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Arcanobacterium haemolyticum, clinical, diagnostic and therapeutic aspects
Popular Abstract in Swedish Arcanobacterium haemolyticum (A. haemolyticum) beskrevs för första gången under namnet Corynebacterim haemolyticum av MacLean och medarbetare 1946. Bakterien odlades fram från svalget hos patienter med halsont och från sår. Patienterna bestod av amerikanska soldater och infödda öbor i Stilla havet. Från olika delar av världen har senare beskrivits halsont och utslag hosIn an 18-month period all throat cultures in our laboratory were examined for Arcanobacterium haemolyticum and clinical information was obtained. The great majority of the patients suffered from pharyngitis or tonsillitis, accompanied by a rash in 46% of cases. One third of the patients had a history of recurrent tonsillitis. Three types of exanthema was described, scarlatiniform, urticarial and e
Water uptake by biomass burning aerosol at sub- and supersaturated conditions: closure studies and implications for the role of organics
We investigate the CCN activity of freshly emitted biomass burning particles and their hygroscopic growth at a relative humidity (RH) of 85%. The particles were produced in the Mainz combustion laboratory by controlled burning of various wood types. The water uptake at sub- and supersaturations is parameterized by the hygroscopicity parameter, κ (c.f. Petters and Kreidenweis, 2007). For the wood b
Improving thermal comfort in an orthopaedic aid: better boston brace for scoliosis patients
Scoliosis is an S-shaped sideways curvature of the spine leading to the shape change of the torso Idiopathic scoliosis is one form of this disease with unknown aetiology. 300 children out of 100 000 need treatment. Treatment duration is till the end of the patient’s growth age (till the ossification of the skeleton) and the brace should be worn 23 hours a day. Problems with brace are: heat, moist,
CLOTHING INSULATION AND THERMAL COMFORT IN AFRICA: CURRENT STANDARDS AND APPLICABILITY
Background: The adoption of air conditioning (AC) is growing rapidly in developing countries across the world which puts a high burden on electricity distribution systems. This development is mostly driven by income growth and building design, but also due to increasing outdoor temperatures and to provide indoor thermal comfort. Current indoor thermal comfort standards are based on western clothin
Species specific susceptibility testing for ß-lactam antibiotics. With special reference to staphylococci.
The main objective of this thesis was to identify methods for the detection of ß-lactam resistance in staphylococci, bacteria often causing nosocomial infections. Detection of ß-lactam resistance in these species is difficult due to strong regulation of genes encoding for the two main resistance mechanisms, ß-lactamase production and the penicillin-binding protein (PBP) 2?. ß-lactamase has high af
Conjugate Heat Transfer Enhancement Of An Internal Blade Pin-Finned Tip-Wall
To improve gas turbine performance, the operating temperature has been increased continuously. However, the heat transferred to the turbine blade is substantially increased as the turbine inlet temperature is increased. Cooling methods are therefore needed for the turbine blades to ensure a long durability and safe operation. The blade tip region is exposed to the hot gas flow and is difficult to
Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden
Background. The incidence and severity of invasive group A streptococcal infection demonstrate great variability over time, which at least, in part, seems to be related to group A streptococcal type distribution among the human population. Methods. An enhanced surveillance study of invasive group A streptococcal infection (746 isolates) was performed in Sweden from April 2002 through December 2004
Radiocesium in the forest and forest industry, Studies on the flow, occurrence and technological enhancement of radionuclides in the forest industry with emphasis on radiocesium.
In the aftermath of the nuclear weapons testing and as compared with agriculture, the forest industry has received relatively little attention in spite of its large-scale use of radiocesium- contaminated wood and water. After the Chernobyl nuclear power plant accident in 1986, numerous studies of the forest environment have been conducted with respect to radionuclide transfer through the forest ec
Investigation of Hydrogen Enriched Natural Gas Flames in a SGT-700/800 Burner Using OH PLIF and Chemiluminescence Imaging
The effect of hydrogen enrichment to natural gas flames was experimentally investigated at atmospheric pressure conditions using flame chemiluminescence imaging, planar laser-induced fluorescence of hydroxyl radicals (OH PLIF) and dynamic pressure monitoring. The experiments were performed using a 3rd generation dry low emission (DLE) burner used in both SGT-700 and SGT-800 industrial gas turbines
Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus
A Risk for Hepatocellular Carcinoma Persists Long-term After Sustained Virologic Response in Patients With Hepatitis C-Associated Liver Cirrhosis
Background. The long-term effect of sustained virologic response (SVR) to antiviral therapy on the risk of developing hepatocellular carcinoma (HCC), liver complications, liver-related death, and overall death in hepatitis C virus (HCV)-infected patients with liver cirrhosis is not fully known. Methods. These risks were evaluated during long-term follow-up in 351 patients with HCV-related cirrhosi
Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: Studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in patients with systemic lupus erythematosus
Objective To assess the efficacy of paquinimod, a new immunomodulatory small molecule, in a murine lupus model, and to evaluate its pharmacokinetics and tolerability in systemic lupus erythematosus (SLE) patients at doses predicted to be efficacious and safe and determine the maximum tolerated dose. Methods The efficacy of paquinimod was studied in lupus-prone MRL-lpr/lpr mice and compared with th
Clonal alteration of breast cancer receptors between primary ductal carcinoma in situ (DCIS) and corresponding local events
Background: Emerging data propose biomarker alteration due to clonal selection between the primary invasive breast cancer and corresponding metastases. In addition, impact on survival has been demonstrated. The present study investigates the relationship between the oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between primary ductal carcin
Drumlinised glaciofluvial and glaciolacustrine sediments on the Småland peneplain, South Sweden – new evidence on the growth and decay history of the Fennoscandian Ice Sheets during MIS 3
Dug trenches in sediment-cored drumlins on the Småland peneplain, southern Sweden, occurring intermixed with rock-cored drumlins, revealed sedimentary successions and facies suggesting that the core sediments were primarily deposited proglacially, both in glaciolacustrine settings as delta-front and more distal deeper-water sediments, and as glaciofluvial braidplain sediments. From the relationshi
DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study
Background The contribution of genetic variation in DNA repair genes to gastric cancer (GC) risk remains essentially unknown. The aim of this study was to explore the relative contribution of DNA repair gene polymorphisms to GC risk and severe chronic atrophic gastritis (SCAG). Method A nested case control study within the EPIC cohort was performed including 246 gastric adenocarcinomas and 1175 ma
Rapid Proteome Analysis of Bronchoalveolar Lavage Samples of Lifelong Smokers and Never-Smokers by Micro-Scale Liquid Chromatography and Mass Spectrometry.
Background: The aim of this study was to determine whether relative qualitative and quantitative differences in protein expression could be related to smoke exposure or smoke-induced airway inflammation. We therefore explored and characterized the protein components found in bronchoalveolar lavage (BAL) fluid sampled from either lifelong smokers or never-smokers. Methods: BAL fluid samples obtaine
Interaction of sugars, polysaccharides and cells with boronate-containing copolymers: from solution to polymer brushes
Interaction of mono- and disaccharides, polysaccharide particles and yeast cells with boronate-containing copolymers (BCC) of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with NN-dimethylacrylamide (DMAA) or N-isopropylacrylamide (NIPAM) was studied. The binding of saccharides to BCC of NIPAM resulted in a shift of its phase transition temperature (Delta T-p), which provided a quantitative measur
Hypovolemia is a main factor behind disturbed perfusion and metabolism in the intestine during endotoxemia in cat.
Disturbances in intestinal metabolism and perfusion during SIRS can be direct effects of toxic substances, and/or effects secondary to hypovolemia. An attempt to evaluate the significance of hypovolemia for intestinal disturbances during SIRS was made in the present study on feline by evaluating the degree to which the intestinal alterations following endotoxin infusion were restored by a clinical
