Despite the clinical development of novel adjuvant and neoadjuvant chemotherapeutic drugs, metastatic breast cancer is one of the leading causes of cancer-related death among women. The present review focuses on the relevance, mechanisms, and therapeutic potential of targeting WNT5A as a future anti-metastatic treatment strategy for breast cancer patients by restoring WNT5A signaling as an innovat

Importance: Childhood appendicitis is commonly complicated by gangrene and perforation, yet the causes of complicated appendicitis and how to avoid it remain unknown. Objective: To investigate whether children with IgE-mediated allergy have a lower risk of complicated appendicitis. Design, Setting, and Participants: This retrospective cohort study included all consecutive patients younger than 15

Previous research has made three parallel but incompatible observations on the contemporary development of welfare professions: loss of professional autonomy, hybridization, and maintained autonomy. Yet, research providing contextual understanding of the simultaneous occurrence of these three observations is lacking. The aim of this theoretical paper is to identify and explain seemingly contradict

Cellulose nanocrystal (CNC) incorporation in polymeric matrices is an environmentally friendly approach to mechanical reinforcement. In general, significant mechanical reinforcement can only be achieved by means of good CNC dispersion at random orientation. These primary characteristics are even more relevant for the preparation of nanocomposites based on hydrophobic matrices, such as poly(ε-capro

The extraction, supply, market price and recycling of the metals molybdenum and rhenium were modelled using an integrated system dynamics model. The resource estimates made here resulted in significantly larger estimates than earlier studies for molybdenum. Present molybdenum resources are about 75–80 million ton and about 7 million ton has been mined to date. The ultimately recoverable resources

Due to the limited cooling capacity of air, large-scale proton exchange membrane (PEM) fuel cell stacks are generally cooled by liquid cooling where liquid water is circulated through the flow channels of cooling plates. Effective cooling is essential for the stability, durability, and performance of PEM fuel cells. In this study, cooling plates with conventional straight channel and novel non-uni

To study the intergenerational dynamics of productivity, social mobility and demographic change of any contemporary society is a challenge. To do this for a pre-industrial society at the southern tip of Africa seems almost impossible. Yet this is the purpose of the Cape of Good Hope Panel, an annual panel data set–still under construction–of Cape Colony settler tax records over almost two centurie

Background: Venous thromboembolism (VTE) is the third most frequent life-threatening cardiovascular disease with an annual incidence rate of 1-2 per 1000 person-years. After the diagnosis for primary VTE, about 20-30% patients develop a recurrence within 5-years. VTE recurrence can be prevented by anticoagulants, albeit at the risk of severe bleeding. Heritability of VTE is high and hereditary fac

Every type of reality belongs to the semiotic realm and this means that every being is in constant need of translation and interpretation. What we mostly translate are signs and that is why this book envisages interpreting the morphotic nature of signs. In spite of Roman Jakobson having outlined the impossibility of full equivalence between code-units, the same theoretician admitted to paraphrasin

Report developed for Tourism Tropical North Queensland in connection with the Newscorp Tourism Innovation Conference held in Cairns, Australia 6 November 2015. The report describes elements of innovation theory and practice, as well as the main themes elaborated in the keynote presentations at the conference.

Innovation is essential in the complex and fluid social environment of tourism; for the practitioner, the essential capability is that of being able to learn and innovate, and to do so often. One must therefore reflect on how present methods of university education might equip tourism students (or indeed students in any social science) to develop the necessary innovation capability so as to meet t

Majoriteten av iranierna i Sverige reser ofta till Iran, vilket gör att de enkelt är måltavlor för den islamiska regimen som kan använda sig av dem för att samla in information om andra iranier i Sverige, skriver Ardavan Khoshnood.The majority of Iranians in Sweden often travel to Iran, making them easy targets for the Islamic regime which can use them to gather information about other Iranians in Sweden, writes Ardavan Khoshnood.

Emergency physician Ardavan Khoshnood reacts strongly to Lorentz Tovatts (MP) statement that there are reasons for adults not to use bicycle helmets.

Jag vill gärna avsluta med att citera psykiatrikern David Eberhard som i sin bok ”Det stora könsexperimentet" förklarar problemet med klagomålen kring Hesslow mycket väl: ”I dagens genusteoretiska värld tycks inte ens biologi existera. Man har helt enkelt valt bort den”.A debate article on the discussions at Lund University regarding Professor Germund Hesslow and his lecture regarding sexuality.

The unemployed in Sweden today have to relate to several types of benefit schemes. Apart from the public unemployment insurance program, different workplaces are covered by different complementary benefit arrangements regulated by collective agreements between employer and union organizations. These Employment Transitional Agreements have existed since the 1970s but have expanded further in scope

This paper examines whether and, if so, why source country heterogeneity exists in foreign direct investment. Using detailed Swedish matched employer-employee data for the period from 1996 to 2009, we find statistical evidence that affiliate performance differs systematically across source countries. We then show that differences in foreign multinational enterprises’ global management practices (e

he traditional Swedish monocentric and uniform legal model is challenged by an increasingly diverse contemporary legal situation associated with the development of a multicultural and pluralistic society. How Swedish criminal courts handle this in terms of understanding and framing minority legal culture is addressed by looking into what role is given to this culture in the courts’ construction of

Resistivity measurements in marine environments have already been tested in Norwegian landscapes in in the detection of subsea fracture zones (Lile et al. 1994; Dalsegg, 2012). Yet, most of the produced data have been processed without taking into account the special conditions created by the presence of seawater. Similar studies outside of Norway (Tsourlos et al., 2001; Satriani et al., 2011; Ruc

Aims To determine whether supplemental oxygen in patients with ST-elevation myocardial infarction (STEMI) impacts on procedure-related and clinical outcomes. Methods and results The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction (DETO2X-AMI) trial randomized patients with suspected myocardial infarction (MI) to receive oxygen at 6 L/min for 6-12 h or ambient air. In t