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The dissertation is a case study, the topic of which was a participant-oriented research project in which a development programme for support to parents and care of young people was to be implemented in the organization and the concrete social work was developed and changed through researcher-supported intervention. The project was part of a large-scale effort for change and development carried ou
CASCADE is a full hadron level Monte Carlo event generator for ep, gammap and p (p) over bar processes, which uses the CCFM evolution equation for the initial state cascade in a backward evolution approach supplemented with off-shell matrix elements for die hard scattering. A detailed program description is given, with emphasis on parameters the user wants to change and common block variables whic
Formation of germ tubes by Candida albicans has been assumed as a putative virulence factor. Local anesthetics (LAs), e.g., lidocaine and bupivacaine, are known to inhibit germ tube formation. The study confirmed this observation for the novel drug ropivacaine, although it was less potent than the former two drugs. Hypothesizing that the effect is due to blockading ionic channels, we exposed Candi
This thesis is based on four papers (A-D) treating filtering, smoothing, and maximum likelihood (ML) estimation in general state space models using stochastic particle filters (also referred to as sequential Monte Carlo (SMC) methods). The aim of Paper A is to study the bias of Monte Carlo integration estimates produced by the so-called bootstrap particle filter. A bound on this bias which is inv
High-resolution palynofloral signatures through the Cretaceous-Palaeogene boundary succession show several features in common with the Permian-Triassic transition but there are also important differences. Southern Hemisphere Cretaceous-Palaeogene successions, to date studied at high resolution only in New Zealand, reveal a diverse palynoflora abruptly replaced by fungi-dominated assemblages that a
A systematic spectroscopic study of single ZnWO4 :Fe crystals with different iron concentrations has been performed under excitation by ultraviolet light, by synchrotron radiation or under photostimulation by near-infrared light. The luminescence of Fe3+-related centres has been studied. It is shown that iron centres of different types efficiently promote the formation of crystal defects at low te
Strategies for the preparation of multinuclear complexes containing homoditopic and heteroditopic ligands based upon 2,2$-bipyridine (bpy) and 2,2:6$,2$$-terpyridine metal binding domains are presented. Both conventional approaches based upon preparation of a free ligand and subsequent coordination and metal-directed reactions of coordinated ligands are utilized in the various strategies. A repres
Objective. To evaluate the Cockcroft - Gault (CG) equation, using various body weight expressions, and the Sawyer equation in predicting glomerular filtration rate (GFR) using an enzymatic and zero-calibrated Jaffe plasma-creatinine assay, and to derive a new robust equation in adults. Material and methods. The CG weight measures included total, ideal and adjusted body weight (ABW; lowest of total
Ultra-fast time-delayed techniques have been recently applied in a number of studies where exotic nuclei were identified using advanced selection techniques. These include large Compton-suppressed Ge arrays, in-flight separators or recoil separators. Some of the new results are discussed in this presentation. Besides the results for Mg-32 and Pd-96, they include the first determination of the half
This report summarises the first phase of the project “Economic optimization of the industrial fire protection”. Results from the initial phase, along with suggestions for further research are presented.
Childhood asthma and wheeze is more common among boys than girls, white the opposite is found in adults. The main objective was to study the incidence and the course of wheeze and asthma during adolescence with focus on gender differences. In addition, we explored associations between lifestyle factors at baseline and wheeze at follow-up. A total of 2399 adolescents answered validated questionnair
Proteoglycans are well-known modulators of intercellular communication and signaling. Remodeling of the proteoglycans in the human uterus occurs throughout pregnancy, and during labor. We therefore hypothesize that heparan sulfate proteoglycans (HSPGs) play an important role in establishing normal labor. In this study HSPGs were characterized and localized in human uterine tissue. Uterine biopsies
Popular Abstract in Swedish Förekomsten av fetma ökar lavinartat över hela världen, Sverige inte undantaget, och detta är en stor bidragande orsak till att antalet fall av typ 2 diabetes tilltar på ett liknande sätt. Både fetma och typ 2 diabetes är sjukdomar med ett komplicerat mönster av samverkande genetiska och miljömässiga faktorer. Drabbade individer har en klart ökad risk att drabbas av hjäThe worldwide prevalence of obesity and type 2 diabetes is increasing rapidly. Both disorders depend on genetic and environmental factors. The studies included in this thesis investigated the possible association of the FOXC2 and CAPN10 genes with obesity, insulin resistance, type 2 diabetes, and related phenotypes. FOXC2 encodes a forkhead transcription factor, which was identified as a key regul
The use of energetic ion beams for the analysis of materials has been developed throughout the last four decades and has now evolved into a mature and powerful analytical set of tools applicable in great variety of fields. This paper summarises this development with a special emphasis on the use of nuclear microprobes. The main techniques used for ion beam analysis will be described, suitable appl
