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Typical glaucomatous visual field defects are often contiguous areas of diminished differential light sensitivity presenting as clusters of abnormally depressed points in the visual field chart. We investigated the value of recognizing arcuate cluster patterns, corresponding to the anatomy of the normal retinal nerve fiber layer. Cluster sizes were quantified using cluster volume and surface area.

Mango (Mangifera indica L.) is a tropical fruit which is considered to be a source of dietary fiber (DF) and phenolic compounds (PCs). In this study, high DF mango-based fruit bars were developed from whole mango (peel and pulp). The bars were evaluated for their nutritional composition, the bioaccesibility of PCs during gastrointestinal digestion, and the PCs metabolites profile after in vitro co

Pharmacokinetic and pharmacodynamic properties of a novel recombinant follicle-stimulating hormone (rFSH) preparation (FE 999049), expressed by a human cell line (PER.C6), was compared with an rFSH preparation (follitropin α) expressed by a Chinese hamster ovary (CHO) cell line in healthy pituitary-suppressed women. Following single intravenous administration of 225 IU (Steelman-Pohley assay), the

Brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and platelet-derived growth factor (PDGF) exert trophic effects on striatal neurons in vitro, which raises the possibility that these growth factors might also counteract neuronal death provoked by various insults. We have found that BDNF and NT-3, but neither PDGF-AA nor -BB, added 24 h before the insult ameliorated hypoglycemic neu

Background: A significant subset of prostate cancer (PC) patients with a castration-resistant form of the disease (CRPC) show primary resistance to androgen receptor (AR)-targeting drugs developed against CRPC. As one explanation could be the expression of constitutively active androgen receptor splice variants (AR-Vs), our current objectives were to study AR-Vs and other AR aberrations to better

Background: Kidney transplantation is considered a superior treatment for end-stage renal disease compared with dialysis although little is known about the wider effects, especially on labor market outcomes. The objective is to estimate the treatment effect of kidney transplantation compared with dialysis on labor market outcomes, controlling for the nonrandom selection into treatment. Methods: Th

Background: Despite improvements in therapy regimens over the past decades, overall survival rates for pancreatic and periampullary cancer are poor. Specific cancer registries are set up in various nations to regional differences and to enable larger prospective trials. The aim of this study was to describe the Swedish register, including possibilities to improve diagnostic work-ups, treatment, an

The wide life expectancy gap between the old and new member states of the European Union is most strongly related to the high rate of premature mortality caused by cardiovascular diseases (CVDs). To learn more about the background of this gap, the relationship of socioeconomic status (SES) with CVD mortality, morbidity and the utilization of antihypertensive drugs was studied in Hungary, a Central

Objectives: To examine whether different vertical drop jump (VDJ) landing depth (small versus deep) andstance width (wide versus narrow) may alter movement biomechanics in female recreational athletes.The purpose was also to identify whether leg muscle strength is a predictive factor for knee controlduring a VDJ.Design: Cross-sectional.Setting: Biomechanics laboratory. Participants: Eighteen womenObjectivesTo examine whether different vertical drop jump (VDJ) landing depth (small versus deep) and stance width (wide versus narrow) may alter movement biomechanics in female recreational athletes. The purpose was also to identify whether leg muscle strength is a predictive factor for knee control during a VDJ.DesignCross-sectional.SettingBiomechanics laboratory. Participants: Eighteen women ag

BACKGROUND: Beans are rich and inexpensive sources of proteins and carbohydrates around the world, but particularly in developing countries. However, many legume varieties are still underutilized. In this study, physical characteristics of the seeds of three Phaseolus lunatus cultivars were characterized. Also, the chemical composition and starch digestibility in the cooked beans were assessed. RE

BACKGROUND: Tortillas were prepared from two (blue and regular white) maize varieties and compared with regard to chemical composition and in vitro starch digestibility, i.e., available starch (AS), total (RS) and retrograde (RRS) resistant starch contents, amylolysis rate and predicted glycemic index (pGI). The impact of cold storage (4°C) on digestibility was also investigated. RESULTS: Despite

To increase the added value of arracacha flour, a soup type food was designed considering the traditional culinary recipes of this root. The methodology applied for this purpose, allowed to obtain the baked flour, and also the characterization of the physicochemical, functional composition, and in vitro digestibility; as well as to propose some formulations varying the flour contents from 40 to 65

We present a non-resonant, dual band circular polarization selective structure (CPSS) for satellite communication applications in the K- and Ka-bands. The structure consists of multiple layers of cascaded anisotropic sheets, with printed meander lines, separated by low permittivity spacers. It reflects right handed circular polarization and transmits left handed circular polarization in the lower

Hydrogen is an element of fundamental importance for energy but hard to quantify in bulk materials. Neutron radiography was used to map . in situ loss of elemental hydrogen from beech tree wood samples during pyrolysis. The samples consisted of three wood cylinders (finished dowel or cut branch) of approximately 1 cm in length. The samples were pyrolyzed under vacuum in a furnace vessel that was p

Purpose: To report five novel genetic variants in seven unrelated consanguineous families with achromatopsia (ACHM). Methods: Patients were examined with multimodal retinal imaging and full-field electroretinography (ffERG). Genetic testing was conducted using next-generation sequencing (NGS). Results: Three novel homozygous variants were detected in CNGA3: a missense c.967G > C (p.Ala323Pro) vari