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How pseudouridylation (Ψ), the most common and evolutionarily conserved modification of rRNA, regulates ribosome activity is poorly understood. Medically, Ψ is important because the rRNA Ψ synthase, DKC1, is mutated in X-linked dyskeratosis congenita (X-DC) and Hoyeraal-Hreidarsson (HH) syndrome. Here, we characterize ribosomes isolated from a yeast strain in which Cbf5p, the yeast homolog of DKC1
Mutations in DKC1, encoding for dyskerin, a pseudouridine synthase that modifies rRNA and regulates telomerase activity, are associated with ribosomal dysfunction and increased cancer susceptibility in the human syndrome, X-linked dyskeratosis congenita (X-DC). In a mouse model for X-DC, impairments in DKC1 function affected the translation of specific mRNAs harboring internal ribosomal entry site
Defects in ribosome biogenesis and function are present in a growing list of human syndromes associated with cancer susceptibility. One example is X-linked dyskeratosis congenita (X-DC) in which the DKC1 gene, encoding for an enzyme that modifies ribosomal RNA, is found to be mutated. How ribosome dysfunction leads to cancer remains poorly understood. A critical cellular response that counteracts
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia (CML), but the frequency of resistance increases in advancing stages of disease. Elimination of BCR/ABL-dependent intracellular signals triggers apoptosis, but it is unclear whether this activates additional cell survival and/or death pathways
The aim is to explore experiences and considerations of social workers regarding irregular migrants, understood as being prone to be “collateral damage.” It is revealed that some social workers approve assistance exceeding that which can find support in the national legislation. They are hereby addressing the normative conditions for recognition and installing new frames for apprehending irregular
The literature reveals an importance of social work in relation to all phases of crisis and disaster (Desai, 2007; IASSW 2010) and a potential to strengthen its role further (UNISDR 2015; Dominelli, 2012). Yet, little is known as regards the Swedish context. Given the centrality of municipalities in the emergency system and Social Services as a central municipal assignment it could be expected to
Traditionally, design analysts are solely responsible for all computerbased design analysis (CBDA). CBDA refers to quantitative design analyses utilising computational tools in the engineering design and development of technical solutions. There are currently limited insights into and knowledge of tools and methods needed to facilitate the use of CBDA by engineering designers. In order to gather i
In their quest for a more efficient and effective utilization of the resources allocated to engineering design projects, and thus to the overall product development project from which the current design task(s) originate, an increasing number of companies allow engineering designers to perform Computer-Based Design Analysis (CBDA) on their own – CBDA is here confined to quantitative analyses using
Växter behöver ljus. Ljuset omvandlas genom fotosyntesen till kemisk energi som kan lagras i växten. Mer ljus ger således mer energi men bara upp till en viss gräns. När växten inte längre kan hantera mängden ljus som den utsätts för kommer flaskhalsar i processen orsaka att högenergetiska tillstånd blir mer långlivade. Dessa reaktiva ämnen kan då orsaka skada på närliggande komponenter, vilket kaPlants and algae need light to drive the photosynthetic machinery. An excess of light will, however, result in damage to the photosynthetic machinery and to the rest of the organism. The surplus of energy, when exposed to light stress is converted into less harmful heat energy through a process called non-photochemical quenching. This quenching is partly dependent on the xanthophyll pool located i
Försörjningen är avgörande för kvinnors möjligheter att lämna en våldsam partner, och många hänvisas då till de offentliga försörjningssystemen. Syftet i artikeln är att förstå socialtjänstens handläggning av dessa kvinnor. Studien har ett medborgarskapsperspektiv där kvinnornas beskrivningar analyseras. Detta är en av de första svenska studierna på området.
Huntington's disease (HD) is a severe, genetic brain disorder that causes great suffering and leads to an early death. The medical research team in the project Treatments of the Future at Lund University aims to develop a new molecular gene therapeutic method that will give the possibility to cure the disease. The authors’, social- and cultural scientists, mission is to develop recommendations for
