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Synergistic platelet inhibition between Omega-3 and acetylsalicylic acid dose titration; an observational study

Background: Omega-3 and acetylsalicylic acid (ASA) are two widely used “over-the-counter” drugs. Previous researchhas shown multiple electrode aggregometry (MEA) can detect ASA and varying Omega-3 platelet inhibiting effects.Synergistic platelet inhibiting effects of ASA and Omega-3 have been found using other methods than MEA. The aimof this study was to investigate the antiplatelet effects of Om

The Not so Simple Stellar System ω Cen. II. Evidence in Support of a Merging Scenario

We present multiband photometry covering ∼5° × 5° across ω Cen collected with the Dark Energy Camera on the 4 m Blanco telescope, combined with Hubble Space Telescope and Wide Field Imager data for the central regions. The unprecedented photometric accuracy and field coverage allows us to confirm the different spatial distribution of blue and red main-sequence stars, and of red giant branch (RGB)

Diagnosing deep vein thrombosis in cancer patients with suspected symptoms : An individual participant data meta-analysis

Background: A previous individual participant data (IPD) meta-analysis showed that the Wells rule and D-dimer testing cannot exclude suspected deep vein thrombosis (DVT) in cancer patients. Objectives: To explore reasons for this reduced diagnostic accuracy and to optimize the diagnostic pathway for cancer patients suspected of DVT. Patients and Methods: Using IPD from 13 studies in patients with

Manganese doped eco-friendly CuInSe2 colloidal quantum dots for boosting near-infrared photodetection performance

CuInSe2 (CISe) colloidal quantum dots (QDs) display promising applications in photodetection especially within near-infrared (NIR) regions due to their high extinction coefficient and environmental-friendly. However, the high trap density and poor crystal quality introduced by the ternary structure result in low photodetection of CISe QDs devices. Herein, we dope transition metal manganese ions (M

Development of early calcareous nannoplankton in the late Triassic (Northern Calcareous Alps, Austria)

Calcareous nannofossils are considered to be the most productive calcifying organisms, but the impact of their emergence on the chemistry of the ocean in the Late Triassic is not understood yet. Evolutionary details of this bio-event are missing due to the scarcity of well-preserved outcrops worldwide. The current study focuses on the calcareous nannofossil assemblage of the middle Norian to lower

Ageing and glaucoma progression of the retinal nerve fibre layer using spectral-domain optical coherence tomography analysis

Purpose: To compare the effects of ageing and glaucoma progression on the thickness of the circumpapillary retinal nerve fibre layer (cpRNFL) and to evaluate the performance of a set of optical coherence tomography (OCT) progression analyses. Methods: The cpRNFL was measured twice by OCT at each of two visits made 10 years apart in 69 healthy individuals and 49 glaucoma patients. Both visits also

Impact of beam angle choice on pencil beam scanning breath-hold protontherapy for lung lesions

Introduction:The breath-hold technique inter alia has been suggested to mitigate the detrimental effect of motion on pencil beam scanned (PBS) proton therapy dose distributions. The aim of this study was to evaluate the robustness of incident proton beam angles to day-to-day anatomical variations in breath-hold.Materials and methods: Single field PBS plans at five degrees increments in the transve

Biochar increases soil microbial biomass but has variable effects on microbial diversity : A meta-analysis

Biochar has been extensively studied as a soil amendment for carbon sequestration and for improving soil quality; however, a systematic understanding of the responses of soil microbial biomass and diversity to biochar addition is lacking. Here, a meta-analysis of 999 paired data points from 194 studies shows that biochar increases microbial biomass but has variable effects on microbial diversity.

Use of cardiovascular drugs and risk of incident heart failure in patients with atrial fibrillation

Congestive heart failure (CHF) is the most important cause of death in patients with atrial fibrillation (AF). We aimed to study the association between cardiovascular drugs in AF patients and incident CHF. The study population included all adults (n = 120 756) aged ≥45 years diagnosed with AF in Sweden diagnosed for the period 1998-2006. Outcome was incident congestive heart failure (follow-up 20

The SkyMapper-Gaia RVS view of the Gaia–Enceladus–Sausage – an investigation of the metallicity and mass of the Milky Way’s last major merger

We characterize the Gaia–Enceladus–Sausage kinematic structure recently discovered in the Galactic halo using photometric metallicities from the SkyMapper survey, and kinematics from Gaia radial velocities measurements. By examining the metallicity distribution functions (MDFs) of stars binned in kinematic/action spaces, we find that the JR‾‾‾√ versus Lz space allows for the cleanest selection of

The influence of dust growth on the observational properties of circumplanetary discs

Dust growth is often indirectly inferred observationally in star-forming environments,theoretically predicted to produce mm-sized particles in circumstellar discs, and also presumably witnessed by the predecessors of the terrestrial meteoritic record. For those reasons it is believed that young gas giants under formation in protoplanetary discs with putative circumplanetary discs (CPDs) surroundin

Antisecretory Factor May Reduce ICP in Severe TBI—A Case Series

Traumatic brain injury (TBI) constitutes a global epidemic. Overall outcome is poor, with mortality ranging from 10 to 70% and significant long-term morbidity. Several experimental reports have claimed effect on traumatic edema, but all clinical trials have failed. Antisecretory factor, an endogenous protein, is commercially available as Salovum®, which is classified as a medical food by the Europ

Tobacco use, body mass index and the risk of malignant lymphomas--a nationwide cohort study in Sweden

In the search for risk factors involved in the etiology of lymphoproliferative malignancies there is still inconsistent evidence regarding effects of smoking tobacco, and the role of smokeless tobacco is poorly investigated. New evidence indicates that excess body weight increases the risk of NHL and HD. To determine if tobacco use of various forms and high Body Mass Index (BMI) affect the occurre

Long-term co-administration of sodium nitrite and sodium hydrosulfide inhibits hepatic gluconeogenesis in male type 2 diabetic rats : Role of PI3K-Akt-eNOS pathway

Objective: A deficiency in hydrogen sulfide (H2S) and nitric oxide (NO) contributes to the development of type 2 diabetes (T2D). An inhibitory effect on liver gluconeogenesis has been reported in rats with T2D with co-administration of sodium nitrite and sodium hydrosulfide (NaSH); the underlying mechanisms have however not yet been elucidated. The aim of this study is to determine the long-term e

Regional inhaled deposited dose of indoor combustion-generated aerosols in jordanian urban homes

Indoor combustion processes associated with cooking, heating, and smoking are a major source of aerosols in Jordanian dwellings. To evaluate human exposure to combustion-generated aerosols in Jordanian indoor environments, regional inhaled deposited dose rates of indoor aerosols (10 nm to 25 µm) were determined for different scenarios for adult occupants. The inhaled deposited dose rate provides a