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Background: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The firs

Small synthetic ligands for protein purification have become increasingly interesting with the growing need for cheap chromatographic materials for protein purification and especially for the purification of monoclonal antibodies (mAbs). Today, Protein A-based chromatographic resins are the most commonly used capture step in mAb down stream processing; however, the use of Protein A chromatography

Complement C2 deficiency (C2D) is associated with immunological diseases and increased susceptibility to invasive infections caused by encapsulated bacteria such as Neisseria menigitidis. In this study we evaluate the immunogenicity of vaccination against N. menigitidis in C2D. C2D patients (n=22) and controls (n=52) were given a tetravalent meningococcal polysaccharide vaccine. Serum bactericidal

Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac

BESLUT 20 I 0-02-18 Dor FIFO 2010/4 LUNDS UNIVERSITET Rektor Biträdande koordinatorer för strategiska forskningsområden Bakgrund Biträdande koordinatorer bör utses fOr de tolv strategiska forskningsområdena vid universitete!. Detta för att säkra långsiktigheten och bidra till en jämnare könsfördelning. Det är angeläget at! de biträdande koordinatorerna kan delta från starten av det universitetsöve

https://www.epihealth.lu.se/sites/epihealth.lu.se/files/bitradande_koordinatorer_feb10.pdf - 2026-07-02

Objective. Antileukoproteinase (ALP) is a physiologic inhibitor of granulocytic serine proteases. The present study was undertaken to investigate its therapeutic benefit in an antibody-transfer model of erosive polyarthritis and to elucidate its potential to interfere with immune complex-dependent inflammatory pathways. Methods. Arthritis development was induced in male (BALB/c x B10.Q)F-1 mice by

Transplantation of allogeneic embryonic neural tissue is a potential treatment for patients with Parkinson's and Huntington's diseases. The supply of human donor tissue is limited, and alternatives such as the use of animal (e.g., porcine) donor tissue are currently being evaluated. Before porcine grafts can be used clinically, strategies to prevent neural xenograft rejection must be developed. Kn

IgA nephropathy (IgAN) and Henoch-Schönlein purpura (HSP) are diseases characterized by IgA deposits in the kidney and/or skin. Both may arise after upper respiratory tract infections, but the pathogenic mechanisms governing these diseases remain unclear. Patients with IgAN (n = 16) and HSP (n = 17) were included in this study aimed at examining whether IgA-binding M proteins of group A streptococ

Antimicrobial peptides (AMPs) are evolutionarily ancient molecules. They are essential innate immune response molecules that protect organisms from invading pathogens. Tissue factor pathway inhibitors (TFPI-1 and TFPI-2) C-terminal derived peptides exert host defense mechanisms against microbes. Studies showed that in human plasma, C-terminal TFPI-1 and -2 derived peptides mediate bacterial killin

It has previously been shown that sera from multiparous women have increased levels of anti-idiotypic antibodies specific for anti-HLA molecules. γ-Globulins prepared from these sera may be superior to commercial preparations of intravenous γ-globulin (IVIg) for inhibiting HLA alloimmunization. To test this, F(ab′)2 fragments prepared from either commercial IVIg or from the sera of men or multipar

Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,

https://www.ses.lu.se/en/sites/ses.lu.se.en/files/2021-03/Syllabus_SMMV18_eng_HT21.pdf - 2026-07-02

https://www.sol.lu.se/media/utbildning/dokument/kurser/LIVA09/20262/LIVA05_dk_4_LIVA09_litteraturlista_HT_26.pdf - 2026-06-29

Svenska, språklig inriktning 1–40 poäng Vårterminen 2026 Litteraturlista för SVEG26, Svensk språkhistoria, 5 hp Fastställd av styrelsen för sektion 1 vid Språk- och litteraturcentrum den 5 nov 2025. Obligatorisk kurslitteratur Bianchi, Marco (2016). Runstenen som socialt medium. Ingår i: Andersson, Daniel, Edlund, Lars-Erik, Haugen, Susanne & Westum, Asbjørg (red.). Studier i svensk språkhistoria

https://www.sol.lu.se/media/utbildning/dokument/kurser/SVEG26/20261/LITT_SVEG26_VT26_1.pdf - 2026-06-29

LUNARC was formed as a collaboration between groups in Theoretical Chemistry, Physical Chemistry 2, and Structural Mechanics in 1986. The founding members were later joined by Theoretical Physics and in 1996, LUNARC was transformed into a centre for scientific and technical computing at Lund University. Together with five other centres, LUNARC became a part of the Swedish National Infrastructure f

https://www.lunarc.lu.se/about/history - 2026-07-01