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Endogenous modulators of hyperexcitability in epilepsy: electrophysiological and optogenetic delineation of neuropeptide Y mechanisms in interneurons

Epilepsy is one of the most common neurological disorders worldwide, affecting 1% of the general population, and is characterized by a predisposition for the generation of epileptic seizures. Despite having several different aetiologies, a common underlying cause of epilepsy seems to be an acquired imbalance between excitatory and inhibitory circuits in the brain, which leads to hyperexcitability

Physiology of Industrially Relevant Bacteria: Freeze-drying tolerance of Lactobacillus reuteri and Pseudomonas chlororaphis and product formation of Lactococcus lactis metabolizing maltose

When the metabolic activity of bacteria is exploited by the food and biotechnology industries, freeze-drying is commonly used to produce concentrated bacterial cultures with enhanced storage stability. The freeze-drying tolerance of the probiotic strain Lactobacillus reuteri and the biocontrol agent Pseudomonas chlororaphis has been characterized in this work. Lb. reuteri was found to have higher

THE VASOPRESSIN SYSTEM IN DIABETES MELLITUS, OBESITY AND THE METABOLIC SYNDROME

Background: Animal studies suggest that the arginine vasopressin (AVP) system plays a role in glucose and fat metabolism, but data from humans are limited. Method and results: We analysed plasma copeptin (copeptin), a stable C-terminal fragment of the AVP pro-hormone in the large, Swedish, population-based cohort Malmö Diet and Cancer Study Cardiovascular Cohort (MDC-CC, n=6103). Using baseline

Neurogenesis and transplantation in stroke-damaged brain

Popular Abstract in Swedish Stroke hos unga vuxna råttor och möss utlöser neurogenes i den skadade regionen striatum samt i den intakta hippocampus, men eftersom stroke framförallt drabbar äldre individer, är det av största vikt att utröna åldrandets effekt på hjärnans mekanismer för återhämtning. Gamla och unga vuxna råttor inducerades med stroke genom transient ocklusion av mellersta hjärnartäreStroke in young adult rodents triggers neurogenesis in the damaged striatum and intact hippocampus. as stroke happens frequently in aged individuals it is of great importance to know whether aging affects brain recovery mechanisms. Aged and young adult rats were subjected to stroke by transient occlusion of the middle cerebral artery and proliferating cells were labeled by intraperitoneal administ

The effect of assembly tolerance on performance of a tape application task: A pilot study

Task characteristics such as visual and manual demands influence the postures employed and the muscular load during task execution. According to ergonomic experts at a car assembly plant, these demands are difficult to predict during product and production development and can easily be underestimated. One such task with combined visual and manual demands is the application of deco-tape to the door

Multifunctional silk: from fabrication to application

Silk fibers offer untapped internal structures to template the formation of nano-objects and active coatings. So far, access to all or part of the internal and organized structures has been a significant challenge. The aim of the thesis is, therefore, to identify and exploit silk templating ability to create value-added multifunctional hybrid materials with enhanced conductive and catalytic proper

Male factor infertility and risk of death : a nationwide record-linkage study

STUDY QUESTION: What is the risk of death among men with oligospermia, unspecified male factor and azoospermia in the years following fertility treatment? SUMMARY ANSWER: No significantly elevated risk was observed among men with oligospermia and unspecified male factor, while an increased risk was found among men with azoospermia. WHAT IS KNOWN ALREADY: Previous studies have shown associations be

Interaction of barbiturates of various pharmacological categories with benzodiazepine receptors

Numerous barbiturates, such as (±)-pentobarbital, reversibly enhance the affinity for equilibrium binding of [3H]diazepam to well-washed rat cortical membranes in a chloride-dependent and picrotoxinin-sensitive manner [Leeb-Lundberg et al., Proc. Natl. Acad. Sci. U.S.A. 77:7468-7472 (1980)]. The chemical specificity and stereospecificity of this barbiturate effect in vitro has been examined in det

Lymph node CXCL17 messenger RNA : A new prognostic biomarker for colon cancer

Lymph node metastasis is the most important prognostic characteristic of colorectal cancer. Carcinoembryonic antigen messenger RNA was shown to detect tumor cells that have disseminated to lymph nodes of colorectal cancer patients and to be at least as good as the hematoxylin and eosin method to predict survival in colorectal cancer patients. CXCL17 was recently shown to be ectopically expressed i

Comparative analysis of root growth modules in HYDRUS for SWC of rice under deficit drip irrigation

Root distribution during rice cultivation is a governing factor that considerably affects soil water content (SWC) and root water uptake (RWU). In this study, the effects of activating root growth (using growth function) and assigning a constant average root depth (no growth during simulation) on SWC and RWU for rice cultivation under four deficit drip irrigation treatments (T90, T80, T70, and T60

Detection of Mycobacterium tuberculosis complex DNA in CD34-positive peripheral blood mononuclear cells of asymptomatic tuberculosis contacts : an observational study

Background: Haematopoietic stem cells expressing the CD34 surface marker have been posited as a niche for Mycobacterium tuberculosis complex bacilli during latent tuberculosis infection. Our aim was to determine whether M tuberculosis complex DNA is detectable in CD34-positive peripheral blood mononuclear cells (PBMCs) isolated from asymptomatic adults living in a setting with a high tuberculosis

Schedule

Schedule | Centre for Mathematical Sciences Skip to main content This site uses cookies to enhance the user experience. By continuing to use the site you agree that cookies are used according to our Cookie Policy (on the website of LTH) . Essential cookies These cookies are necessary for the website to function and cannot be turned off in our systems. These cookies do not store any personally iden

https://www.maths.lu.se/english/education/mathematics-bachelors-programme/schedule/ - 2026-06-06

Schedule

Schedule | Centre for Mathematical Sciences Skip to main content This site uses cookies to enhance the user experience. By continuing to use the site you agree that cookies are used according to our Cookie Policy (on the website of LTH) . Essential cookies These cookies are necessary for the website to function and cannot be turned off in our systems. These cookies do not store any personally iden

https://www.maths.lu.se/english/education/mathematics-masters-programme/schedule/ - 2026-06-06

All Courses

All Courses | Centre for Mathematical Sciences Skip to main content This site uses cookies to enhance the user experience. By continuing to use the site you agree that cookies are used according to our Cookie Policy (on the website of LTH) . Essential cookies These cookies are necessary for the website to function and cannot be turned off in our systems. These cookies do not store any personally i

https://www.maths.lu.se/english/education/courses/ - 2026-06-06

Cycle characterisation and clinical complications in patients with cyclic Cushing's syndrome: insights from an international retrospective cohort study

Background: Cyclic Cushing's syndrome (cCS) features fluctuating cortisol secretion, often causing diagnostic errors or delays, and possibly poorer outcomes. We aimed to identify unpublished cCS cases to characterise clinical challenges and guide strategies for improving outcomes by characterising cycle patterns, peak frequency, and evaluating complications. Methods: This was a retrospective obser

Head Acceleration Magnitude in Sport-Related Concussive Impacts: A Systematic Review and Meta-analysis

Background: Sport-related concussion (SRC) is a common and complex injury in athletic populations. Linear head acceleration (LHA) and rotational head acceleration (RHA) are key biomechanical factors believed to contribute to SRC, each through distinct mechanisms. Evaluating head impact magnitudes across different sports, athlete populations, and measurement methods is essential for advancing SRC i

Temperaturens inverkan på relativ fuktighet i betong - Materialkarakterisering av betong med vulkanisk puzzolan

Betong är ett av byggsektorns mest använda material, men cementproduktionen står för stora koldioxidutsläpp. Ett sätt att minska klimatpåverkan är att reducera andelen cementklinker genom att använda alternativa bindemedel. Vulkanisk puzzolan från Island, VPI är ett tillsatsmaterial från Heidelberg Materials Cement Sweden som kan användas tillsammans med cement som bindemedel i betong. TillsatsmatConcrete is one of the most widely used materials in the construction sector, but cement production is associated with a significant climate impact. One way to reduce this impact is to decrease the proportion of cement clinker by using alternative binders. Volcanic pozzolan from Iceland, VPI, is a supplementary material supplied by Heidelberg Materials Cement Sweden that can be used together with

Master thesis cover 2

CONSTRUCTION OF MONOTONE SMOOTHING SPLINES USING A BRANCH AND BOUND METHOD BERÄKNING AV MONOTONA UTJÄMNANDE SPLINES MED EN BRANCH AND BOUND-ALGORITM MALTE LARSSON Master’s thesis 2020:E38 Faculty of Engineering Centre for Mathematical Sciences Mathematics C EN TR U M SC IEN TIA R U M M A TH EM A TIC A R U M Construction of monotone smoothing splines using a branch and bound method Malte Larsson

https://www.lu.se/sites/www.lu.se/files/master_thesis_cover_2.pdf - 2026-06-06