive solutions vanishing as x ->+infinity to the semilinear elliptic equation Delta u + f (x, u) + g(x)x . del u = 0, x > A > 0, in R-n, n >= 3, under mild assumptions on the functions f, g. Conditions for these solutions to be radial are also given.
Cells infected with herpes simplex virus type 1 (HSV-1) express a cell surface receptor able to bind the Fc portion of immunoglobulin G (IgG). Of the four human IgG subclasses, the HSV-1 Fc receptor, like staphylococcal protein A, binds to all except IgG3. In this paper, we describe the binding of a number of animal IgG and IgG subclass molecules to HSV-1-infected cells and compare this binding to
Observations of mercury lines in the HgMn stars chi Lupi and HR 7775 made with the Hubble Space Telescope Goddard High Resolution Spectrograph are presented and analyzed. In chi Lupi we find that all observed lines are consistent with the same isotopic mixture (essentially pure (204)Hg). Strong ionization anomalies are present, with UV Hg I lines being too weak and Hg III lines too strong for the
The aim of this study was to investigate why some people will and can work until they are 65 year or more, and some people not either can or will. The study was built at answers from 2 000 employees within the health and medical care services. The data material was divided into three groups from the answers. Group 1 who cannot and will not work until 65 years. Group 2 who can and will work until 6
Dynamical and statistical fragment emission processes in 200 A MeV Ne-20 + Ar-40 collisions are well probed by measurements of charge (Z), mass (A) and momentum vector ((p) over right arrow) of all fragments in large parts of the available momentum space. We present such data obtained at the cluster-jet target of the CELSIUS storage ring, for the first time with an internal, ultra-high vacuum (UHV
”Skjerming” är en psykiatrisk behandlingsmetod som enligt avhandlingsförfattaren inte finns i Sverige. Jag försvenskar här metoden till skärming: I Norge och Danmark skärmar man psykiatripatienter. Metoden består helt enkelt i att man isolerar patienter på psykiatriska avdelningar. Till skillnad från vid isolering finns det personal tillgänglig under hela den tid patienten är skärmad. Det finns sk
Artikeln beskriver och analyserar alternativa sätt att använda sig av Balancerat styrkort inom en rad olika verksamheter inom hälso och sjukvård.
The objective of this study was to increase the knowledge of local stakeholders' acceptance of model-generated data when used as a communication tool in water quality management. The Ronnea catchment in the southwest of Sweden was chosen as the study area. The results indicate the model-generated data served as a uniting factor. Simultaneously, the stakeholders were concerned with presented data,
In decapod crustaceans, the largest density and diversity of sensilla, referred to as setae, is in general found on the mouthparts, but little is known about their sensory properties and thereby their functions. Here data are presented from mechanoreceptors from the two largest mouthparts, maxilliped 2 and 3, of the European shore crab Carcinus maenas. The mechanoreceptors were found to respond to
The molybdenum cofactor (Moco)-containing enzymes are divided into three classes that are named after prototypical members of each family, viz. sulfite oxidase, DMSO reductase and xanthine oxidase. Functional or structural models have been prepared for these three prototypical enzymes: (i) The complex [MoO2(mnt)2]2− (mnt2−=1,2-dicyanoethylenedithiolate) has been found to be able to oxidize hydroge
It has been previously suggested that leukotriene-induced Ca2+ signalling is mediated through a Rho-dependent process, but neither direct activation of Rho nor a mechanism underlying such signalling has been reported. Accordingly, we used the Rhotekin binding assay to assess RhoA activation in intestinal epithelial cells and observed that RhoA was activated by leukotriene D4 (LTD4). We also found
The effect of salt on the location and structure of a flexible polyelectrolyte confined inside a viral capsid and the Donnan equilibrium of the salt across the capsid have been examined using a coarse-grained model solved by Monte Carlo simulations. The polyelectrolyte was represented by a linear jointed chain of charged beads, and the capsid was represented by a spherical shell with embedded char
Objectives. Infliximab is an anti-tumour necrosis factor-alpha (TNF-alpha) mousehuman IgG1/k antibody used to treat patients with rheumatoid arthritis (RA) and other inflammatory diseases. Unfortunately, response failure and side-effects due to immunogenicity of the drug are not rare. In this study, we have compared different methods of assessing drug levels and anti-infliximab antibodies (Abs) an
