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Background: A study was designed to assess a computer-based program for continuous registration of antibiotic resistance, statistics concerning severity of illness, and consumption of antibacterial drugs. Methods: The frequency of antibiotic resistance among bacteria in eight ICUs in southeastern Sweden was investigated yearly from 1995 through 1997. The antibiotic consumption in the ICUs was regi
EU countries have committed to taking national measures to reduce the average energy use of residential buildings by 16% by 2030 and 20–22% by 2035. Each country has decided how to achieve this and which buildings to focus on. However, certain categories of residential buildings, including historical buildings but also second homes, may be exempt from these obligations. In Sweden, second homes con
Deep electrification powered by renewable sources has emerged as a pivotal strategy for achieving ambitious CO2 emission reduction targets. However, the true impact of electrification on decarbonization remains inadequately measured because the whole energy chain has not yet been fully considered. This study combines Societal Exergy Accounting and Logarithmic Mean Divisia decomposition analysis to
Background: The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune-checkpoint-based therapies still poses a significant problem. Objective: Here, we mine large-scale MM proteogenomic data to identify druggable targets and forecast treatment efficacy and resistance. Methods: Leveraging protein profiles from
Excessive worry is common during adolescence and across psychiatric disorders. This study investigates whether: 1) internet-delivered cognitive behavioral therapy (ICBT) focused on exposure to uncertainty is effective in reducing excessive worry; 2) improvements in worry are associated with reductions in other psychiatric symptoms; and 3) changes in intolerance of uncertainty (IU) mediates worry o
Wetlands play a critical role in the global water cycle and ecological health. However, understanding and accurately parameterizing water and heat exchanges in these areas is challenging due to the heterogeneous nature of wetland surfaces. This study extends the maximum entropy production (MEP) model to simulate wetland evapotranspiration (ET) by integrating NDVI dynamics, water evaporation, and p
This study systematically evaluates and meta-analyzes Mendelian randomization studies on the bidirectional causal relationship between Alzheimer’s disease (AD) and systemic diseases. We searched five databases, assessed study quality, and extracted data. Diseases were classified using ICD-11, and the meta-analysis was performed with RevMan 5.4. A total of 56 studies identified genetic links betwee
BACKGROUND: The aim of this study was to investigate possible associations between educational level, occupation, and hospitalization for inflammatory bowel disease.METHODS: A nationwide database was constructed by linking the Swedish Census to the Hospital Discharge Register in order to obtain data on all first hospitalizations for Crohn's disease (CD) and ulcerative colitis (UC) in Sweden during
OBJECTIVE: This study analyzed men and women separately by age at hospital diagnosis of psychotic disorder or schizophrenia and by maternal or paternal disease after taking several possible confounders into account.METHODS: The Multigeneration Register, in which all men and women born in Sweden from 1932 onwards are registered together with their parents, was linked to hospital data. This yielded
We used the nationwide Swedish Family-Cancer Database to analyze the risk for nervous system tumors in offspring through parental and sibling probands. Among 0-68-year-old offspring, close to 11000 patients with a nervous system tumor were identified in years 1961 to 2000, among whom 199 had a parent diagnosed with a nervous system tumor. Brain tumors constituted 86% of all tumors, and astrocytoma
We used the nationwide Swedish Family-Cancer Database to analyze the risk for soft tissue tumors in offspring by parental cancers and in siblings of soft tissue tumor probands. Additionally, risk for second cancer following soft tissue tumor was investigated. In offspring, 1488 soft tissue tumors were diagnosed between years 1958 and 1996. Groups of offspring were compared by calculating standardi
Characteristics of the built environment, including access to unhealthy food outlets, are hypothesized to contribute to type 2 diabetes mellitus (T2D). Swedish nationwide registry data on 4,718,583 adults aged 35-80 years living in 9,353 neighborhoods, each with at least 1 food outlet, were geocoded and linked to commercial registers (e.g., restaurants and grocery stores). Multilevel logistic regr
Introduction: To reduce local recurrence rates when performing anterior resection in rectal cancer surgery Swedish national guidelines recommend rectal washout. This study aimed to describe current Swedish practice of rectal washout. Methods: Questionnaires were sent to Swedish surgical departments performing rectal cancer surgery. Results: Thirty-five units performed open rectal cancer surgery, a
Boiling heat transfer intensification is of big relevance to energy conversion and conservation, materials and resources saving, and electronics cooling. This work aims to enhance saturated pool boiling of well-wetting liquids, i.e., acetone and HFE-7200 on nanoparticles-deposited surfaces by electrophoretic deposition and on microporous foam surfaces by electrochemical deposition. The electrophor
The current study aims to computationally evaluate the hemodynamic impact of a novel sealing mechanism employed by a recently developed endograft (Ovation TriVascular Stent-Graft System) for endovascular aneurysm repair. The exploitation of two inflatable O-rings to achieve sealing may be advantageous in terms of accommodating challenging anatomies, but comes at a price of a marked inflow stenosis
Background: Nerve growth factor (NGF) and brain-derived neural factor (BDNF) are important for brain function and detectable in the blood. This study explored the longitudinal associations of physical activity and body fat with serum NGF and BDNF in children. Methods: Two waves of measurements were performed 2 years apart in 8- to 11-year-old children, including physical activity using the ActiGra
Objectives: COPD is a common and disabling disease that entails high costs for society. The objectives of this study were to measure the societal costs of COPD in Sweden, and to examine the relationship between severity of illness and costs. Methods: The costs of COPD were examined using a well-defined and representative cohort of subjects with mild, moderate, and severe COPD. Regular telephone in
