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Recombinant adeno-associated viral vectors display efficient tropism for transduction of the dopamine neurons of the substantia nigra. Taking advantage of this unique property of recombinant adeno-associated viral vectors, we expressed wildtype and A53T mutated human alpha-synuclein in the nigrostriatal dopamine neurons of adult rats for up to 6 months. Cellular and axonal pathology, including alp

The composition of the dominating population of freshly cut beef, and beef stored at 4 degrees C for 8 d, was studied by direct analysis of the 16S rRNA gene (PCR amplification, cloning and sequencing) and compared with pure culture technique where the isolates picked from the viable plate count were identified by sequencing of the 16S rRNA gene. The composition of the bacterial population was rec

The influence of pH on the relative importance of the two principal decomposer groups in soil, fungi and bacteria, was investigated along a continuous soil pH gradient at Hoosfield acid strip at Rothamsted Research in the United Kingdom. This experimental location provides a uniform pH gradient, ranging from pH 8.3 to 4.0, within 180 m in a silty loam soil on which barley has been continuously gro

Giant cell tumor of bone (GCTB) is a benign but locally aggressive tumor with metastatic potential. We performed cytogenetic analysis on 10 1 GCTB from 92 patients. Karyotypes were obtained from 95 tumors, 47 of which had clonal aberrations. The majority of the cytogenetically abnormal GCTB had multiple, up to 28 per tumor, clones. Clonal telomeric associations (tas) and other structural and numer

This study reports carbon and water fluxes between the land surface and atmosphere in eleven different ecosystems types in Sub-Saharan Africa, as measured using eddy covariance (EC) technology in the first two years of the CarboAfrica network operation. The ecosystems for which data were available ranged in mean annual rainfall from 320 mm (Sudan) to 1150 mm (Republic of Congo) and include a spect

The purpose of this study was to identify new prognostic biomarkers with clinical impact in malignant peripheral nerve sheath tumor (MPNST), a highly aggressive malignancy for which no consensus therapy exists besides surgery. We have used tissue microarrays (TMAs) to assess in situ expression of 14 cell-cycle-regulating proteins in 64 well-characterized MPNST patients: 36 sporadic and 28 with neu

Aims/hypothesis: Mutations in hepatic nuclear factor 1alpha cause a monogenic form of diabetes, maturity onset diabetes of the young type 3 (MODY3). Our aim was 1) to assess the uptake of genetic testing for MODY3 and to determine factors affecting it, and ( 2) to compare attitudes to predictive genetic testing between families with MODY3 and a previously studied group at risk of hereditary nonpol

Inflammatory challenges of the airway mucosa cause luminal entry of bulk plasma. Extravasation of plasma is well described but the routes for epithelial passage of plasma are largely unknown. Using colloidal gold (5 nm) as tracer we have now examined the fate of extravasated plasma in the airways. The tracer was given intravenously to anaesthetized, ovalbumin-sensitized guinea-pigs 2min prior to a

The aim of this study was to evaluate the role of thromboxane A2 in bradykinin-induced airflow obstruction in guinea pig in vivo. Airway insufflation pressure (Pi) was measured to assess airflow obstruction and the thromboxane B2 (a stable metabolite of thromboxane A2) concentration in bronchoalveolar lavage fluid was determined by radioimmunoassay. The animals were pretreated with propranolol (1

BACKGROUND: Increased levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been shown to reduce the hormones in the HPA axis. In this study we addressed the question whether patients with unmedicated major depressive disorder (MDD) might have altered baseline levels of these natriuretic peptides and an altered response to acute exercise. METHODS: An incremental exerc

Objective Zinc transporter 8 autoantibodies (ZnT8A) have been poorly studied in non-Caucasian individuals. We aimed to investigate the prevalence of ZnT8 autoantibodies in patients with T1D and their first degree relatives (FDR) from a multiethnic population, as well as its relation with the insulin (INS) or the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene polymorphisms. Subjects and

Purpose The purpose of this research is to explore the effects of format development of an original single-format general merchandise retailer on store image. Theoretical Perspectives This study is grounded on the alignment of existing literature in the fields of format development and store image. The theoretical framework build thereupon is bridging the two fields and develops a model to measur

TGFα is a member of the epidermal growth factor (EGF) family and is one of the ligands for the EGF- receptor. The precursor of TGFα, pro-TGFα, is a transmembrane protein. The aim of this project has been to establish a model for studies of pro-TGFα effects on EGF receptor signalling, in particular through Gab1, a docking protein involved in PI3K/Akt signalling pathway. The experiments in this thes

In this study the dangers of Listeria monocytogenes presence in food and the problem it creates for general food safety is presented. The aim of this study was to highlight the importance of food safety, especially when it concerns Listeria monocytogenes. The study should also give an insight to the part that Listeria monocytogenes plays among food and the risks that follows. Furthermore, it wil

In this thesis work, a highly linear passive attenuator and mixer were designed to be used in a wide-band Transmission Observation Receiver (TOR). The TOR is a low IF receiver that accepts RF frequencies from 2GHz to 7GHz, and produces corresponding IF bandwidths of 280MHz to 990MHz respectively, using low side LO injection. The dynamic range is maximized by using passive topologies for both the a

Syfte Syftet med denna uppsats är på kort sikt undersöka om det finns en optimal placeringshorisont för frimärksaktier efter deras IPO. Utifrån detta analyseras huruvida en investeringsstrategi kan skapas som genererar överavkastning i förhållande till OMXSPI. Metod Studien är en kvantitativ eventstudie som enbart använder sekundärdata. Studien använder ett antal olika statistiska och ekonometrPurpose The purpose for this thesis is to evaluate the short-term optimal holding period for penny stocks on the Swedish market after IPO. It analyzes if there can be an investment strategy formed that yields an abnormal return compared to the general index OMXSPI. Methodology This study is a quantitative event study that only utilizes secondary data. The paper uses several different statistica

Utveckling av mätteknik för mätning av rörligheten i knäleder hos barn med Cerebral pares Cerebral pares (CP) är en neurologisk störning som kan leda till förlust eller nedsättning av de motoriska funktioner som påverkar kroppens rörelser, muskelkontroll, koordination och balans. CP kan orsaka obalanser mellan musklerna som kan leda till kontrakturer. Kontrakturer innebär att musklerna förkortas Cerebral Palsy, commonly referred to as CP, is a neurological disorder that results in loss or impairment of motor function, which affects body movement, muscle control, muscle coordination and balance. In Sweden, about 200 children are diagnosed with Cerebral Palsy every year and the disorder can cause imbalances between the muscles. These imbalances can lead to contractures which is equiva- lent

Uppsatsens syfte var att undersöka om brottslagstiftningen, närmare bestämt uppsåtsrekvisitet, fängelsepresumtionen och bestämmelsen om rättspsykiatrisk vård, tillämpas enhetligt när det gäller psykiskt störda lagöverträdare? Efter att ha besvarat den frågan skulle svaret fungera som ett underlag för en diskussion om huruvida rättstillämpningen vid allvarlig psykisk störning är förutsebar ur ett rThe purpose of the essay was to investigate whether criminal law, in particular the necessary intentional prerequisite, the presumption of prison and the provision of forensic psychiatric care, is applied uniformly in the case of mentally disrupted offenders? After answering that question, the answer would serve as a basis for a discussion as to whether law enforcement in case of severe mental dis