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BACKGROUND: There is uncertainty about the relevance of animal foods to the pathogenesis of ischemic heart disease (IHD). We examined meat, fish, dairy products, and eggs and risk for IHD in the pan-European EPIC cohort (European Prospective Investigation Into Cancer and Nutrition). METHODS: In this prospective study of 409 885 men and women in 9 European countries, diet was assessed with validate
In recent years, the data science and remote sensing communities have started to align due to user-friendly programming tools, access to high-end consumer computing power, and the availability of free satellite data. In particular, publicly available data from the European Space Agency’s Sentinel missions have been used in various remote sensing applications. However, there is a lack of studies th
BackgroundChronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are characterized by persistent airway inflammation and airflow limitation. Measuring airway inflammation may be of value both in research and clinical practice. Calprotectin, a protein associated with neutrophil activation, serves as a potential biomarker for airway inflammation. This study evaluates the performance o
Despite national progress, stunting remains prevalent in specific regions of Rwanda, highlighting the limitations of coarse-resolution data for effective mapping and intervention planning. This study explored optimal spatial resolution and analytical approach to capture localised dynamics and the multifactorial nature of stunting. A cross-sectional, population-based study was conducted in the Nort
OBJECTIVE: It is unknown how risk factors for infection after transrectal prostate biopsy interact. We designed a study to evaluate this.METHODS: We identified biopsy procedures from 2006 to 2020 in the Swedish nationwide database PCBaSe. Primary outcome was post-biopsy infection, defined as a dispensed prescription of a urinary tract antibiotic and secondary outcome was inpatient care for infecti
BACKGROUND: Opioid-free anaesthesia (OFA) may enhance postoperative recovery after bariatric surgery, but its combined effect with opioid-free interventions has not been studied.OBJECTIVES: To compare postoperative pain and recovery after laparoscopic bariatric surgery with a total opioid-free care pathway and conventional opioid-based treatment.DESIGN: A multicentre nonblinded controlled trial.SE
BACKGROUND: The transition to undertaking rehabilitation in the home or local neighbourhood calls for an extensive understanding of which aspects of the built environment are important for people with stroke.OBJECTIVE: This qualitative study aims to explore how home and local neighbourhood environments support or hinder rehabilitation for people who have had a stroke from the perspectives of vario
Carbon-based materials are highly sought after due to their superior properties, making them valuable for high-performance applications. However, most carbon-based materials are derived from fossil sources, and their synthesis often involves hazardous chemicals. Therefore, it is essential to develop sustainable methods for synthesising these materials from renewable resources, using fewer solvents
Objective: To investigate the feasibility of active heart sparing (AHS) planning in patients with locally advanced and centrally located NSCLC receiving standard definitive radiotherapy (RT), while maintaining or improving appropriate lung, esophagus, and spinal cord constraints and planning target volume (PTV) coverage intent. Methods and materials: A total of 27 patients with stage IIIA/B NSCLC
Background: Type 2 diabetes (T2D) and dementia represent a growing dual burden in aging populations. These conditions share pathophysiological mechanisms that may create a self-reinforcing cycle in which cognitive impairment affects diabetes management, a crucial factor for preventing complications. Despite Sweden's comprehensive care, there is limited longitudinal evidence on how cognitive
The recast Energy Performance of Buildings Directive introduces binding Minimum Energy Performance Standards for existing non-residential buildings, requiring Member States to identify and renovate the worst-performing segments of their building stock. This study develops and applies an integrated framework for evaluating energy renovation measures in office buildings, addressing building category
As offshore wind farms continue to grow in scale and number, wake interaction between turbines represents a significant source of power loss and increased fatigue risk. Consequently, there has been an increased interest in wake control strategies. Wake control strategies aim to mitigate these effects but their comparative effectiveness across power, wake velocity and turbulence intensity is not we
Background and Objectives – Pyruvate dehydrogenase complex (PDHc) deficiency is a potentially treatable neurodegenerative genetic disorder. It represents a common cause of mitochondrial disease. Most published reports are limited to single cases, and population-based data are lacking. The objective of this study was to investigate the prevalence, incidence, and life expectancy and to explore genot
This dissertation investigates the reliability boundaries of optical photothermal infrared spectroscopy (O-PTIR) for semi-quantitative β-sheet analysis and its application to the detection of Parkinson’s disease (PD)-related skin biomarkers. The work is divided into two sub-projects. Sub-project I used atomic force microscopy–infrared spectroscopy (AFM-IR) as a reference technique to systematical
Background: Vasovagal syncope (VVS) is a common yet challenging condition with limited effective treatments. Elastic compression stockings (ECS) have been proposed as a potential therapy, but their real-world effectiveness remains unclear. Objectives: This study sought to compare the effectiveness of lower extremity compression with thigh-high ECS vs sham stockings for the prevention of VVS recurr
Background: Knee pain is often an early sign of knee osteoarthritis (KOA). Physical activities (PA) constitute the recommended regime to those affected. However, knee-loading PA at work is linked to an increased risk for KOA. The primary aim of this study was to investigate associations between knee pain and accelerometer-measured knee-loading PA, at work and leisure respectively. The secondary ai
Fine-grained windblown deposits, known as loess, in which fossil soils (palaeosols) are preserved, serve as excellent records of past climate. However, paleoclimate reconstruction studies on loess-palaeosol sequences (LPS) in Southeastern Europe have primarily focused on climate changes during the last one or two glacial-interglacial cycles. Surprisingly, little attention has been given to the cli
