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Adoptive T-cell therapy (ACT) is a highly intensive immunotherapy regime that has yielded remarkable response rates and many durable responses in clinical trials in melanoma; however, 50-60% of the patients have no clinical benefit. Here, we searched for predictive biomarkers to ACT in melanoma. Whole exome-and transcriptome sequencing and neoantigen prediction were applied to pre-treatment sample
The segmentation and separation of objects in 3D medical imaging, particularly in Computed Tomography (CT), are essential for accurate diagnostics and preoperative planning. This master's thesis presents a tool for the interactive and automatic separation of segmented bones in CT scans, using the Random Walker algorithm and neural networks. The tool was developed to address challenges such as
Yoghurt is a fermented product form the milk, well known in the world. The fermentation is carried out by Lactic acid bacteria (LAB). The most common are Streptococcus thermophilus and lactobacillus bulgaricus, these bacteria make the milk acid, generating a disturbance in the casein micelles making a solid mass called coagulum. This specific LAB also produces expopolysaccharides (EPS) that form t
Camping is a popular form of outdoor recreation practiced worldwide, with different individuals and groups utilizing various transportation, equipment, and values. This report aims to identify the diverse types of campers and their needs, with the goal of finding a solution that can fit into Thule‘s product portfolio. The report considers factors such as the intended location, transportation, pu
This essay focuses on the verse 3:28 from Paul´s letter to the Galatians, in which Paul writes that “There is neither Jew nor Greek, there is neither slave nor free, there is neither male nor female; for you are all one in Christ Jesus.” I have chosen to focus, primarily, on the concepts of “male nor female” in a combined exegetical study and hermeneutical search for an inclusive, Pauline language
Testicular germ cell cancer is preceded by a pre-invasive stage called carcinoma-in-situ (CIS). The majority, if not all cases of CIS will progress into invasive cancer. Today, the only reliable way of diagnosing CIS is by performing open testicular biopsy. There is an ongoing search for non-invasive techniques for diagnosing early testicular neoplasia. The possibility of using ultrasound of the t
Purpose: To evaluate the neurophenomenology of automatic writing (AW) in a spontaneous automatic writer (NN) and four high hypnotizables (HH). Methods: During fMRI, NN and the HH were cued to perform sponta- neous (NN) or induced (HH) AW, and a comparison task of copying complex symbols, and to rate their expe- rience of control and agency. Results: Compared to copying, for all participants AW was
Photo-induced cross-linking of unmodified proteins (PICUP) has been used in the past to study size distributions of protein assemblies. PICUP may, for example, overcome the significant experimental challenges related to the transient nature, heterogeneity, and low concentration of amyloid protein oligomers relative to monomeric and fibrillar species. In the current study, a reaction chamber was de
A number of deleterious health effects have been identified from exposure to outdoor airborne particulate matter. Given that in developed countries we spend majority of our time indoors, in private homes about 65 % (Brashe et al., 2005), the understanding of this exposure is important, yet knowledge is sparse. Particle levels indoors are affected by indoor sources, infiltration from outdoors or pa
In contrast with human hemoglobin (Hb) in red blood cells, plant Hbs do not transport oxygen, instead research points towards nitrogen metabolism. Using comprehensive and integrated biophysical methods we characterized three sugar beet Hbs: BvHb1.1, BvHb1.2 and BvHb2. Their affinities for oxygen, CO, and hexacoordination were determined. Their role in nitrogen metabolism was studied by assessing t
This bachelor’s thesis explores the ethical challenges associated with the use of Artificial Intelligence (AI) in municipal social services in the Skåne region of Sweden. As AI technologies are increasingly adopted to improve efficiency and support decision-making, it is important to understand how ethical principles are upheld in practice. The study aimed to identify these challenges and examine
In the pursuit of more sustainable urban energy systems, recovering industrial waste heat presents a promising opportunity to enhance energy efficiency and reduce emissions. This thesis explores the technical and economic feasibility of capturing excess heat from an industrial process and repurposing it to supply a new low-temperature district heating network planned for a new residential district
This chapter is an attempt to trace the political–philosophical discourses of modernity and nationalism in Iran during the twentieth century. The aim is to understand the frameworks of political discourse at two points in time, 1920 and the present, and to analyze how these frameworks have changed. In short, while certain ideas seem to repeat themselves over time, the issue here is the salience of
Heroic narrations of Waffen-SS are encountered in several memory cultures, notleast among Cold War émigrés.1 One example of this is the Ukrainian communityin Canada, in particular the so-called third wave of Displaced Persons, refugeesfrom communist rule in Eastern Europe. It constitutes a community of memoryin many key respects at odds with the Canadian mainstream society. Whereas theHolocaust ocThe 14th Waffen-SS Division Galizien was set up in 1943 by Ukrainian volunteers, largely sympathetic to the more conservative Melnyk wing of the Organization of Ukrainian Nationalists (OUN(m)). Its members took a personal oath of allegiance to Adolf Hitler and served in a number of capacities on the eastern front. In addition to combat at the front, the unit partook in the crushing of the Slovak N
Today independent publishers are offering digital libraries with fulltext archives. In an attempt to provide a single user-interface to a large set of archives, the studied Article-Database-Service offers a consolidated interface to a geographically distributed set of archives. While this approach offers a tremendous functional advantage to a user, the fulltext download delays caused by the networ
Dispersive liquid-liquid microextraction (DLLME) and high performance liquid chromatography-diode array detection (HPLC-DAD) was presented for extraction and determination of Irganox 1010, Irganox 1076 and Irgafos 168 (antioxidants) in aqueous samples. Carbon tetrachloride at microliter volume level and acetonitrile were used as extraction and dispersive solvents, respectively. The main advantages
Previous work has shown that amylose (AM) can cross-link hydrophobically modified polymers by inclusion complexation, whereby thermoreversible cold-setting gels are formed. Here we investigate the complexation of AM with different samples of hydrophobically modified ethyl(hydroxyethyl) cellulose (HMEHEC), distinguished by differences in the architecture of the hydrophobes (the hydrophobic side cha
OBJECTIVES: This study assessed the health effects of occupational acrylamide exposure using hemoglobin (Hb) adducts as biomarkers of internal dose. METHODS: Two hundred and ten tunnel workers exposed for about 2 months to a chemical-grouting agent containing acrylamide and N-methylolacrylamide underwent a health examination. Blood samples were drawn for the analysis of Hb adducts of acrylamide. F
Evidence supports an important role for beta-amyloid (A beta) in the pathogenesis of Alzheimer's disease ( AD). Here, we investigate baseline levels of the 40- and 42-amino-acid-long A beta peptides (A beta 40 and A beta 42) in cerebrospinal fluid (CSF) from a cohort of patients with mild cognitive impairment (MCI, n = 137) in relation to the final diagnosis after 4 - 6 years of follow-up time. CS
