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Acquired hemophilia A is a rare bleeding disorder caused by autoantibodies to coagulation FVIII. Bleeding episodes at presentation are spontaneous and severe in most cases. Optimal hemostatic therapy is controversial, and available data are from observational and retrospective studies only. The EACH2 registry, a multicenter, pan-European, Web-based database, reports current patient management. The
Detection and removal of sentinel lymph nodes (SLN) is important in the diagnosis and treatment of cancer. The SLN is the first regional lymph node draining the primary tumor, and if the cancer has spread, it is most likely to find metastases in the SLN. In this study, we have for the first time been able to image the very same contrast agent, superparamagnetic iron oxide nanoparticles (SPIO-NPs),
BACKGROUND: The 2011 European Society of Cardiology guidelines state that acute coronary syndrome (ACS) may be excluded with a rapid 3 h high-sensitivity troponin T (HsTnT) sampling protocol. We aimed to evaluate the diagnostic and prognostic performance of HsTnT in patients with chest pain admitted with possible ACS in routine care. METHODS: A total of 773 consecutive patients admitted for in-hos
Purpose: Induced pluripotent stem cells (iPSCs) improve behavior and form neurons after implantation into the stroke-injured adult rodent brain. How the aged brain responds to grafted iPSCs is unknown. We determined survival and differentiation of grafted human fibroblast-derived iPSCs and their ability to improve recovery in aged rats after stroke. Methods: Twenty-four months old rats were subjec
One way to cool gas turbine tips is to design serpentine passages with 180A degrees turns inside the blades to fully utilize the coolant potential. It is therefore a desire to improve the cooling of the blade tips to ensure a long durability and safe operation. In the present work, a two-pass channel with a 180A degrees turn and various arrays of pin-fins mounted internally on the tip-cap is consi
Abstract in UndeterminedBACKGROUND: Work related fatigue has been suggested as a link in the assumed sequence of events between repeated adverse work demands and the development of work related stress, which may be associated with changes in concentrations of cortisol, psychological overload and, in the long run, health problems. Insufficient sleep is a contributing factor to lack of recovery, but
Blood plasma is the most complex human-derived proteome, containing other tissue proteomes as subsets. This proteome has only been partially characterized due to the extremely wide dynamic range of the plasma proteins of more than ten orders of magnitude. Thus, the reduction in sample complexity prior to mass spectrometric analysis is particularly important and alternative separation methodologies
Efficient direct electron transfer (DET) between a cellobiose dehydrogenase mutant from Corynascus thermophilus (CtCDH C291Y) and a novel glassy carbon (GC)-modified electrode, obtained by direct electrodeposition of gold nanoparticles (AuNPs) was realized. The electrode was further modified with a mixed self-assembled monolayer of 4-aminothiophenol (4-APh) and 4-mercaptobenzoic acid (4-MBA), by u
AIMS: The onset of clinical type 1 diabetes (T1D) is preceded by the occurrence of disease-specific autoantibodies. The level of autoantibody titers is known to be associated with progression time from the first emergence of autoantibodies to the onset of clinical symptoms, but detailed analyses of this complex relationship are lacking. We aimed to fill this gap by applying advanced statistical mo
The aim of the user related assessment of the VCC demonstrator’s “Traffic Jam Assist” system was to study trust, usefulness, perceived advantages, disadvantages, acceptance, and willingness to pay for the driver assistance system. The system provides automated speed control and lane keeping. If a lead vehicle is present, the automated vehicle adapts its speed in order to maintain a pre-set time di
We present a non-resonant, dual band circular polarization selective structure (CPSS) for satellite communication applications in the K- and Ka-band. The structure consists of multiple layers of cascaded anisotropic sheets, with printed meander lines, separated by low permittivity spacers. It reflects right hand circular polarization and transmits left hand circular polarization in the lower freque
BACKGROUND: Glutathione (GSH) is the major cellular redox-regulator and antioxidant. Redox-imbalance due to genetically impaired GSH synthesis is among the risk factors for schizophrenia. Here we used a mouse model with chronic GSH deficit induced by knockout (KO) of the key GSH-synthesizing enzyme, glutamate-cysteine ligase modulatory subunit (GCLM).METHODS: With high-resolution magnetic resonanc
Background: Traumatic brain injury is a common reason not only for emergency visits worldwide but also for significant morbidity and mortality. Several clinical guidelines exist but adherence is generally low. Aim: To study attitudes toward computed tomography of the head among emergency department Change to physicians throughout the article who manage patients with trauma to the head and doctors'
The behavior of Ethanol and seven fuels in the boiling point range of gasoline but with an Octane Number spanning from 69 to 99 was investigated in Partially Premixed Combustion. A load sweep was performed from 5 to 18 bar gross IMEP at 1300 rpm. The engine used in the experiments was a single cylinder Scania D12. To allow high load operations and achieve sufficient mixing, the compression ratio w
Background and purpose This study presents the evaluation of acute and late toxicities of the lung in children and adolescents after irradiation in terms of dose–volume effects. Materials and methods Irradiated children and adolescents in Germany have prospectively been documented since 2001 in the “Registry for the Evaluation of Side-Effects after Radiotherapy in Childhood and Adolescence (RiSK)”
BACKGROUND: Foot drop is common gait impairment after stroke. Functional electrical stimulation (FES) of the ankle dorsiflexor muscles during the swing phase of gait can help correcting foot drop. OBJECTIVE: To evaluate efficacy of additional novel FES system to conventional therapy in facilitating motor recovery in the lower extremities and improving walking ability after stroke. METHODS: Sixteen
Aim: The Swedish Social Board has implemented a support strategy to guide out-of-home care for children, which translates as children's needs in focus (CNIF) and includes a systematic health assessment. It was fully introduced into the Skåne province in 2012 and our study covered the first four years of the CNIF health assessments, from 2012 to 2015. Methods: We studied children aged 0–17 years in
Fungal (acetate-in-ergosterol incorporation) and bacterial (leucine/thymidine incorporation) growth resulting from alfalfa (C/N = 15) and barley straw (C/N = 75) addition was studied in soil microcosms for 64 days. Nitrogen amendments were used to compensate for the C/N difference between the substrates. Fungal growth increased to a maximum after 3–7 days, at five to eight times the controls, foll
It is shown how first-order performance estimation of high-orderadaptive optics (AO) systems may be efficiently implemented in a hybridnumerical simulation by the use of 1) sparse matrix techniques forwavefront reconstruction, 2) undersampled pupil-plane turbulence-inducedaberrations, and 3) analytical models that compensate - in the limit ofinfinite exposure time - for the errors introduced by un
