Filetype
The paper presents new geological, geochronological, geochemical, and Nd isotopic data on the late Paleoproterozoic dolerites of the Siberian craton. U-Pb baddeleyite ages of the Doros dolerites (Aldan shield, south-eastern Siberia) and East Anabar dolerites (Anabar shield, northern Siberia) are 1757 ± 4 and 1774 ± 6 Ma, respectively. This new geochronological data together with published 1.76–1.7
Background & Aims: RNA interference (RNAi) may offer new treatment options for chronic hepatitis B. Replicating via an RNA intermediate, hepatitis B virus (HBV) is known to be principally vulnerable to RNAi. However, beyond delivery, the relevant issues of potential off-target effects, target site conservation in circulating HBV strains, and efficacy of RNAi itself have not systematically been
Background/Aims: Our purpose was to investigate whether the new research criteria for Alzheimer's disease proposed in 2007 by Dubois et al. are valid in a naturalistic memory clinic sample. Method: Retrospective diagnostic analyses were carried out to compare the traditional diagnostic criteria for dementia with the new criteria suggested by Dubois et al. No patient had gone through all procedures
Quantification of land surface-atmosphere fluxes of carbon dioxide (CO2) and their trends and uncertainties is essential for monitoring progress of the EU27+UK bloc as it strives to meet ambitious targets determined by both international agreements and internal regulation. This study provides a consolidated synthesis of fossil sources (CO2 fossil) and natural (including formally managed ecosystems
Prostate-specific antigen (PSA) is a tissue-specific serine protease similar in structure to the trypsin-like glandular kallikreins but which is unique inasmuch as the enzyme activity is similar to that of chymotrypsin. The active enzyme is a single chain glycoprotein of 237 amino acids. The major form of PSA in serum is complexed to α1-antichymotrypsin (ACT). A small amount is free, non-complexed
INTRODUCTION: Plasma biomarkers offer promise for improving the diagnosis of Alzheimer's disease (AD) and differentiating AD and other neurodegenerative disorders (NDs) like frontotemporal dementia (FTD) from primary psychiatric disorders (PPDs), particularly in younger patients. METHODS: In this prospective study, we investigated plasma phosphorylated tau 217 (p-tau217), neurofilament light chain
Popular Abstract in Swedish Alla ryggradsdjur har ögon av en typ som kallas kameraöga. Som man kan höra på namnet så fungerar ett sådant öga ungefär som en kamera. En lins fokuserar ljuset på ett ljuskänsligt lager som i ett öga kallas för näthinna (retina). De ljuskänsliga cellerna i näthinnan heter tappar och stavar. Stavarna används för seende i mörker och tapparna används för seende i starkareMany fishes have well-developed visual systems with color vision capabilities. The crystalline lens is the major refractive element in a fish eye since the cornea is optically inactive underwater. A typical fish eye has a large pupil and a lens of short focal length, features that increase light gathering ability. They lead also to short depth of focus, which makes the eye particularly susceptible
In this study, a comprehensive investigation of a set of phytochemicals to identify potential inhibitors for the Forkhead box protein M1 (FOXM1) was conducted. FOXM1 is overexpressed in glioblastoma (GBM) cells and plays a crucial role in cell cycle progression, proliferation, and invasion. FOXM1 inhibitors have shown promising results in preclinical studies, and ongoing clinical trials are assess
Introduction: Several studies have addressed technical aspects of endovascular thrombectomy (EVT), but it is not well known how procedural factors contribute to technical success in routine healthcare. The aim was to explore factors associated with technically successful EVT on nationwide scale. Methods: We did an observational register-based study assessing factors associated with technical succe
User guide - National 7T facility Version 6, updated 2019-10-16 Responsible authors: Karin Markenroth Bloch (LBIC), Freddy Ståhlberg, Isabella Björkman-Burtscher 1 User guide National 7T facility Lund University BioImaging Center (LBIC), Lund University and Department of Medical Imaging and Physiology (BoF), Skåne University Hospital (SUS); Region Skåne User guide - National 7T facility Version 6,
https://www.lbic.lu.se/sites/lbic.lu.se/files/7t_user_guide_20191016.pdf - 2026-07-17
User guide - National 7T facility Version 6, updated 2019-10-23 Responsible authors: Karin Markenroth Bloch (LBIC), Freddy Ståhlberg, Isabella Björkman-Burtscher 1 User guide National 7T facility Lund University BioImaging Center (LBIC), Lund University and Department of Medical Imaging and Physiology (BoF), Skåne University Hospital (SUS); Region Skåne User guide - National 7T facility Version 6,
https://www.lbic.lu.se/sites/lbic.lu.se/files/7t_user_guide_20191023.pdf - 2026-07-17
My article deals with the work of the St Joseph Sisters in the Nordic countries, particularly in Denmark and Sweden, from the sisters’ arrival in 1856 to the 1920:ies. These Catholic sisters belonged to a French congregation called "La Congregation des Sœurs de Saint-Joseph de Chambéry", which was founded at the beginning of the nineteenth century and whose motherhouse was in Chambéry in Savoy. Th
Popular Abstract in Swedish Modellsystem för metall-DNA interaktioner Med fokus på anticanceraktiva platina(II) komplex Guld är ett mytomspunnet och fascinerande ämne som ger liv. Ett påstående som kanske förvånar, eftersom guld ofta förknippas med vackra smycken och rikedom. Att guld skulle ge liv var dock en förhoppning i Kina på 600-talet f. Kr. Där använde man nämligen metalliskt guld för medReactions of trans-dicyanodichloroaurate(III) trans-dibromodicyanoaurate(III), trans-diamminedichlorogold(III), cis-diammine(aqua)chloroplatinum(II), cis-ammineaqua-(cyclohexylamine)chloroplatinum(II), chloro(terpyridine)platinum(II) and chloro-(diethylenetriaminepalldium(II) with dimethyl sulfide, thionucleosides, thionucleotides and thione- and guanine-containing 17-mer oligonucleotides have bee
Energy consumption is today an important design issue for all kinds of digital systems, and essential for the battery operated ones. An important fraction of this energy is dissipated on the processors running the application software. To reduce this energy consumption, one may, for instance, lower the processor clock frequency and supply voltage. This, however, might lead to a performance degrada
Background. Umbilical artery Doppler velocimetry is a routine method for fetal surveillance in high-risk pregnancy. Uterine artery Doppler seems to give comparable information, but it can be difficult to interpret as there are two arteries, which might show notching and/or increased pulsatility index (PI) as signs of increased vascular impedance. Combining the information on vascular resistance on
The splice variant INS-IGF2 entails the preproinsulin signal peptide, the insulin B-chain, eight amino acids of the C-peptide and 138 unique amino acids from an ORF in the IGF2 gene. The aim was to determine whether levels of specific INS-IGF2 autoantibodies (INS-IGF2A) were related to age at diagnosis, islet autoantibodies, HLA-DQ, or both, in newly diagnosed type 1 diabetes patients and controls
The objectives of treatment in rheumatoid arthritis (RA) are to reduce temporary symptoms due to inflammatory activity and, more importantly, to preserve function. The introduction of potent disease-modifying anti-rheumatic drugs (DMARDs) in recent years has increased the opportunities for effective treatment. However, these treatments come at a substantially higher cost than traditional DMARDs an
We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) or internal pallidum (GPi-DBS) on health-related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a Subgroup of n = 20/20 patients with GPi-DBS and n = 45/49
This paper introduces a research project with the aim to develop concepts and tools for architectural design, taking the ideas of "behaviour settings" as a starting point, to enable a more relevant holistic view in object oriented design of buildings. In this paper we introduce the concept of "architectural object" as a representation of a real "situation" involving people, behaviour, experience a
