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The annual number of hip fractures in Sweden will double from year 2002 to 2050.
Background and purpose - The incidence and annual number of hip fractures have increased worldwide during the past 50 years, and projections have indicated a further increase. During the last decade, however, a down-turn in the incidence of hip fracture has been seen in the western world. We predicted the development of hip fractures in Sweden until the year 2050. Methods - We reviewed surgical re
In-kind transfers of maize, commercialization and household consumption in Kenya
This article discusses in kind food transfers and whether such transfers should be interpreted as a sign of the failure of grain markets to meet the food demands of the poor. The paper elucidates on aspects of both consumption and in kind transfers of maize against a backdrop of poorly functioning markets. The paper adds to the theoretical understanding of household based linkages and provides a d
Racemic, S(+)- and R(-)-ketamine do not increase elevated intracranial pressure
Background: There is controversy regarding the influence of ketamine and its enantiomers on cerebral haemodynamics at increased intracranial pressure (ICP). This study was designed to compare cerebrovascular responses, with particular respect to ICP, to bolus injections of racemic, S(+)- and R(-)-ketamine in an experimental model of intracranial hypertension. Methods: Nine pigs were anaesthetised
First incidence depression in the Lundby Study: A comparison of the two time periods 1947-1972 and 1972-1997.
Background: The Lundby Study is a prospective, longitudinal study on a total population consisting of 3563 subjects during 50 years. This study compares first incidence rates of depression and cumulative probabilities for developing a depression over the two time periods 1947-1972 and 1972-1997. Method: The Lundby Study started in 1947. Follow-ups were carried out in 1957 and in 1972. In 1997 the
Equilibrium sampling through membranes (ESTM) of acidic organic pollutants using hollow fibre modules in continuous steady-state mode.
Hollow fibre (HF) membrane modules were applied in continuous mode for equilibrium sampling through membranes (ESTM) of polar organic pollutants. Phenolic compounds (chlorophenols, cresols and phenol) served as model substances and ESTM was tuned towards the measurement of freely dissolved concentrations (C(free)). HF membrane modules were constructed using thin-walled membrane, 1-m module length
Anti-arthritic effect of methotrexate: is it really mediated by adenosine?
The mechanism of action for the anti-arthritic effect of methotrexate (MTX) was investigated in rats with antigen-induced arthritis (AIA). Arthritis intensity was quantified as area under the curve (AUC) for the joint swelling. The response to MTX was in several respects similar to what is seen in the clinic. The drug reduced the AUC in a dose-dependent manner after oral weekly (2-4 mg/kg/week) or
Stand transpiration and sapflow density in relation to weather, soil moisture and stand characteristics
Sapflow density was measured in six stands in a boreal forest in central Sweden, to assess its dependence on soil moisture and stand characteristics. The stands were mixed and pure Scots pine and Norway spruce stands, which were between 34 and 105 years old. Sapflow was measured in 12 trees per stand using the Granier method during two contrasting growing seasons; one warm and dry and one wet and
Response of Norwegian Sea temperature to solar forcing since 1000 AD
Abstract: We report on a 1000 year long oxygen isotope record in sediments of the eastern Norwegian Sea which, we argue, represents the temperature and transport of warm Atlantic waters entering the Nordic Sea basin via the North Atlantic Drift and the large-scale Meridional Overturning Circulation. The single-sample resolution of the record is 2.5-10 years and age control is provided by Pb-210 an
Describing sorption of pharmaceuticals to lake and river sediments, and sewage sludge from UNESCO Biosphere Reserve Kristianstads Vattenrike by chromatographic asymmetry factors and recovery measurements
Environmental arsenic exposure and DNA methylation of the tumor suppressor gene p16 and the DNA repair gene MLH1: effect of arsenic metabolism and genotype.
Arsenic is carcinogenic, possibly partly through epigenetic mechanisms. We evaluated the effects of arsenic exposure and metabolism on DNA methylation. Arsenic exposure and methylation efficiency in 202 women in the Argentinean Andes were assessed from concentrations of arsenic metabolites in urine (inorganic arsenic, methylarsonic acid [MMA], and dimethylarsinic acid [DMA]), measured by HPLC-ICPM
Maternal Autoimmune Thyroid Disease and the Fetal Immune System.
OBJECTIVE: Several studies indicate that in utero exposure to maternal autoimmune diseases and transplacental passage of autoantibodies affect the risk of autoimmunity in the offspring, e. g., maternally derived GAD65 autoantibody correlates with decreased risk of type 1 diabetes, whereas thyroid peroxidase autoantibody (TPOAb) positivity at birth is associated with increased incidence of autoimmu
Segmented tetrasulfonated copoly(arylene ether sulfone)s: improving proton transport properties by extending the ionic sequence
The morphologies and proton-transport efficiencies of segmented copoly(arylene ether sulfone) ionomers that contain tetrasulfonated sequences are compared with the corresponding copolymers with disulfonated sequences. Tetrasulfonated 4,4′-bis[(4-chlorophenyl)sulfonyl]-1,1′-biphenyl (sBCPSBP) is synthesized by metalation and sulfination. This new monomer is then used in K2CO3-mediated polycondensat
Superior compliance with a neuromuscular training programme is associated with fewer ACL injuries and fewer acute knee injuries in female adolescent football players: secondary analysis of an RCT
Background Little is known about the influence of compliance with neuromuscular training (NMT) on the knee injury rate in football. Aim To evaluate team and player compliance with an NMT programme in adolescent female football and to study the association between compliance and acute knee injury rates. Methods Prospective cohort study based on a cluster randomised controlled trial on players aged
Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time
p53 is involved in stress response, metabolism and cardiovascular functioning. The C-allele of rs1042522 in the gene encoding for p53 is associated with longevity and cancer. In this study, we aimed to investigate the association of rs1042522 with changes in blood pressure, BMI and waist circumference using a longitudinal approach. Rs1042522 was analyzed in two longitudinal studies; the Doetinchem
Tensile Strength After Closure of Mesenteric Gaps in Laparoscopic Gastric Bypass: Three Techniques Tested in a Porcine Model.
BACKGROUND: Internal hernias occur frequently after laparoscopic gastric bypass. We have found no data on the relative strength of the various techniques available for closing these defects. The present study was performed to obtain such data to form a theoretical basis for clinical studies. METHODS: Six piglets were operated laparoscopically and four loops of small bowel created in each. These me
Completion axillary dissection can safely be omitted in screen detected breast cancer patients with micrometastases. A decade's experience from a single institution.
BACKGROUND: The need for completion axillary lymph node dissection (ALND) in breast cancer patients with micrometastases in the sentinel nodes (SNs) is controversial. The aim of this retrospective observational study is to determine if the method of detection of early breast cancer is predictive for additional positive nodes in patients with micrometastases in the SNs. METHODS: Between 2001 and 20
Multicriteria evaluation of discharge simulation in Dynamic Global Vegetation Models
In this study, we assessed the performance of discharge simulations by coupling the runoff from seven Dynamic Global Vegetation Models (DGVMs; LPJ, ORCHIDEE, Sheffield-DGVM, TRIFFID, LPJ-GUESS, CLM4CN, and OCN) to one river routing model for 16 large river basins. The results show that the seasonal cycle of river discharge is generally modeled well in the low and middle latitudes but not in the hi
Long-term temporal and spatial trends in eutrophication status of the Baltic Sea
Much of the Baltic Sea is currently classified as 'affected by eutrophication'. The causes for this are twofold. First, current levels of nutrient inputs (nitrogen and phosphorus) from human activities exceed the natural processing capacity with an accumulation of nutrients in the Baltic Sea over the last 50-100 years. Secondly, the Baltic Sea is naturally susceptible to nutrient enrichment due to
Hemorrhage after Major Pancreatic Resection: Incidence, Risk Factors, Management, and Outcome.
Hemorrhage is a rare but dreaded complication after pancreatic surgery. The aim of this study was to examine the incidence, risk factors, management, and outcome of postpancreatectomy hemorrhage in a tertiary care center. A retrospective observational study was conducted on 500 consecutive patients undergoing major pancreatic resections at our institution. Postpancrea-tectomy hemorrhage was define
