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Background: Previous studies and own clinical observations of patients with systemic lupus erythematosus (SLE) suggest that SLE harbors distinct immunophenotypes. This heterogeneity might result in differences in response to treatment in different subgroups and obstruct clinical trials. Our aim was to understand how SLE subgroups may differ regarding underlying pathophysiology and characteristic b
BACKGROUND Heavy drinking and drug use is increasingly recognised as a problem in relation to holidays at nightlife resorts. However, studies conducted on the subject to date have relied on retrospective accounts of drinking, and little is known about the course of drinking, consequences and experiences during such holidays. METHODS A prospective study was carried out in Sunny Beach, Bulgaria, of
How do early-life conditions affect adult mortality? Research has yielded mixed evidence about the influence of infant and child mortality in birth cohorts on adult health and mortality. Studies rarely consider the specific role of mortality within the family. We estimated how individuals’ exposure to mortality as a child is related to their adult mortality risk between ages 18 and 85 in two histo
Mantle cell lymphoma (MCL) is an incurable disease with a highly variable clinical course. The prognosis after relapse is generally poor, and no standard of care exists. We investigated the postrelapse outcomes of 149 patients who were initially treated in the Nordic Lymphoma Group trials, MCL2 or MCL3, both representing intensive cytarabine-containing frontline regimens including autologous stem
Juice-pressing residues, among them blackcurrant pomace, are valuable materials for being upgraded in food products. Their excellent nutritional profiles in line with their functional properties allow a wide range of applications. The current study was performed to evaluate the overall liking of a pomace-enriched thin crispy-baked bread product in five European countries, and to obtain suggestions
Malignant melanoma is one of the most aggressive skin cancers with high potential of visceral dissemination. Since the information about melanoma genomics is mainly based on primary tumors and lymphatic or skin metastases, an autopsy-based visceral metastasis biobank was established. We used copy number variation arrays (N = 38 samples) to reveal organ specific alterations. Results were partly com
Optimisation of cultivation conditions in the industrial production of probiotics is crucial to reach a high-quality product with retained probiotic functionality. Flow cytometry-based descriptors of bacterial morphology may be used as markers to estimate physiological fitness during cultivation, and can be applied for online monitoring to avoid suboptimal growth. In the current study, the effects
Charge-density waves are responsible for symmetry-breaking displacements of atoms and concomitant changes in the electronic structure. Linear response theories, in particular density-functional perturbation theory, provide a way to study the effect of displacements on both the total energy and the electronic structure based on a single ab initio calculation. In downfolding approaches, the electron
The extremely small feature size and total sample volume of semiconductor nanowire materials has meant that advanced techniques have been required for even the most routine sample characterization since the structures were first reported. Electron microscopy has been the technique of choice for fast and reliable determination of nanowire morphology, structure, and composition since the earliest re
We consider the fundamental problem of assigning distinct labels to agents in the probabilistic model of population protocols. Our protocols operate under the assumption that the size n of the population is embedded in the transition function. Their efficiency is expressed in terms of the number of states utilized by agents, the size of the range from which the labels are drawn, and the expected n
Background: Repolarization prolongation can be the earliest electrophysiological change in ischemia, but its role in arrhythmogenesis is unclear. The aim of the present study was to evaluate the early ischemic action potential duration (APD) prolongation concerning its causes, expression in ECG and association with early ischemic ventricular fibrillation (phase 1A VF). Methods: Coronary occlusion
Background: The burden of Parkinson’s disease (PD) worsens with disease progression. However, the lack of objective and uniform disease classification challenges our understanding of the incremental burden in patients with advanced Parkinson’s disease (APD) and suboptimal medication control. The 5–2-1 criteria was proposed by clinical consensus to identify patients with advancing PD. Our objective
Rotavirus (RV) infection induces strong adaptive immunity. While protection from reinfection requires humoral immunity, initial clearance of infection depends on cytotoxic CD8 T cells. Type I classical dendritic cells (cDC1) excel at CD8 T cell induction through cross-presentation and are essential for optimal cytotoxicity towards RV. Upon sensing of infection-induced innate immune signals through
Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at the glia limitans, where it mediates water exchange across the blood-spinal cord and blood-brain barriers (BSCB/BBB), and controls cell volume, extracellular space volume, and astrocyte migration. Perivascular
Due to its range-dependent target response, frequency diverse array multiple-input multiple-output (FDA-MIMO) radar systems enable superior detection capabilities as compared with conventional phased-array radars. This paper proposes an incoherent detector for airborne FDA-MIMO radar to detect independent but possibly non-identically distributed fluctuating targets. For FDA-MIMO, variations in the
Human physiology is the study of how organisms, organ systems, and individual organs function under normal circumstances. As a consequence of its paramount importance to medicine, physiology has been studied since ancient times, but the models studied in this book follow the tradition of modern physiology pioneered by Claude Bernard in the mid 1800s.The focus of the book lies on how dynamical mech
To understand, predict and mitigate climate change, it is crucial to have long-term and standardised measurements of greenhouse gas concentrations in the atmosphere and their fluxes between atmosphere, land and oceans. The Integrated Carbon Observation System, is a distributed European Research Infrastructure which provides high-precision and highly standardised observations from more than 170 sta
Sveriges skogar påverkas av de hastiga globala klimatförändringarna. Inverkan av klimatförändringana syns redan med både ökad frekvens och kraftigare extremväder som stormar, värmeböljor, torka och skyfall. Ett tydligt exempel är den extrema torka som drabbade hela landet år 2018. Till följd av torkan har det bland annat skett en explosionsartad ökning av antalet granbarkborrar som angriper och döA changing climate is expected to lead to more extreme weather events, such as an increased frequency of droughts and forest fires. Changing forest conditions can offer benefits to species such as insects, including bark borers that thrive in warm conditions. Warmer temperatures also favor the acceleration of ozone (O3) production, which can cause stress on vegetation. Vegetation stress can have n
I denna uppsats har work-life balance och organisationskultur inom konsultbranschen hos nyexaminerade undersökts. Aspekterna har tidigare undersökts kopplat till konsultsektorn, men det har inte hittats forskning där både aspekter undersöks i relation till varandra för nyexaminerade. Huvudfrågeställningen för undersökningen lyder: Vilken betydelse har organisationskulturen för nyexaminerades uppleIn this essay, work-life balance and organizational culture within the consulting industry among recent graduates has been examined. Both aspects have been previously studied in the consulting sector, but previous research has not been found where both aspects are investigated in relation to each other and recent graduates. The main research question is: What significance does organizational cultu
