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1. In the present study we compared neuropeptide Y (NPY) and NPY-related analogues for their ability to activate or bind to vascular NPY receptors in four experimental set-ups. Previous results have suggested the existence of different receptor subtypes, Y1 receptors requiring full-length NPY (1-36) or [Pro34]-NPY, and Y2 receptors recognizing also N-terminally truncated forms of NPY but not [Pro3
OBJECTIVE - To determine the effects of islet cell antibodies on β-cell function during the first 3 yr after diagnosis in type II diabetic patients. RESEARCH DESIGN AND METHODS - β-cell function in type II diabetic patients with (n = 11, 50 ± 5 yr of age) and without (n = 10, 52 ± 4 yr of age) ICA was followed prospectively and compared with β-cell function in type I adult diabetic patients (n = 1
Background: Due to advances in hip arthroscopy, the number of surgical procedures has increased dramatically. The diagnostic challenge in patients with longstanding hip and groin pain, as well as the increasing number of hip arthroscopies, may lead to a higher number of patients referred to tertiary care for consideration for surgery. Therefore, the aims were: 1) to describe the prevalence of hip-
The main objective of the study was to investigate the thermal performance of five (open and closed) bicycle helmets for convective and evaporative heat transfer using a nine-zone thermal manikin. The shape of the thermal manikin was obtained by averaging the 3D-point coordinates of the head over a sample of 85 head scans of human subjects, obtained through magnetic resonance imaging (MRI) and 3D-
Importance: Low academic achievement (AA) in childhood and adolescence is associated with increased substance use. Empirical evidence, using longitudinal epidemiologic data, may provide support for interventions to improve AA as a means to reduce risk of drug abuse (DA). Objective: To clarify the nature of the association between adolescent AA and risk of DA by using instrumental variable and co-r
Aims/hypothesis: Growth differentiation factor 15 (GDF-15) is an anti-inflammatory cytokine of the transforming growth factor-β superfamily. Circulating levels of GDF-15 are associated with hyperglycaemia among people with obesity or diabetes, but longitudinal evidence on the association between GDF-15 levels and diabetes risk is scarce. Our aim was to explore whether circulating levels of GDF-15
This work aims to study the flow of non-Newtonian fluids and has two main goals. First, the power-law and Herschel Bulkley fluids are studied in a Couette rheometer. Second, the static and dynamic interaction of dual particles in power-law fluid are investigated.For the first goal, Computational Fluid Dynamics (CFD) is employed to understand the flow behavior of powe-rlaw fluid in the Couette rhe
Cranial radiotherapy is a known risk factor for neurocognitive impairment in survivors of childhood acute lymphoblastic leukemia (ALL). Understanding the nature of cognitive dysfunction during adulthood in ALL survivors is important as it has an impact on major life situations. Thirty-eight (21 women) ALL survivors were investigated 34 years after diagnosis. Median-age was 38 (27–46) years. All we
BACKGROUND: We investigated the potential associations between cerebro-spinal fluid (CSF) levels of phosphorylated tau (P-tau) and total tau (T-tau) with short-term response to cholinesterase inhibitor (ChEI) treatment, longitudinal outcome and progression rates in Alzheimer's disease (AD). METHODS: This prospective, observational study included 129 participants clinically diagnosed with mild-to-m
Cancer development depends on cells aquiring a skillset of limitless growth and finally invasive properties to allow for metastasis, as summarised by the six hallmarks of cancer. Recently four more hallmarks have been added: genomic instability, deregulating cellular metabolism, tumour-promoting inflammation and avoiding immune destruction. This thesis focuses on the latter two: immune system and
Background: Women's fears and attitudes to childbirth may influence the maternity care they receive and the outcomes of birth. This study aimed to develop profiles of women according to their attitudes regarding birth and their levels of childbirth related fear. The association of these profiles with mode and outcomes of birth was explored.Methods: Prospective longitudinal cohort design with self
It is now becoming increasingly clear that free radicals contribute to brain damage in several conditions, such as hyperoxia and trauma. It has been more difficult to prove that free radical production mediates ischemic brain damage, but it has often been suggested that it may be a major contributor to reperfusion damage, observed following transient ischemia. Recent results demonstrate that cereb
Based on a large number of new boreholes in northern Denmark, and on the existing data, a revised event-stratigraphy is presented for southwestern Scandinavia. Five significant Late Saalian to Late Weichselian glacial events, each separated by periods of interglacial or interstadial marine or glaciolacustrine conditions, are identified in northern Denmark. The first glacial event is attributed to
Popular Abstract in Swedish Med snabbare och pålitligare analysresultat finns stora möjligheter till ett ökat utnyttjande av avfallsresurser för produktion av förnybar energi. Resultat från min forskning gör det möjligt att analysera råvaror för biogasproduktion med större säkerhet och med möjligheten att få upp till nio gånger snabbare resultat. Produktion av biogas har under den senaste tiden öA sustainable treatment of organic wastes, generation of renewable energy, reduction of green house gas emissions, limiting the eutrophication and closing the nutrient cycles are several environmental challenges for which anaerobic digestion may be a suitable solution. There is today a large amount of available organic waste materials that could serve as potential feedstock for biogas production.
Selektiv distribution är en distributionsform som innebär att de produkter som säljs inom systemet endast säljs till auktoriserade grossister och återförsäljare. De får i sin tur endast sälja till andra auktoriserade aktörer inom systemet eller till slutkund. För att bli auktoriserad ställs vanligtvis höga krav. De gäller bland annat krav på utbildad personal, försäljningsställets utformning och l
En av de viktigaste grundstenarna inom EG-rätten är skapandet av en gemensam marknad. Varumärkesrätten är en territoriellt begränsad rättighet som kan utnyttjas för att hindra parallellimport av produkter inom EU. Detta leder naturligtvis till konflikter mellan principen om fri rörlighet för varor och varumärkesinnehavarens intressen. EG-domstolen har i en rad rättsfall försökt skapa en balans mel
Earlier studies show that different concrete aggregates have different thermal properties, and from this an idea to optimize thermal properties of concrete was developed. The purpose of this master thesis is to investigate thermal properties of concrete so additional costs and negative environmental impacts can be minimized. Measurements of thermal properties of different Swedish aggregates from e
Glulam is almost exclusively the chosen material of timber frame structures. Of those, three-hinged (three-pin) portal frames are incomparably the most common type. Being both statically determinate and stable against horizontal forces in its own plane offer both practical (basic constructive details) and economical benefits. The design of the haunch allows for various solutions: it can be curved
