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Sequence Correlations in HP Model Proteins

Amino acids that are in close contact in a protein structure tend to co-evolve, which gives rise to sequence correlations. Direct coupling analysis (DCA) is a method for predicting such contacts directly from sequence correlations, without assuming any prior knowledge of structures. To this end, sequence correlations are modeled using an Ising-like ansatz, whose couplings are determined through an

Atmospheric soot particle transformation from urban to rural

The main objective of this work was to investigate if there is a contribution of aerosol from the urban region of Copenhagen at the rural station Vavihill. This was done by analyzing measurement data between 1st of January and the 28th of February 2013 measured with a Dierential Mobility Particle Sizer (DMPS), Soot Particle Aerosol Mass Spectrometer (SP-AMS), a Cloud Condensation Nuclei Counter (C

Justice in their backyard : an analysis of rural energy transition and opposition to wind energy in Germany

The large-scale expansion of wind energy is an important element of the energy transition in Germany and a necessary tool to mitigate climate change. Yet, it is contested in many rural settings across the country. This thesis builds on the argument that rural areas are a crucial factor for the energy transition. They serve as the sites that host most of the infrastructure needed in the transition

Tvåundantaget i LAS och dess relation till kollektivavtal

In Sweden the first exception concerning turn rules was accepted in 1994 with the purpose to maintain the balance between employment protection and the companies need for flexibility. Since 2001 the exception concerning turn rules is limited to two employees for organisations with at most ten employees. In the year of 2020 the exception within the turn rules is up for discussion once again hence t

The Slippery Slope of Oil - Estimating the future GDP of Nigeria with uni- and multivariate approaches

Nigeria is, by population, the largest country in Africa and their economic growth will be a key part in the world reaching the goals of eradicating poverty. This paper investigates the economic growth performance of Nigeria and the relationship between oil and the GDP performance by using growth accounting, ARIMA, VAR and VEC models. Through the ARIMA and VAR models, the GDP is forecasted until 2

Undersökning av sensoriska bearbetningsmönster och dess koppling till sociodemografiska faktorer hos personer med psykisk ohälsa.

Bakgrund: Personer med psykisk ohälsa har ofta en nedsatt förmåga att bearbeta sinnesintryck. Tidigare har kopplingen mellan det individuella sättet att hantera sinnesintryck och olika sociodemografiska faktorer undersökts hos psykiskt friska personer, men studier gällande detta saknas för personer med psykisk ohälsa. Syfte: Att undersöka sensoriska bearbetningsmönster och deras eventuella kopplBackground: People with mental illness often have a reduced ability to process sensory inputs. Previously, the link between the individual way of dealing with sensory inputs and sociodemographic factors has been investigated in mentally healthy people, but there’s a lack of similar studies for people with mental illness. Aim: To investigate sensory processing patterns and their possible connecti

Skelettjordskonstruktioner - En undersökning av dess funktion med hydraulisk modellering i MIKE URBAN+

Urbanisering med växande och tätare städer i kombination med klimatförändring som förväntas kunna ge extremare väder kräver ett smart markanvändande där flera funktioner kan uppfyllas på samma yta. Ett exempel på en multifunktionell anläggning är skelettjordskonstruktioner som har en bärförmåga som hanterar ovanliggande laster, skapar gynnsamma förhållanden för träd och hanterar dagvatten med reniUrbanization with growing and denser cities in combination with climate change that is expected to produce more extreme weather requires a smart land use where several functions can be fulfilled on the same surface. An example of a multifunctional facility is structural soil that have a bearing capacity to handle loads, create favorable conditions for trees and handle stormwater with purification

Förekommer det skillnader mellan juristers och gemene mans moraliska ståndpunkter?

Syftet med studien var att undersöka om juristers moraliska uppfattning skiljer sig från gemene mans moraliska uppfattning. Den teoretiska bakgrunden om moral utgick från Haidts “Moral Foundations theory”, i enlighet med denna teori utgick studien från att det finns fem olika moraliska principer som utgör den moraliska kompassen. Centralt för studiens teoretiska bakgrund om beslutsfattande och inlThe purpose of the study was to explore whether or not there are any differences between attorneys and the average citizen's moral notions. The theoretical background mainly focused on Haidt’s Moral foundations theory, in accordance with this theory the study adhered to the five moral foundations that constitute the moral compass. A main part of the theoretical background was also the theory o

Dissolution kinetics and solubility of alpha synuclein in vitro

Amyloida fibriller är aggregat av självassocierande proteiner som tillsammans skapar ett tätpackat inre med hög ordningsgrad. Dessa fibriller är ofta förknippade med neurodegenerativa sjukdomar, t.ex. Alzheimers- och Parkinsons sjukdom. I dagsläget saknas botemedel för dessa sjukdomar och därav finns det intresse för att studera amyloida fibriller. Grundläggande forskning om exempelvis fibrillernaAmyloid fibrils are aggregates of self-assembled peptides and proteins that forms a highly ordered and densely packed core of β-strands stacking perpendicular to the length of the fibril. Amyloid fibrils of the protein α-synuclein (α-syn) are associated with Parkinson’s disease. This study aims at contributing to the physiochemical basis of α-synuclein aggregation and dissolution, mainly in terms

Phosphorous Precipitation in Source Separated Greywater for Direct Environmental Release.

Allt eftersom vår förståelse om vår egen miljöpåverkan förändras, så förändras också begräns- ningsstrategierna vi använder för att förhindra och motverka dem. En viktig källa till antropo- gena utsläpp är avloppsvatten eftersom det innehåller patogener, näringsämnen, och mikroför- oreningar. Ett skifte mot källsorterat avloppsvatten under de senaste åren har öppnat dörren för att anpassa och fokuAs our understanding of the impact humans have on the environment changes, so too do the mitigation strategies we employ to prevent it. One major source of anthropogenic pollution is wastewater effluent. A shift towards source separation of wastewater into different streams in recent years has opened a door to tailor treatment to specific types of water. The largest propor- tion of domestic wastew

Climate Displacement and Non-Refoulement: Opportunities and Challenges under Human Rights Law

Denna uppsats undersöker räckvidden av tillämpningsområdet av principen non-refoulement för personer som tvingas migrera på grund av klimatförändringar, genom rättighetskatalogerna ICCPR och EKMR. Ämnet är av stor betydelse eftersom effekterna av klimatförändringarna är beräknade att innebära en tvångsförflyttning av över en miljard människor innan år 2050. Frågan gällande vad dessa personer har fThis thesis examines the scope of non-refoulement under the international human rights instruments ICCPR and ECHR, in cases of climate displacement. This topic is important, as the effects of climate change are predicted to trigger a mass population displacement of over one billion people by the year 2050. This raises the issue of international protection for climate displaced persons, which will

Evaluating the Clinical Rank Model for Detection of Rare Variants from Whole Genome Sequencing

Utvärdering av Variantrankmodellen vid Genetiska Sjukdomar Vid misstänkt genetisk sjukdom kan en person få remiss till helgenomsekvensering, vilket är en teknik där näst intill hela DNA-uppsättningen (genomet) hos patienten blir avläst. Detta kan användas till att hitta skillnader, eller varianter, mellan patientens genom och ett friskt genom. Alla människor har väldigt många små ofarliga genetisIn this master’s thesis, different options to update the variant rank model used at the University hospital in Lund are presented. The variant rank model filters genetic variants from whole genome sequencing. This is done to identify potential causative variants in patients. Since the knowledge concerning these variants and rare genetic diseases grows rapidly, the model which filters said variants

The Swedish ankle arthroplasty register - An analysis of 531 arthroplasties between 1993 and 2005

Background Whether or not ankles can be replaced with reasonable safety has been the subject of debate. We present the results of a nationwide series of total ankle arthroplasties. Patients and methods All Swedish hospitals that implant or have implanted modern three-component ankle prostheses reported demographic data and date of index and revision surgery to a central register. After the data ha