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Laminins are heterotrimeric glycoproteins of the basement membranes. Laminin 1 (alpha 1, beta 1, gamma 1) is the major laminin expressed during early mouse embryogenesis. To gain access, to the physiological function of laminin alpha 1 chain, we developed a conditionally null allele of its encoding gene (Lama1) using the cre/loxP system. Floxed-allele-carrying mice (Lama1(flox/flox)) display no ov
When a child is diagnosed with diabetes, the symptoms may be in its most severe form with ketoacidosis, to mild symptoms of diabetes, detected incidentally. Moderate and severe symptoms of diabetes presentation require infusion therapy and thereby necessitate hospitalisation for the first few days. The initial management is largely a preparation for family members to help them gain the practical u
AIMS/HYPOTHESIS: We investigated the impact of type 1 diabetes on educational achievements in compulsory and upper secondary school, as well as potential long-lasting effects. METHODS: Altogether 2,485 individuals with type 1 diabetes, diagnosed at the age of <15 years and born in 1972-1978, were selected from the Swedish Childhood Diabetes Register, which was linked to national population registe
We demonstrate self-compression of 173 fs pulses centered at 1030 nm down to 19.5 fs through electro-optic phase modulation by the phonon-polariton waves generated in a phase-matched intra-pulse difference-frequency mixing.
In this paper, we present an extension of MadGraph5_aMC@NLO which is able to evaluate tree-level QCD matrix-elements up to 2 → 6 (one more particle than before). To achieve this, we implemented Berends–Giele-like recursion, and re-implemented the way colour is computed such that we can now expand the colour matrix in powers of 1 / Nc and truncate this expansion to a chosen order. For high multipli
Metabolic rewiring is a key feature of cancer cells to support the demands of growth and proliferation. The metabolism of amino acids is altered in many cancers, including pancreatic cancer. The cellular uptake of amino acids is regulated by amino acid transporters, such as L-type amino acid transporter 1 (LAT1). Accumulating evidence suggests that LAT1 is overexpressed in pancreatic cancer and co
Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de
Lymphocytes from human peripheral blood have been separated by countercurrent distribution in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000 with a cell yield of 59–88% and viability above 90%. A highly reproducible partition pattern was seen with four distinct peaks. Lymphocytes with surface membrane immunoglobulin (SmIg) were located in the first part o
Redovisning av miljöledningsarbetet 2023 2024-02-15 1 Redovisning av miljöledningsarbetet 2023 Enligt förordning (2009:907) om miljöledning i statliga myndigheter Lunds universitet Del 1. Miljöledningssystemet Basfakta Antal årsarbetskrafter: 7 482 åa Antal kvadratmeter: 437 694 m² Miljöcertifiering, miljöpolicy och miljöutredning 1. Är myndigheten miljöcertifierad? Nej 2. Hur lyder myndighetens m
Purpose: Multidisciplinary team meetings (MDTMs) are an integral component of cancer care. Increasingly, virtual MDTMs are used to grant high-quality treatment recommendations across health-care regions, which expands and develops the local MDTM team to a regional or national expert network. We investigated health professionals’ experiences from national, virtual MDTMs for rare cancer with a focus
Popular Abstract in Swedish Denna avhandling handlar om modeller för plana solfångare, transparent isolering och verkningsgradsfaktorer. En ekvation för energiutbytet från en glasad plan solfångare härleds genom att modellera verkningsgradsfaktorn, F´, som en summa av en konstant och en temperaturberoende del. Ett alternativt sätt att testa en plan solfångare, baserat på denna modell, föreslås. EThis thesis deals with models of flat plate collectors, transparent insulation and efficiency factors. An equation for the energy output from a glazed flat plate collector is derived by modelling the collector efficiency factor, F´ as the sum of a constant and a temperature dependent part. An alternative way of testing a flat plate collector, based on this model, is suggested. A complete set of a
