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To date, the use of CRISPR/Cas9 technology in ecological-model species for validating genotype to phenotype connections has focused primarily on visual phenotypes using G0 mutations, coupled with analyses of resulting mosaic phenotypes. However, studies of physiological phenotypes necessitate germline mutations in order to assess non-visible phenotypic effects, and thus, dedicated efforts to devel

Hur många roller ska skogen ta sig an? Skogen kan ta an många olika roller. Den kan vara en vacker vandringsmiljö. Kanske ett förvaringsutrymme för koldioxid? Eller till och med en viktig källa för bioenergi. Skogens förmåga att bidra med flera funktioner är fantastiskt men precis som andra naturresurser är förrådet begränsad. Dessutom är skogen en central del i klimatarbetet där dess funktion soThe land use, land-use change, and forestry sector (LULUCF) has historically been rather unregulated. Recent political developments have put pressure on countries to implement practices that increase net greenhouse gas (GHG) removals and improve the state of carbon sinks. One of these political developments is the European Union’s (EU) LULUCF Regulation, which as of now obligates Member States (MS

Popular Abstract in Swedish Hållbara matvanor - från jord till bord I Sverige äter vi i genomsnitt 800 kg mat per person och år. Vad och hur mycket vi väljer att stoppar i oss har stor betydelse både för planetens och vårt eget välmående. Den här avhandlingen handlar om hur våra val av livsmedel i den dagliga kosten påverkar miljön och hälsan. Vilken typ av livsmedel vi väljer att äta och dessa

Alfonso Pecha (b. 1327, d. 1389), Bishop of Spanish Jaén from 1359 to 1368, went to Italy after his resignation. There he made St. Bridget’s acquaintance. Alfonso who was a man of great learning and wide experience became St. Bridget's trusted advisor and assisted her in propagating her great causes (the return of the papacy from Avignon to Rome, a reform of the Church, the founding of a new order

IKEA is a product developing company, known for putting packaging and logistics issues at the top of its agenda. At IKEA, the product and the packaging are developed concurrently with the aim of lowering the total cost from the supplier to the customer. During the years 2002 to 2004, a pckaging redesign project was conducted at IKEA. The purpose of the project was to redesign the packaging for an

Introduction: Atypical hemolytic uremic syndrome (aHUS) is a progressive and potentially life-threatening disease characterized by complement-mediated thrombotic microangiopathy. Patients with aHUS may experience fatigue, which can negatively impact their lives, but there is a knowledge gap regarding disease burden in these patients. Methods: In this longitudinal study, patients with aHUS from the

Study design: Cross-sectional and longitudinal. Objectives: To (i) describe health-related quality of life (HRQoL) and changes over 6 years in older adults aging with long-term spinal cord injury (SCI) and (ii) investigate how changes in HRQoL are associated with age, gender, and injury characteristics. Setting: Community in southern Sweden. Methods: From the initial 123 participants (years 2011–2

Objectives: To determine meniscal extrusion and cartilage coverage on magnetic resonance (MR) images and factors associated with these parameters in knees of middle-aged and elderly persons free from radiographic tibiofemoral osteoarthritis (OA). Methods: Seven hundred eighteen persons, free of radiographic tibiofemoral OA, aged 50–90 years from Framingham, MA, USA, were included. We measured meni

BACKGROUND: The act of swallowing after gastric pull-up esophagectomy has not been thoroughly investigated. The aim of this study was to evaluate deglutition in the esophageal remnant and in the gastric conduit in patients who have undergone this operation.METHODS: The residual radionuclide activity was measured 15 seconds after a swallow in the esophageal remnant and at intervals up to a maximum

BACKGROUND: Larotrectinib is a first-in-class, highly selective tropomyosin receptor kinase (TRK) inhibitor approved to treat adult and pediatric patients with TRK fusion-positive cancer. The aim of this study was to evaluate the efficacy and safety of larotrectinib in patients with TRK fusion-positive primary central nervous system (CNS) tumors.METHODS: Patients with TRK fusion-positive primary C

Introduction: Treatment of Graves´ disease (GD) with radioiodine increases the risk of developing Graves´ ophthalmopathy (GO), and the link between thyroid and orbital tissue may be the presence of TSH-receptors. Radioiodine increases the titers of TRAb and the aim was to investigate the relationship between GO and TRAb titers after treatment with radioiodine and to define the impact of risk genes

Diffuse ultrasonic wave measurements used in structural health monitoring applications can detect damage in concrete. However, the accuracy is very susceptible to environmental variations. In this study, a large concrete floor slab was monitored using diffuse wave fields that were generated by continuous-wave transmissions between ultrasonic transducers. The slab was monitored for several weeks wh

The present review covers a wide scope of occupational heat stress related issues. The problematics related to climate change have placed heat exposure on the agenda. As a result, the research on heat effects has increased in recent years and a considerable amount of new material has become available. The literature includes general and specific reviews that focus on various heat-related aspects i

The effect of mineral fertilization and its application pattern on microbial activity and the subsequent CO2 and CH4 emissions arising from soil organic matter (SOM) or added substrate remains unclear. We quantified the decomposition of 13C-labeled straw and the priming effect (PE) governed by the N and P fertilizer application pattern during a 100-day experiment in a flooded soil. Straw addition

The research presented in this work represents reflections in the light of Julia Kristeva's philosophy concerning empirical data drawn from research describing the everyday life of people dependent on ventilators. It also presents a qualitative and narrative methodological approach from a person-centred perspective. Most research on home ventilator treatment is biomedical. There are a few publishe

PURPOSE: To describe clinical, optical coherence tomography (OCT) and fundus autofluorescence (FAF) findings in patients with intraocular tumors and determine if OCT and FAF could be helpful in the differential diagnosis and management of different choroidal tumors.METHODS: Forty-nine patients with untreated, macular, midperipheral, and extrapapillary intraocular tumors were included. All patients

OBJECTIVE: The aim of this study was to describe the clinical characteristics of early onset prostate cancer, with special reference to family history as a possible prognostic factor.MATERIAL AND METHODS: We identified all cases of prostate cancer diagnosed before the age of 51 in the Southern health care region in Sweden between 1958 and 1994. Clinical data were collected retrospectively from med

INTRODUCTION: Cytotechnologists have long been central to cervical cancer screening, although their education and job responsibilities differ markedly across countries. The adoption of primary HPV testing has substantially reshaped cytotechnology workforce needs and professional roles. In Sweden, however, no comprehensive overview of these changes exists. This study therefore examined cytotechnolo