The Adverse Outcome Pathways (AOPs) framework is pivotal in toxicology, but the, terminology describing Key Event Relationships (KERs) varies within AOP guidelines.This study examined the usage of causal, observational and predictive terms in AOP, documentation and their adaptation in AOP development. A literature search and text, analysis of key AOP guidance documents revealed nuanced usage of th

Dopaminergic (DA) neurons exhibit significant diversity characterized by differences in morphology, anatomical location, axonal projection pattern, and selective vulnerability to disease. More recently, scRNAseq has been used to map DA neuron diversity at the level of gene expression. These studies have revealed a higher than expected molecular diversity in both mouse and human DA neurons. However

Stem cell therapies for Parkinson's disease are at an exciting time of development, and several clinical trials have recently been initiated. Human pluripotent stem cells are differentiated into transplantable dopamine (DA) progenitors which are proliferative at the time of grafting and undergo terminal differentiation and maturation in vivo. While the progenitors are homogeneous at the time of tr

This thesis concerns control of capacity-constrained networks. These systems involve many agents interconnected by a resource distribution network. The capacity to generate and distribute this resource is constrained. This applies, for instance, to power grids, communication networks, smart surveillance camera networks, and district heating networks. District heating networks in particular are the

Climate change is causing an intensification of soil drying and rewetting events, altering microbial functioning and potentially destabilizing soil organic carbon. After rewetting, changes in microbial community carbon use efficiency (CUE), investment in life history strategies, and fungal to bacterial dominance co-occur. Still, we have yet to generalize what drives these dynamic responses. Here,

Performance designed around a harbour tour in the Copenhagen harbour. The concept, idea and staging was done by Erik Pold and Adelaide Bentzon, the artistic directors of Public Performance. 5 performers where the main characters in the boat or along the harbour, together with 20 extras, and live electronic music. The performance takes a critical view on how the contemporary harbour area has develo

Introduction:Knowledge about long-time residual symptoms, disabilities, and psychological health in complex regional pain syndrome (CRPS) is limited.Objectives:The aim was to evaluate outcome, focusing on physical symptoms, disability, and psychological health, in individuals with CRPS through a cross-sectional survey study.Methods:Individuals with a confirmed diagnosis of CRPS were identified thr

Monoclinic β-Ga2O3 films grown on c-plane sapphire have been shown to exhibit six (2¯01)-oriented domains, which are equally spaced by rotation around the surface normal and equally sized by volume that render the film optical response effectively uniaxial. We derive and discuss an optical model suitable for ellipsometry data analysis of such films. We model mid- and far-infrared ellipsometry data

The European spruce bark beetle is a major disturbance agent in Norway spruce forests in Europe, and with a changing climate it is predicted that damage will increase. To prevent the bark beetle population buildup, and to limit further spread during outbreaks, it is crucial to detect attacked trees early. In this study, we utilize Sentinel-2 data in combination with a risk map, created from geodat

Introduction: The scapular osseous free flap (SOFF) is being increasingly used for complex head and neck reconstructions. This study examined the surgical outcomes, focusing on post-operative complications and sequelae in patients who underwent SOFF for maxillary and mandibular reconstructions. Material and Methods: This retrospective, observational, population-based study included patients who un

In this study, wireless embedded relative humidity, RH, probes, developed by Electrotech Kalix AB, were evaluated in a laboratory setting. These RH-probes are designed to monitor the drying of concrete at construction sites in a Swedish climate. Two concrete slabs, each with a thickness of 100 mm, were fabricated, using two different concrete mixes, with water-to-cement (w/c) ratios of 0.6 and 0.4

This paper discusses the role of different factors determining the linguistic competence of heritage speakers (HSs) based on examples from speakers who speak a Romance language (French, Italian, Portuguese, or Spanish) as heritage language (HL) and German as the environmental language. Since the relative amount of contact with the HL and the environmental language may vary during the acquisition p

BACKGROUND: Experimental research has shown the benefits of auditory white noise on cognitive performance in children with attention problems. However, little is currently known about individual differences in noise response amongst children with a clinical diagnosis of attention deficit hyperactivity disorder (ADHD). In addition, no research has so far tested the effects of visual white noise on

In this paper, we argue that e-participation research is at a crossroads as its theories and empirical scope are increasingly detached from the contemporary relationship between information technology and political participation. We illustrate this challenge through two developments: (1) the dissolving boundaries between online and offline spheres of political participation and (2) the growing disIn this paper, we argue that e-participation research is at a crossroads as its theories and empirical scope are increasingly detached from the contemporary relationship between information technology and political participation. We illustrate this challenge through two developments: (1) the dissolving boundaries between online and offline spheres of political participation and (2) the growing dis