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Autophagy delivers cytoplasmic material for lysosomal degradation in eukaryotic cells. Starvation induces high levels of autophagy to promote survival in the lack of nutrients. We compared genome-wide transcriptional profiles of fed and starved control, autophagy-deficient Atg7 and Atg1 null mutant Drosophila larvae to search for novel regulators of autophagy. Genes involved in catabolic processes
Introduction ECG stress testing is an inexpensive and non-invasive detector of myocardial ischemia; addition of high-frequency QRS analysis (HFQRS) may improve accuracy. This study compared HFQRS during exercise in patients with and without ischemia as defined by multiple criteria. Material and methods High-resolution ECGs were recorded for 139 patients undergoing T99-sestamibi/T201-thallium stre
Popular Abstract in Swedish Svensk sammanfattning av avhandlingen: “Social Insurance, Organization and Hospital Care”. Denna avhandling handlar om incitament och organisation. Det inledande kapitlet sammanfattar avhandlingen samt diskuterar relaterad litteratur. Kapitel 2 är ett bidrag till den teoretiska litteraturen kring socialförsäkringar, kapitel 3 behandlar den optimala organisationen av triThis thesis consists of four chapters where chapter 1 introduces the topics in the following chapters and discusses some related literature. Chapter 2 moves beyond the disability insurance with two types, able and disabled, in Parsons (1996). This is done in two ways: by introducing a third type, the partially disabled, and by allowing for a continuum of types. It is assumed throughout that the i
In circumpolar regions, coastlines offer rich constellations of diverse resources, and have long been a focus of human habitation. Despite the rich archaeological records that are located along many northern coastlines, there is a relatively limited understanding of the range of factors that informed local settlement strategies. Northern Norway has one of the world’s longest and best-preserved arc
Inter-pigment interactions define the functioning of light-harvesting protein complexes. To describe the particularly complex molecular dynamics and interactions of peridinin and chlorophyll in the peridinin chlorophyll protein of Amphidinium carterae, we applied global and target analysis to a series of ultrafast transient absorption experiments. We have created and validated a model that consist
Popular Abstract in SwedishI den här avhandlingen är det övergripande syftet att analysera föreställningar om förändring med utgångspunkt i texter som tagits fram inom ramen för tre utvecklingspartnerskap som finansierades av den Europeiska socialfondens Equal-program 2001-2007. Utvecklingspartnerskapen, som bestod av flera samverkansparter från privat och offentlig sektor, syftade till att utveckIn this thesis the overall aim is to analyse conceptions of change with the point of departure being texts developed within the framework of three development partnerships financed by the European Social Fund's Equal Programme 2001-2007. The development partnerships, consisting of collaborating parties from both the public and private sector, aimed at developing new methods and ideas in order to c
“Is there a Nordic block, complete with a Nordic economic model and a special kind of Nordic welfare? Nordic collective security? Nordic values, Nordic sex, Nordic gloom? Undeniably the Nordic countries—the Scandinavian trio of Sweden, Denmark and Norway, plus Finland on the eastern flank and Iceland far north-west in the Atlantic—have a great many things in common. And undeniably the lure of the
Popular Abstract in Swedish Avhandlingen behandlar problemet hur sensoriska kvaliteter (kvalia) förhåller sig till neurala tillstånd och processer (en modern variant av det klassiska kropp-själ problemet). I avhandlingen presenteras en serie argument som avser att göra det troligt att problemen att begripa medvetandets materiella bas bottnar i en serie missförstånd och felaktiga analogier. AvhandlThis thesis is about the problem of how sensory qualities relate to neural states or processes. I shall try to present an account of why dualism appears to be an attractive and intuitive position, but also point out why dualistic intuitions may be misleading. A relatively common view in philosophy of mind is that accounts of how sensory qualities relate to neural states and processes involve an ex
Popular Abstract in Swedish Svenskan är ett s.k. V2-språk, dvs. det tempusböjda verbet står på andra plats i en deklarativ sats (en påståendesats) oavsett vilken typ av led som står i satsens första position. V1-ordföljd, där det tempusböjda verbet alltså står först i satsen, förknippas normalt med interrogativa satser (frågesatser) av typen ja/nej-frågor, t.ex. "Kommer du på fredag?". Icke desto The topic of the present thesis is V1 declaratives in spoken Swedish. Such constructions constitute an interesting object for research due to the fact that Swedish is a V2 language where V1 word order is grammaticalized for yes/no questions. Hitherto we have lacked a thorough study of the phenomenon. Therefore this thesis aims at investigating V1 declaratives in spoken Swedish from different point
Popular Abstract in Swedish Ärftlig blindhet orsakas oftast av sjukdomar där näthinnans fotoreceptorer, som ombesörjer omvandlingen av ljus till elektriska impulser, degenererar. Det anses att denna celldödsprocess styrs av ett antal olika mekanismer och projektets mål är att försöka identifiera och karaktärisera dessa mekanismer. Retinitis Pigmentosa (RP) är en ärftlig sjukdom där en genetisk defRetinitis pigmentosa (RP) is an inherited disorder and the leading cause of visual impairment in the working age population. It is caused by a number of different genetic mutations, all of which cause the rod photoreceptors to degenerate. As the rods become few in numbers, the cones will also begin to die, resulting in total blindness. Since the genetic defects leading to RP are numerous, it would
Objectives. To assess the optimal stroke prevention treatment for patients with atrial fibrillation (AF) and a low-medium risk (<=4%) of stroke. Design. A total of 668 patients with persistent or permanent AF, without an indication for full dose and with adequate rate control on sotalol, were randomized to warfarin 1.25 mg + aspirin 75 mg daily (W/A, 334 patients) or no anticoagulation (C, 334 pa
The process stability of water-in-oil-in-water (W/O/W) double emulsions stabilized with food-grade OSA modified quinoa starch granules was investigated. The effect of oils with differing melting points, as well as the effect of in situ partial gelatinization of the granules, on stability of emulsions was also investigated. The physical stability and release of a tracer (carmine) from the internal
Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimate
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet neuropeptide with potent insulinotropic action. The current study investigates PACAP expression in normal human and rat pancreatic islets, and whether it is altered in diabetic state. To that end, PACAP immunoreactivity was studied by immunofluorescence methods enhanced by the catalyzed reporter deposition (CARD) technique. Ins
To develop PDT beyond treatment of thin superficial tumours, to also be an efficient treatment alternative for deeply located and/or thick tumours, a system based on interstitial illumination using multiple fibres has been developed. Conditions that could benefit from such a treatment modality are for instance malignant brain tumours and tumours in the oral cavity. In interstitial PDT one needs to
To develop PDT beyond treatment of thin superficial tumors, to also be an efficient treatment alternative to deeply located and/or thick tumors, a system based on interstitial illumination using multiple fibers has been developed. Conditions that could benefit from such a treatment modality are for instance malignant brain tumors and tumors in the oral cavity. In interstitial PDT one needs to use
The aim of the thesis work is the further development of practical engine simulation tools based on Stochastic Reactor Models, SRMs. Novel and efficient implementations were made of a variety of SRMs adapted to different engine types. The models in question are the HCCI-SRM, the TwoZone SI-SRM and the DI-SRM. The specific models developed were incorporated into two different interfaces: DARS-ESSA,
Popular Abstract in Swedish Andelen vindkraft i elnätet har ständigt ökat under de senaste åren. I många länder utgör idag vindkraften en betydande del av den totala elproduktionen. Detta gäller även vid störningar då vindkraftverk – precis som vattenkraftverk och kärnkraftverk – måste fortsätta bidra till balansen mellan elproduktion och förbrukning. De nya reglerna för anslutning av vindkraft tiSynchronous generators have always been the dominant generation type in the grid. This fact affected both planning and operation of power systems. With the fast increase of wind power share in the grid in the last decade, the situation is changing. In some countries wind power represents already a consistent amount of the total generation. Wind turbines can be classified as non-synchronous generat
My article deals with the work of the St Joseph Sisters in the Nordic countries, particularly in Denmark and Sweden, from the sisters’ arrival in 1856 to the 1920:ies. These Catholic sisters belonged to a French congregation called "La Congregation des Sœurs de Saint-Joseph de Chambéry", which was founded at the beginning of the nineteenth century and whose motherhouse was in Chambéry in Savoy. Th
Viral vector-mediated gene transfer has emerged as a powerful means to target transgene expression in the central nervous system. Here we characterized the efficacy of serotypes 1 and 5 recombinant adeno-associated virus (rAAV) vectors encoding green fluorescent protein (GFP) after stereotaxic delivery to the neonatal rat and minipig striatum. The efficiency of GFP expression and the phenotype of
