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In recent years, high-speed railway has been on the upswing in the public debate, as Swedish authorities have affirmed the plans of a high-speed corridor connecting Stockholm, Gothenburg and Malm¨o. The track speed limit is not fully determined, but will be in the range of 250-320 km/h. At these higher speed levels, it is harder to ensure traffic safety and passenger comfort, and dynamic analyses
Introduction: Obesity and health complications surrounding it have been on rise for a long time due to various factors where lifestyle is one of the most certain causes. Individuals following poor diet, specifically the western pattern diet or anything that comprises an excess of sugars and fats are prone to cardiometabolic diseases. Thus, modifications in the diet have the potential to prevent th
I vårdnadsmål ska utgångspunkten för domstolens bedömning vara barnets bästa. Enligt 6 kap. 2 a § föräldrabalken ska man särskilt beakta risken för att barnet far illa samt barnets behov av en nära och god kontakt med båda sina föräldrar. Det kan därför uppstå situationer där en förälder har varit våldsam mot barnet eller någon annan i familjen medan den andra föräldern hindrat umgänge mellan barnIn court cases concerning custody, the starting point for the court’s assessment must be the child’s best interests. According to 6 chapter 2 a § of the Parental Code, special attention must be brought to the risk of the child being subjected to harm, as well as the child’s needs of a good and close contact with both of its parents. Since these shall be assessed equally, situations may arise where
Social economy organisations are attributed a major role in solving societal and environmental problems and in implementing social innovations in Europe. These organisations are private entities running economic activities whose main purpose is to provide goods and services to their members or the community at large, with profits coming second. Nevertheless, these organisations are not suffici
General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investig
Popular Abstract in Swedish INTRODUKTION Aminosyror är en grupp små molekyler som finns i våra celler. Totalt finns det tjugo olika aminosyror, vilka kan binda till varandra i långa kedjor varvid de bildar proteiner (äggviteämnen). Proteiner ansvarar för en lång rad funktioner i organismen och varje cell i en organism måste därför kunna syntetisera ett par tusen olika proteiner för att kroppen ska1-microglobulin is a small glycoprotein present in plasma and in tissues surrounding the gastrointestinal and respiratory tracts. a1-microglobulin is a member of the lipocalin protein family and exhibits several of the typical traits of a lipocalin; it binds an unknown ligand which causes the brown color of the protein, it forms complexes with various different proteins and there have been indica
Global regulatory circuits together with more specific local regulators play a notable role when cells are adapting to environmental changes. Lactococcus lactis is a lactic acid bacterium abundant in nature fermenting most mono- and disaccharides. Comparative genomics analysis of the operons encoding the proteins and enzymes crucial for catabolism of lactose, maltose and threhalose revealed an obv
Introduction. The European Multiple System Atrophy-Study Group (EMSA-SG) is an academic network comprising 23 centers across Europe and Israel that has constituted itself already in January 1999. This international forum of established experts under the guidance of the University Hospital of Innsbruck as coordinating center is supported by the 5th framework program of the European Union since Marc
Objective. To study lymphocyte markers in rheumatoid arthritis (RA)-associated interstitial pneumonitis (IP) compared with idiopathic IP. Methods. Paraffin-embedded lung biopsy specimens from patients with RA (n = 15) and from those without RA (n = 16), all of whom had a diagnosis of either nonspecific IP or usual IP, were studied. Tissue sections from each patient were reviewed by a pathologist,
Three methods are presented to calculate the load distribution in a chain drive containing two sprockets and one chain. The rollers, which are in contact with the sprockets, can move along the tooth flanks and their positions are given by force equilibrium. Since the positions of the rollers, and thereby also the load distribution, depend on the two connecting spans, it has been necessary to inclu
Objectives: To estimate the annual incidence rate of paediatric primary systemic vasculitis (PSV) in a defined geographical area in southern Sweden. Methods: Potential cases of PSV [IgA vasculitis (IgAV, Henoch–Schönlein purpura), Kawasaki disease (KD), granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), polyarteritis nodosa
Most of the common modeling approaches to premixed combustion in engineering applications are either based on the assumption of infinitely fast chemistry or the flamelet assumption with simple chemistry. The level-set flamelet library approach (FLA) has shown great potential in predicting major species and heat release, as well as intermediate and minor species, where more simple models often fail
Haemophilus influenzae är en bakterie som lever i människans luftvägar. Ofta orsakar bakterien ingen skada hos personen som bär den, men ibland orsakar H. influenzae luftvägsinfektioner såsom öroninflammation hos barn, akut försämring hos patienter med kroniskt obstruktiv luftvägssjukdom (KOL) samt lunginflammation. Bakterien kan också orsaka allvarliga infektioner såsom blodförgiftning och hjärnhHaemophilus influenzae is a common cause of respiratory tract infections such as acute otitis media (AOM), exacerbations of chronic obstructive pulmonary disease (COPD) and pneumonia. The species is subdivided into encapsulated and non-encapsulated strains, designated type a-f and nontypeable H. influenzae (NTHi), respectively. Prior to introduction of polysaccharide-protein conjugate vaccines aga
BACKGROUND: Before this study started, the standard postoperative chemotherapy regimen for stage II-III Wilms' tumour pretreated with chemotherapy was to include doxorubicin. However, avoidance of doxorubicin-related cardiotoxicity effects is important to improve long-term outcomes for childhood cancers that have excellent prognosis. We aimed to assess whether doxorubicin can be omitted safely fro
Perfusion eller genomblödning är termer som används för att beskriva blodflödet i kroppens allra minsta kärl. Information om perfusion kan vara av stor betydelse för att ställa diagnos vid vissa sjukdomar, eftersom blodet transporterar det syre och den näring som behövs för att upprättahålla vävnadens funktion i kroppen. Ett viktigt exempel där information om perfusion kan vara till nytta för att Exchange of oxygen and nutrients between blood and tissue occurs at the capillary level of the blood system. The blood volume flow rate in the capillaries is often referred to as perfusion, and knowledge about perfusion provides important information about the function and viability of the tissue, for example, in patients with ischaemic stroke, cancer, and neurodegenerative diseases.Dynamic suscep
Background: Psychiatric comorbidity is common in gambling disorder, a condition with low rates of treatment seeking. There is a paucity of documented nationwide data on gambling disorder and its co-occurring psychiatric comorbidities in the health care system. Methods: This is a nationwide register-based study of all patients aged above 18 years who were diagnosed with gambling disorder (correspon
Substance use disorders (SUDs) are important risk factors for suicide, yet little is known about how suicide risks vary by specific SUDs. We examined these risks for the first time in a large general population to facilitate comparisons across SUDs. A national cohort study was conducted of all 6,947,191 adults in Sweden. SUDs (opioid, sedative/hypnotic, hallucinogen, cannabis, amphetamine, cocaine
We hypothesized that a low grade in physical education (PE) is associated with an increased risk of future musculoskeletal conditions, especially chronic pain. Using a historical cohort study design, we identified all students (mean age 16.0years), who in 1974-1976 graduated from compulsory school in a Swedish municipality and retrieved their PE grades. We ensured that persons were still alive and
OBJECTIVE To investigate the primary pharmacology of fesoterodine (a novel antimuscarinic drug developed for treating overactive bladder) and SPM 7605 (its active metabolite, considered to be the main pharmacologically active principle of fesoterodine in man) against human muscarinic receptor subtypes, and to investigate in vitro and in vivo functional activity of these agents on the rat bladder c
