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We present a comparative study of xanthorhodopsin, a proton pump with the carotenoid salinixanthin serving as an antenna, and the closely related bacteriorhodopsin. Upon excitation of retinal, xanthorhodopsin exhibits a wavy transient absorption pattern in the region between 470 and 540 nm. We interpret this signal as due to electrochromic effect of the transient electric field of excited retinal

In preclinical studies, p53 loss of function impacts chemotherapy response, but this has not been consistently validated clinically. We trained a TP53-loss phenocopy gene expression signature from pan-cancer clinical samples in the TCGA. In vitro, the TP53-loss phenocopy signature predicted chemotherapy response across cancer types. In a clinical dataset of 3003 breast cancer samples treated with

The speed at which the number of battery electric vehicles is growing is fueling debates and research on the criticality of battery materials. But rapid growth also enables fast uptake of new cathode chemistries, and electric vehicle batteries show considerable flexibility and material substitutability. Historical scaling of production is more dynamic than recognized in scenarios of future mineral

This is "an account of variable responses from Swedish municipalities in terms of both adaptation and mitigation measures. By looking at the relationships between national and municipal policies, Langlais examines the adaptation barriers and acknowledges the role of 'visionary individuals' in some municipalities for initiating local actions unders similar institutional and governance conditions. H

Nanostructured neural interfaces, comprising nanotubes or nanowires, have the potential to overcome the present hurdles of achieving stable communication with neuronal networks for long periods of time. This would have a strong impact on brain research. However, little information is available on the brain response to implanted high-aspect-ratio nanoparticles, which share morphological similaritie

Competition among phytoplankton for limiting resources may involve direct or indirect interactions. A direct interaction of competitors is the release of chemicals that inhibit other species, a process known as allelopathy. Here, we investigated the allelopathic effect of three toxic microalgae species (Alexandrium tamarense, Karenia mikimotoi and Chrysochromulina polylepis) on a natural populatio

Fluvial export of organic matter from the terrestrial catchment to the aquatic system is a large and increasing carbon flux. The successful reduction in sulfuric acid deposition since the 1980s has been shown to enhance the mobility of organic matter in the soil, with more terrestrially derived dissolved organic matter (DOM) reaching aquatic systems. Changes in soil acidity also affect the quality

Purpose: To investigate if plasma cytokine concentrations predict a beneficial response to corticosteroid treatment in septic shock patients. Methods: A cohort of septic shock patients in whom a panel of 39 cytokines had been measured at baseline (n = 363) was included. Patients who received corticosteroids were propensity score matched to non-corticosteroid-treated patients. An optimal threshold

Recurrent ear infection in children during pre-school years is an important public health problem. Common advice given to parents is to minimize exposure of susceptible children to crowding and air pollution. This study aimed at investigating what changes parents undertake to improve the health of an otitis-prone child. Parents of children with 5 events before age thirty months (index children; n

Some colours might have different connotations depending on people’s cultural backgrounds. When talking about evacuation, the colour employed for exit signs and flashing lights plays a significant role because it is responsible for conveying a message to the evacuees, either danger or safety. The aims of this study are to evaluate the influence of red and green emergency way-finding systems on the

Popular Abstract in Swedish Dekompressionssjuka (DCS) är ett tillstånd som kan uppkomma när man utsätts för en hastig sänkning av omgivningstrycket. Bakgrunden till tillståndet är att vävnadslagrad gas frisätts till blodbanan och där på olika sätt kan ge upphov till symptom från lätta hudbesvär till livshotande påverkan på det centrala nervsystemet. Vid atmosfärstryck är gasinnehållet i kroppens vReductions in ambient pressure liberates gas in various tissues and can result in decompression illness. In this thesis the patophysiological implications of a blood gas interface resulting from decompression was investigated with reference to the influence on biochemical mediators of inflammation. In a series of experiments, animals and human subjects have been exposed to hyperbaric trauma of dif

Heart period variability and heart rate were studied in 15 women and 15 men while they were viewing negatively (snakes/spiders), neutrally (scenic views), and positively (cats and kittens/puppies and dogs) valenced films. Time-frequency analyses of the heart period variability power spectrum in the high frequency region (0.12-0.4 Hz), reflecting respiratory sinus arrhythmia (RSA), were carried out

Some colors might have different connotations depending on people’s cultural backgrounds. When talking about evacuation, the color employed for exit signs and flashing lights plays a significant role because it is in charge of transmitting a message to the evacuees, either danger or safety. The aims of this study are to evaluate the influence of red and green emergency wayfinding systems on people

Background: Surgical trauma evokes a systemic cytokine response which is enhanced in patients with colorectal cancer. The aim of this study was to locate the origin of the systemic cytokine response to colorectal surgery. Methods: The concentrations of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) were analysed in systemic and mesenteric venous blood in 12 patients operated on

The article is a response to a lecture held by Sarah Coakley at Lund University 2009. In relation to Coakley's reflections on pain, the article addresses the question whether the Passion story still today, and not only in an ecclesial context, can serve as an incitement to a kind of self-examinating reflection. In other words, is it possible to retrieve through the Passion a narrative framework wh