Filetype
Complement is a central homeotic system of mammals and represents the first defense line of innate immunity. The human complement system is aimed to maintain homeostasis by recognizing and removing damaged or modified self material, as well as infectious foreign microbes. However, pathogenic microbes also control and escape the host complement and immune attack. The increasing resistance of microb
Systemic glucose homeostasis is profoundly influenced by adipose cell function. Here we investigated GLUT4 dynamics in living adipose cells from human subjects with varying BMI and insulin sensitivity index (S-i) values. Cells were transfected with hemagglutinin (HA)-GLUT4-green fluorescent protein (GFP)/mCherry (red fluorescence), and were imaged live using total internal reflection fluorescence
Precise regulation of β-cell function is crucial for maintaining blood glucose homeostasis. Pax6 is an essential regulator of β-cell-specific factors like insulin and Glut2. Studies in the developing eye suggest that Pax6 interacts with Mitf to regulate pigment cell differentiation. Here, we show that Mitf, like Pax6, is expressed in all pancreatic endocrine cells during mouse postnatal developmen
Bioassay experiments were performed two times (with 2 years in between) in order to investigate if nitrogen (N, ammonium), phosphorus (P, phosphate) and carbon (C, glucose) additions would stimulate the growth of bacteria and phytoplankton differently in three different tropical aquatic environments. The water and their indigenous microbial communities were taken from a freshwater coastal lake (Ca
A biosensor, based on a redoxactive osmium polymer and sulfite oxidase on screen-printed electrodes, is presented here as a promising method for the detection of sulfite. A catalytic oxidative current was generated when a sample containing sulfite was pumped over the carbon screen-printed electrode modified with osmium redox polymer wired sulfite oxidase. A stationary value was reached after appro
Background: In this study we investigated (a) to what extent physicians have experience with performing a range of end-of-life decisions (ELDs), (b) if they have no experience with performing an ELD, would they be willing to do so under certain conditions and (c) which background characteristics are associated with having experience with/or being willing to make such ELDs. Methods: An anonymous qu
Application of Pulsed Electric Field (PEF) treatment on five fresh commodities was analysed for the changes in the metabolic and physiological effects on their shelf life. Treatment parameters were optimised in order to achieve uniform electroporation on the samples, which was analysed by Propidium Iodide staining for the leaf samples. The viability of electroporation of greenhouse (GH) rocket, co
This case study research aims to identify the enabling factors and challenges for developing a joint Standard Operating Procedure (SOP) for Disaster Response Preparedness between Jordan, Israel and Palestine. Twelve qualitative semi-structured interviews were conducted with experts either involved in the SOP project, the region and/or with extensive experience in developing cross-border SOPs. Thre
Syfte: Vårt syfte är att undersöka aktiekursutvecklingen hos statligt ägda bolag som privatiserats helt eller delvis genom en börsintroduktion eller en nyemission. Vidare syftar uppsatsen till att undersöka huruvida storleken av privatiseringen har någon betydelse för aktiekursens utveckling samt om privatiseringen kan användas som en investeringsstrategi. Metod: För att undersöka utvecklingen avPurpose: To examine the stock performance of formerly state owned enterprises that have been fully or partly sold to the market as a result of an IPO or SEO. The general purpose of this essay is to see if one can use privatizations as a investment strategy, and if the share size of the IPO or SEO can explanatory to the performance. Methodology: To be able to perform this study and fulfil the purp
Det saknas, så vitt vi vet, information om hur barn upplever svåra situationer i vardagen, och framförallt hur de upplever känslor som skam och skuld när de har en förälder med långvarig smärta. Dessutom finns det i Sverige inte någon insats inriktad på barnen under dessa förhållanden. Syftet med denna uppsats är att beskriva barnens upplevelse av skam och skuld av att leva med en långvarigt smärtThere is a lack, as far as we know, of information about how children experience difficult situations in everyday life and most importantly how they experience emotions such as shame and guilt when they have a parent with chronic pain. Moreover, in Sweden there is no effort focused on the children in these circumstances. The purpose of this study is to describe the children's experience of sha
With the evolving technology of mobile electronics and other forms of communication methods, an increasing demand of speech intelligibility is introduced. In a conference room for example, multiple microphones are placed directly in front of the speaker in order to pick up clean speech. However, several challenges still exist. For instance the distance between speaker and microphone will not be fi
In order to alleviate the financial burden on the healthcare sector as well as relax its employees’ workload, there is a need to introduce novel tools that automate some of the tasks that today are performed manually. Especially pathology poses a problem with few pathologists, demanding manual labour and unnecessary work on benign tissue. As a response, the DOGS project aims to develop a tool to a
AST och ADHD är idag en av de vanligaste diagnoserna bland barn i skolåldern i Sverige och tidigare forskning visar att de har svårt med bland annat kommunikation, emotionsreglering och sociala samspel. Denna studie syftar till att undersöka några av dessa problem i förhållande till empati. Begreppet empati har brutits ner i mindre beståndsdelar som består av affektiv empati, kognitiv empati och vASD and ADHD are some of the most common diagnoses among children in Swedish elementary schools. Research has shown that these groups have, among other, difficulties with communication, emotional regulation and social interaction. This study examines some of these difficulties in relation to empathy. The concept of empathy has been broken down into the smaller element’s affective empathy, cognitiv
The Swedish construction industry is subject to a high rate of occupational injuries, where overload factors are a significant cause. Through Human Activity Recognition, movement data can be collected and analyzed, enabling the identification of harmful movement patterns with the use of machine learning. This study aims to describe the environmental barriers and stakeholder attitudes towards a sma
This study investigated the applicability of mixture experimental design-based modeling approach to analyze insecticidal activity of thyme essential oils, particularly focusing on the synergistic interaction of their major constituents against Musca domestica. Chemical compositions of twelve commercially available thyme oils were analyzed using GC-MS, revealing their major constituents to be α-pin
Climate change and escalating human pressures erode the resilience of global forests, putting biodiversity, carbon storage, and societal well-being at risk. Fragmented, single-sector responses cannot keep pace with the speed or complexity of these threats. By synthesizing insights from resilience theory and global practices across ecological, social, and institutional dimensions, we propose 10 mut
The web is a constantly growing medium that presumably plays an increasing role in public library reference services. In order to provide high quality reference service the librarians need to be able to master this medium. Therefore it is interesting to get an understanding of how librarians actually use the web. The aim of this Master s thesis is to investigate what web search tools are used by p
Multiple myeloma (MM) is the second most common hematological malignancy, characterized by a clonal expansion of malignant plasma cells in bone marrow. Monoclonal gammopathy of undetermined significance (MGUS) is the premalignant condition of MM. The tumor microenvironment is thought to influence the progression from premalignant conditions. Myeloid-derived suppressor cells (MDSCs) are a heterogen
