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A combination of acoustic trapping and impedance spectroscopy for micrometer-sized objects is here presented for the first time. Acoustic trapping has proven to be a well-functioning method for non-contact immobilization and positioning of particles or cells in microfluidic channels. The combination with impedance spectroscopy allows for simultaneous electrical measurements on the trapped objects.
TGFα is a member of the epidermal growth factor (EGF) family and is one of the ligands for the EGF- receptor. The precursor of TGFα, pro-TGFα, is a transmembrane protein. The aim of this project has been to establish a model for studies of pro-TGFα effects on EGF receptor signalling, in particular through Gab1, a docking protein involved in PI3K/Akt signalling pathway. The experiments in this thes
A variety of demand side management (DSM) methods are needed to ensure electric grid reliability and to integrate increasing shares of renewable energy sources into electricity networks. To investigate whether communal laundry rooms in Stockholm represent a good candidate for employing DSM to reduce the severity of electricity load peaks, tenants are surveyed on their willingness to temporarily lo
5-Hydroxymethylfurfural (5-HMF) is a furan-based platform chemical that can be used in various applications, as a renewable alternative to fossil-derived compounds or materials. It can be produced from biobased raw materials with high-sugar content, such as molasses. Sugar beet molasses is produced as a side product from domestic sugar beet plants in southern Sweden. Utilising it as a raw material
Abstract: The food consumption of today’s world has led to an overconsumption of the earth resources. It is easy to forget that when we consume we do not only consume a product we are also consuming other peoples labour and landscapes in, many times, far off places. With daily news on environmental damages, people are becoming more aware. Consequently, people are getting more interested in the ori
Små regulatoriska molekyler i vårt blod Sedan det mänskliga genomet kartlades i början av 2000-talet har stora upptäckter gjorts och teknikutvecklingen har gått fort. Dagens sekvenseringsmaskiner är kraftfulla och kan sekvensera hela det mänskliga genomet på bara två dagar. I mitt masterarbete har jag undersökt små korta RNA-molekyler i mänskligt blod. Denna typ av molekyler är mycket lovande somAbstract In recent years focused research aimed at finding new specific and sensitive biomarkers for detection, classification and, monitoring of human cancers has been ongoing. MicroRNAs (miRNAs) are small, 19-24 nucleotides, noncoding RNAs that are stably expressed in body fluids such as blood. These circulating RNAs have shown great promise as biomarkers, because the unique expression patterns
Abstract To develop a genetic system for the extreme thermophile Caldicellulosirruptor saccharolyticus is the next step in improving hydrogen productivities. Genetic systems are powerful tools to understand the metabolic network of the microorganism and to obtain high hydrogen productivities and yields. The primary aim of this project is to develop an expression vector for C. saccharolyticus. Pre
Sydvästra Grönlands arkeiska berggrund (North Atlantic Craton, NAC) intruderades av ett stort antal mafiska intrusioner och diabasgångar under arkeikum och proterozoikum, vars åldrar är dåligt kända. Detta arbete omfattar dateringar av fem intrusioner med U-Pb metoden av mineralen zirkon och baddeleyit från tre olika generationer av mafiska bergarter. En mafisk-ultramafisk lagrad intrusion i FiskeThe Archaean bedrock of southern Greenland (the North Atlantic Craton) is host to a large number of mafic intrusions and dyke swarms. This study present a robust U-Pb zircon age of 2990.1 ± 13 Ma for a mafic-ultramafic layered intrusion in the Fiskefjord region and four baddeleyite U-Pb ages of doleritic dykes that range between c. 2500 and c. 2050-2030 Ma. The dyke located SE of Ameralik Fjord is
Background: Open repair (OR) for popliteal artery aneurysm (PAA) has recently been challenged by endovascular repair (ER) as the primary choice of treatment. The aim of the present study was to evaluate time trends in treatment modality and compare outcomes between OR and ER among electively operated patients after start of screening in 2010 for abdominal aortic aneurysm (AAA), a disease highly as
Introduction: Trachoma is the leading infectious cause of blindness worldwide. It is more common in areas where people are socio-economically deprived. Although trachoma is endemic in 571 districts in Ethiopia, its prevalence has not been studied among school children in Harari Region. Objective: To assess the prevalence of trachoma eye infection and factors associated with it
Reactive oxygen species (ROS) are important contributors to the secondary injury cascade following traumatic brain injury (TBI), and ROS inhibition has consistently been shown to be neuroprotective following experimental TBI. NXY-059, a nitrone free radical trapping compound, has been shown to be neuroprotective in models of ischemic stroke but has not been evaluated in experimental TBI. In the pr
Purpose: The eyelid is commonly dissected and divided in the process of, for example, blepharotomy, entropion repair, or when preparing a full-thickness eyelid flap to reconstruct a tumor defect. No study has yet been conducted to examine how perfusion in an eyelid is affected by dissection, using modern imaging techniques. Methods: The eyelid was divided with a 10-mm vertical incision, 5 mm from
The main objective was to estimate the frequency of early vascular aging (EVA) in a sample of subjects from Latin America, with emphasis in young adults. We included 1416 subjects from 12 countries in Latin America who provided information about lifestyle, cardiovascular risk factors (CVRF), and anthropometrics. We measured pulse wave velocity (PWV) as a marker of arterial stiffness, and blood pre
Inference of antibody gene repertoires using transcriptome data has emerged as an alternative approach to the complex process of sequencing of adaptive immune receptor germline gene loci. The diversity introduced during rearrangement of immunoglobulin heavy chain variable (IGHV), diversity, and joining genes has however been identified as potentially affecting inference specificity. In this study,
