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Plasma proenkephalin A 119-159 on intensive care unit admission is a predictor of organ failure and 30-day mortality

BACKGROUND: Proenkephalin A 119-159 (penKid) has been suggested as a marker of renal failure and poor outcome. We aimed to investigate the association of penKid on ICU admission with organ dysfunction and mortality in a mixed ICU population. In this retrospective, observational study, admission penKid levels from prospectively collected blood samples of consecutive patients admitted to four Swedis

3D cadastral visualization and integration of CityGML3.0 with Land Administration Domain Model

During the last years, virtual 3D city models have been widely used in application fields such as urban planning, environment simulations, and disaster management. With the development of high-rise buildings and the increasing densely built-up areas, an increasing number of authorities and companies have shown interest in integrating 3D city models with the cadastre. This is because on one hand, t

Capital structure and firm performance: A study on Sweden’s OMX30 index

The purpose of this thesis is to examine the relationship between varying leverage ratios and performance for large Swedish firms. With a recent trend of decreasing borrowing rates, it is more common for Swedish firms to have a larger portion of debt on their balance sheets. This trend makes it important to understand the effects changing leverage has on firm performance. The relationship between

The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking

The large protein family called G Protein-coupled receptors (GPCRs) has co-evolved with life throughout evolution; from single cell organisms all the way to complex beings such as us humans. The fact that GPCRs are involved in essentially every physiological event, and that ~50% of drugs on the current market are either directly or indirectly targeted towards the function of GPCRs, we can be certa

Linking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma

Purpose: The available questionnaires for quality-of-life (QoL) assessments are age-group specific, limiting comparability and impeding longitudinal analyses. The comparability of measurements, however, is a necessary condition for gaining scientific evidence. To overcome this problem, we assessed the viability of harmonising data from paediatric and adult patient-reported outcome (PRO) measures.