With the human genome in a first sequence draft and several other genomes being finished this year, the existing information gap between genomics and proteomics is becoming increasingly evident. The analysis of the proteome is, however, much more complicated because the synthesis and structural requirements of functional proteins are different from the easily handled oligonucleotides for which a f

Picolinic acid (PA) protects against quinolinic acid- and kainic acid-induced neurotoxicity in the brain. To study the uptake of PA to the brain, we administered [H-3]PA via a unilateral nasal instillation or iv injection to mice. Autoradiography demonstrated a rapid uptake of radioactivity in the olfactory nerve layer and in the ipsilateral olfactory bulb (OB) following nasal instillation of [H-3

The isoscalar dipole (compression) mode is studied first using the schematic harmonic-oscillator model, and then the self-consistent Hartree-Fock (HF) and random-phase approximation (RPA) are solved in coordinate space. Taking Pb-208 and the SkyM* interaction as a numerical example, the spurious component and the strength in the continuum are carefully examined using the sum rules. It is pointed o

This report describes the derivation of a nonlinear model of a tractor-semitrailer combination vehicle. The purpose of the model is validation of yaw-control algorithms. The model include 4 DOF in lateral, longitudinal, and yaw motion. It is formulated as a state-spece model with 5 state variables. Additional states are added with the rotational dynamics of the wheels. The model includes a static

A scoring system could be used in all situations where grading of deep leg vein thrombosis (DVT), including mapping of its distribution, is needed. It should also be used in epidemiological studies of DVT in further analysis of different risk groups suffering from DVT. Several scoring systems have been developed during the last three decades but have resulted in various complex and impractical sys

Popular Abstract in Swedish Resenärernas värderingar av kvalitet i lokal kollektivtrafik – hur man kan mäta dem, hur de varierar och hur man kan använda dem i planeringen Syftet med arbetet har varit att ta fram ett mer detaljerat underlag för planering av lokal kollektivtrafik. Med mer kunskap om hur olika grupper av resenärer värderar olika delar av en kollektivtrafikresa kan kollektivtrafiknätThe aim of this work was to get a more detailed basis for planning of local public transport. With more knowledge of how segments of travellers assess different parts of a journey, bus routes can be planned to fit either all passengers or selected groups better. It will also be possible to evaluate perceived travel utility separately for each category of passengers. Stated Preference questionnaire

Surveillance of group A streptococcal (GAS) infections was undertaken as a major component of the European Commission-funded project on severe GAS disease in Europe (strep-EURO). One aim of strep-EURO was to improve the quality of GAS characterization by standardization of methods. An external quality assurance study (EQA) was therefore carried out to evaluate current global performance. Eleven st

The wobbling excitations in the presence of an appreciable amount of alignment are expected to appear more easily at lower angular momenta of the yrast spectra, compared with those in the textbook example. The large B(E2;I-->I-1) value for Delta(n) over cap =1 transitions where (n) over cap expresses the number of wobbling phonons is shown to be a strongly increasing function of the triaxiality pa

The adsorption of a single and negatively charged polyion with varying flexibility onto a surface carrying both negative and positive charges representing a charged membrane surface has been investigated by using a simple model employing Monte Carlo simulations. The polyion was represented by a sequence of negatively charged hard spheres connected with harmonic bonds. The charged surface groups we

Extremal control of Wiener type processes is considered. These modelsconsists of a linear part followed by a static nonlinearity. We will considernonlinearities having one extremum point. The purpose is tokeep the output of the process as close as possible to the extremum point.The main problem in the control of this kind of processesis the non-uniqueness of the inverseof the nonlinearity. This ca

Resurgence of microbialites and anachronistic facies in the aftermath of Phanerozoic extinction events has hitherto only been documented among the "major five." Based on the classical Silurian carbonate platform strata of Gotland, Sweden, a "minor" biotic event is herein for the first time related to a substantial increase in anachronistic facies. Strata deposited during and shortly after the Lau

Recently, common noncoding variants in the TCF7L2 gene were strongly associated with increased risk of type 2 diabetes in samples from Iceland, Denmark, and the U.S. We genotyped 13 single nucleotide polymorphisms (SNPs) across TCF7L2 in 8,310 individuals in family-based and case-control designs from Scandinavia, Poland, and the U.S. We convincingly confirmed the previous association of TCF7L2 SNP