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The immunogenicity of biological therapeutic products is currently a high profile regulatory and biotechnology industry issue. The immune responses raised against biotechnology products range from the benign, to affecting product efficacy, to those that have serious deleterious clinical impact. The most widely used marker of immunogenicity is the detection and measurement of antibody responses ind
The advent of effective agents for the treatment of osteoporosis has led to the view that placebo-controlled trials to test new agents for efficacy are no longer appropriate since proven treatments are available. In this review we argue that, if new agents are to be developed, there is still a place for the placebo-controlled trial. A move to studies of equivalence or non-inferiority raises more p
The outcome after nerve repair in adults is generally poor. We hypothesized that forearm deafferentation would enhance the sensory outcome by increasing the cortical hand representation. A prospective, randomized, double-blind study was designed to investigate the effects of cutaneous forearm anaesthesia combined with sensory re-education on the outcome after ulnar or median nerve repair. During a
Background Quadricuspid aortic valve is a rare congenital heart defect. Several different anatomical variations of a quadricuspid aortic valve has been described and aortic regurgitation is the predominant valvular dysfunction associated with quadricuspid aortic valve. Case presentation A 68-year-old woman presented with almost a years history of increasing dyspnoea on exertion. The patient have
We previously reported that soluble decay-accelerating factor (DAF) and coxsackievirus-adenovirus receptor (CAR) blocked coxsackievirus 133 (CVB3) myocarditis in mice, but only soluble CAR blocked CVB3-mediated pancreatitis. Here, we report that the in vitro mechanisms of viral inhibition by these soluble receptors also differ. Soluble DAF inhibited virus infection through the formation of reversi
A sensor for monitoring the yield of tubers was tested in the laboratory and in the field. The laboratory test was designed to investigate whether the sensor varied in its measurements of tuber size, whether the recorded size differed within the width of the sensor, and whether tilting of the sensor affected the result. The test objects were spheres, and measurements were carried out on three diff
Laschiatrion (1), a new antifungal antibiotic, was isolated from fermentations of Favolaschia sp. 87129. (1) exhibits broad in vitro activity against several human pathogens while no antibacterial and cytotoxic activities could be detected. The structure was elucidated by spectroscopic techniques. As to our knowledge laschiatrion possesses a new steroid skeleton.
The burden of caregivers of patients suffering from of Alzheimer type dementia (DAT) and vascular dementia (VD) was analysed at the critical time, the “breaking-point”, when home care becomes insufficient and/or inadequate and the caregiver burden has probably reached its upper limit. Primary family caregivers of 39 DAT and 40 VD patients who were being considered for relocation into group-living
Objectives. To investigate whether any variables in a health-screened population study were associated with later developnent of large abdominal aortic aneurysms (AAA). Setting. Malmo, Southern Sweden. Material and methods. Within the Malmo Preventive Study 22,444 men and 10,982 women were investigated between 1974 and 1991. The mean age at the health screening was 43.7 years. Results. After a med
Here, we review the use of actin-based motors, (myosins; e.g., the molecular motor of muscle) in. nanotechnology. The review starts from the viewpoints of the molecular motors as being important devices responsible of cargo transportation in the cell and end in discussions about their employment in nanotechnological applications. First, we describe basic biophysics of the myosin motors with focus
Hip fracture is the most serious and resource consuming consequence of osteoporosis. All patients need operation and hospital treatment which gives a great health economic impact. The two main types of hip fracture are cervical (femoral neck, intracapsular) and trochanteric (extra capsular). For the displaced cervical fractures the blood circulation to the femoral head is more or less damaged whic
The aim of the present study was to develop a method for generation of dimethylbenzylamine (DMBA) atmospheres in an exposure chamber and to investigate the possibility of using urinary DMBA metabolites for biological monitoring of exposure to DMBA. A DMBA atmosphere was generated by use of the gas-permeation principle. Six healthy male volunteers were exposed for 8 h to DMBA at air levels of 20, 4
Popular Abstract in Swedish Denna doktorsavhandling i ämnet pedagogik utgör en analys av effekter av den pågående kulturella globaliseringen genom att granska två internationella magisterprogram vid Lunds universitet. Studiens syfte är att spåra mönster i en bärande pedagogisk idé för överföring av ett interkulturellt tänkande i tvärkulturella möten genom att utforska, beskriva och försöka förstå The present study is designed to analyze the effects of the ongoing cultural globalization. It utilizes as its empirical setting two special programmes called the International Master's Programme (the IMP,) directed by Lund University in Sweden. The aim of the study is to infer a pedagogic idea for intercultural transmission through cross-cultural encounters by exploring, describing, and comprehen
For the purpose of this deactivation study, Pt- and vanadia supported catalysts were used. The catalysts have been exposed to aerosol particles of inorganic salts, with high- or low melting points. The average diameter of the generated salt particle was kept constant at around 70 nm. The aerosol particle penetration depth for the samples exposed to potassium salt, was 1 μm as measured by scanning
Infection with Vibrio cholerae is a significant problem in manydeveloping countries. Cultivation of Vibrio cholerae is used inproduction of CTB, which is a component in a cholera vaccine. Fed - batch cultivations with V. cholerae in defined mediahave been conducted and reproducible results were obtained. A probing feeding strategy developed by Åkessonfor E. coli cultivations has been tested.The pr
Objective-The neuropeptide substance P (SP) is an inducer of neurogenic inflammation and bone resorption in the middle ear. Resorption of the bone tissue structures surrounding the middle ear cavity is a distinct feature of the initial stage of acute otitis media (AOM), which may be due to nerve fiber release of SP. Material and Methods-To investigate possible release of SP in the middle ear mucos
