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Background: We have previously shown that podocalyxin-like protein (PODXL) is a prognostic biomarker for poor survival in gastric and esophageal adenocarcinoma treated with surgery up-front. The aim of the present study was to assess PODXL expression in tumors from patients treated with neoadjuvant ± adjuvant (i.e. preoperative with or without postoperative) chemotherapy, with regard to histopatho
OBJECTIVE: The aim of this study was to characterise the population pharmacokinetics of FE 999049, a novel recombinant human follicle-stimulating hormone (FSH), after multiple dosing in healthy women, taking into account endogenous FSH levels and the reproductive hormone dynamics.METHODS: Longitudinal measurements of FSH, luteinising hormone, progesterone, estradiol, and inhibin B levels were coll
This report describes a model for the estimation of the time required to evacuate a building, by dividing the evacuation process into three phases: awareness, behaviour and response, and movement. The times required in each of these phases can be estimated separately and the sum then represents the total evacuation time. The time elapsed from the fire breaking out, to the discovery of the fire, is
Objective: To study transitions from and to chronic widespread pain (CWP) over 7 years in patients with rheumatoid arthritis (RA). Method: Two postal questionnaires were sent to patients included in the BARFOT (Better Anti-Rheumatic Pharmacotherapy) study, the first in 2010 and the second in 2017. The questionnaires assessed pain, number of tender and swollen joints, functional disability, health-
This chapter reviews polarization vision in diverse crustaceans with a specific focus on work completed since the 2014 edition of this book. Almost all crustaceans are sensitive to the planar polarization of light. They commonly possess two channels of orthogonally arranged photoreceptors with intrinsically polarization-sensitive ordered microvilli. These two channels are compared to impart linear
Aims: Among patients with myocardial infarction (MI) with preserved left ventricular ejection fraction (LVEF), the REDUCE-AMI trial did not demonstrate a benefit of beta-blocker vs. no beta-blocker treatment on all-cause mortality and recurrent myocardial infarction. The aim of this pre-specified sub-study was to investigate effects of beta-blockers on self-reported symptoms of anxiety and depress
BACKGROUND: Continuity of care is important for patients with chronic conditions. Assigning patients to a named GP may increase continuity.AIM: To examine if patients who were registered with a named GP at the onset of their first chronic disease had higher continuity at subsequent visits than patients who were only registered at a practice.DESIGN & SETTING: Registry-based observational study
Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) is the most common congenital malformation of the upper digestive tract. This study represents the first genome-wide association study (GWAS) to identify risk loci for EA/TEF. We used a European case-control sample comprising 764 EA/TEF patients and 5,778 controls and observed genome-wide significant associations at three loci.
Eighty basal cell carcinomas (BCCs) in 21 patients, 10 lesions of Bowen's disease in three patients, and four lesions of cutaneous T-cell lymphoma in two patients, were treated with photodynamic laser therapy (PDT), using topical application of the haem precursor delta-amino levulinic acid (ALA). The diagnoses were confirmed histologically prior to treatment. Fifty-five of the BCCs were superficia
Purpose: Collaborative professional development for inclusive teaching is a limited area of research, although there is an extensive need for special educational needs and disabilities (SEND) teachers. Research findings of how teachers’ professional development can contribute to support the development of powerful learning situations for all students are presented in this special issue. The aim is
BackgroundGender stereotypes about women and men have a complementary structure, where women and men are seen as high/low in feminine characteristics and low/high in masculine characteristics. These stereotypes are related to representation within social roles, where beliefs about social role occupation influences which characteristics are associated with women or men. It is not known how people w
BACKGROUND: About 20% of adolescents experience substantial mental health problems after bariatric surgery.OBJECTIVES: The aim of this study was to explore differences between adolescents with poor mental health (PMH) 2 years after surgery and those with average/good mental health.SETTING: Three university hospitals in Sweden.METHODS: Mental health and health-related quality of life were assessed
Objectives: The impact of COVID-19 on gambling behavior and the gambling industry itself has been widely speculated. Prior studies have shown how boredom, social isolation, poor mental health, and financial hardships, all of which have been associated with COVID-19, can aggravate problem gambling behaviors in patients with gambling disorders while also luring newcomers. Few studies have used metho
Shape models and the automatic building of such models have proven over the last decades to be powerful tools in image segmentation and analysis. This thesis makes contributions to this field. The segmentation algorithm typically uses an objective function summing up contributions from each sample point. In this thesis this is replaced by the approximation of a surface integral which improves the
Study design: Psychometric study. Objectives: To i) describe the translation process and ii) explore the data completeness, targeting, reliability and aspects of validity of the Swedish version of Moorong Self-Efficacy Scale (s-MSES). Settings: Community rehabilitation program. Methods: Ninety-two program participants and 42 peer mentors with spinal cord injury (SCI) in Active Rehabilitation train
Uganda faces various challenges related to compliance, including tax evasion, regulatory non- compliance, and violations of legal standards, laws, policies and regulations among others. These issues undermine the government's ability to collect revenue, provide public services, and maintain law and order. Enhancing compliance is not only a matter of enforcing penalties but also involves creati
Non-native trees are common in urban environments all over the world. From a conservation viewpoint, it is essential to understand how these trees are affecting urban breeding birds. Non-native trees house fewer and smaller invertebrates than native trees do and are considered a poor food source for insectivorous birds. Still, studies are lacking on exactly how non-native trees affect birds’ feedi
Varje år går en tredjedel av all mat som produceras för mänsklig konsumtion till spillo världen över. I Sverige står livsmedelskedjan för en betydande del av landets totala klimatpåverkan. Det onödiga matavfallet, även kallat matsvinn, innebär att miljöpåverkan blir större än vad den hade kunnat vara. Matbanker, som tar tillvara på mat som av olika anledningar inte går att sälja och skänker den ti
Abstract Title Rethinking the balance sheet Seminar date 05 June 2015 Course FEKH89, degree project undergraduate level, Business Administration, 15 university credit points, ECTS Authors Victor Estwall, Hugo Oftedal and Andreas Åström Advisor Tore Eriksson Keywords Return on assets, firm performance, corporate finance, regression analysis, balance-sheet compositions Purpose The aim of this
Employment is a potential socioeconomic co-benefit of renewable energy deployment. However, renewable energy is often more expensive than conventional resources, putting pressure on the economy, and during an energy transition employments can be lost from the conventional energy sector, e.g. from phased out nuclear plants. The purpose of this study was to clear the field of whether a promotion of
