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Background: Surgery and anesthesia have been linked to postoperative cognitive disturbance and increased risk of Alzheimer's disease. It is not clear by which mechanisms this increased risk for cognitive disease is mediated. Further, amyloid β production has been suggested to depend on the sleep-wake cycle and neuronal activity. The aim of the present study was to examine if cerebrospinal fluid (C
The delivery of immunomodulators directly into the tumor potentially harnesses the existing antigen, tumor-specific infiltrating lymphocytes, and antigen presenting cells. This can confer specificity and generate a potent systemic anti-tumor immune response with lower doses and less toxicity compared to systemic administration, in effect an in situ vaccine. Here, we test this concept using the nov
Background: The effectiveness of different procedures in routine surgical practice for hernia repair with respect to chronic postoperative pain and reoperation rates is not clear. Methods: This was prospective cohort study based on a unique combination of patient-reported outcomes and national registry data. Virtually all patients with a groin hernia repair in Sweden between September 2012 and Apr
Context: Anthropogenic and environmental changes are reshaping landscapes across the globe. In this context, understanding the patterns, drivers, and consequences of these changes is one of the central challenges of humankind. Purpose: We aim to test the possibilities of combining modern multidisciplinary approaches to reconstruct the land-cover and linking the changes in land-cover to socioeconom
Purpose Asthma is frequently reported in endurance athletes. The aim of the present study was to assess the long-term airway inflammatory response to endurance exercise in high-level athletes with and without asthma. Methods In a cross-sectional design, 20 asthmatic athletes (10 swimmers and 10 cross-country skiers), 19 athletes without asthma (10 swimmers and 9 cross-country skiers), and 24 healt
T cell-mediated immune responses are thought to play an important role in the pathogenesis of anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitides (AAV). CD4+ T cells can be divided into subsets depending on their expression of chemokine receptors. In this study, different CD4+ T cell populations in patients with AAV were analysed and compared to healthy blood donors as well as th
Aim: Hearing loss (as reflected by abnormal sound detection) is a frequently reported consequence of Type 1 diabetes mellitus. We sought to evaluate sound detection, auditory neural function and binaural processing ability in a group of school-aged participants with Type 1 diabetes and to assess their functional hearing and general communication ability. Methods: A range of electroacoustic, electr
Polyelectrolyte adsorption and polymer mediated interactions in different colloidal polymer systems have been studied in this work. Theoretical methods and experimental techniques are combined, in order to obtain more general reliable results, as well as a deep understanding of the molecular mechanisms that are responsible for the observed behaviors. Two different types of highly charged cationic
During the Proterozoic, several mafic dykes with variable trends and mineralogies intruded the Archaean basement of Southeast Greenland. Some of the younger ENE-trending dykes are interpreted to represent a prolongation of the Mesoproterozoic Gardar Province, and have been termed Timmiarmiit dykes. Extrapolations of their trends across the inland ice sheet coincide with the northernmost so-called
INTRODUCTION: Radiographers' engagement in research is important for the development of evidence-based practice in radiography; however, radiographers' interest in research has rarely been reported. This study sought to ascertain radiographers' opinions about radiography research and investigate their involvement in research activities in four Nordic countries.METHODS: This study was conducted in
For aquatic scientists mesocosm experiments are important tools for hypothesis testing as they offer a compromise between experimental control and realism. Here we present a new mesocosm infrastructure—SITES AquaNET—located in five lakes connected to field stations in Sweden that cover a ~760 km latitudinal gradient. SITES AquaNet overcomes major hindrances in aquatic experimental research through
Ambient temperature strongly determines the behaviour, physiology, and life history of all organisms. The technical assessment of organismal thermal niches in form of now so-called thermal performance curves (TPC) thus has a long tradition in biological research. Nevertheless, several traits do not display the idealized, intuitive dome-shaped TPC, and in practice assessments often do not cover the
PURPOSE: The chemokine receptor CXCR3 has been strongly related to inhibition of angiogenesis. The purpose of this study was to investigate the association between expression of CXCR3 on peripheral blood leukocytes and age-related wet macular degeneration. Furthermore, we measured the plasma concentration of chemokines CXCL9 to -11.METHODS: The study group consisted of patients with age-related ma
Spectral induced polarization (SIP) measurements have been demonstrated to correlate with important parame-ters in hydrogeological and environmental investigations. Although SIP measurements were often collected in thefrequency domain (FDIP), recent developments have demonstrated the capabilities to solve for the frequency-de-pendence of the complex conductivity through measurements collected in t
Benzodiazepine receptor binding heterogeneity evident from differential affinities of some ligands was compared with that suggested by differential interactions with γ-aminobutyric acid (GABA)/bicuculline and pyrazolopyridine/barbiturate receptor sites. The GABA receptor antagonist bicuculline only partially reverses pentobarbital enhancement of [3H] diazepam binding in rat brain membranes, while
Each year, massive numbers of insects fly across the continents at heights of hundreds of meters, carried by the wind, bringing both environmental benefits and serious economic and social costs. To investigate the insects' flight behavior and their response to winds, entomological radar has proved to be a particularly valuable tool; however, its observations of insect orientation are ambiguous wit
Background: The current understanding of mechanisms behind migraine pain has been greatly enhanced with the recent therapies targeting calcitonin gene-related peptide and its receptor. The clinical efficacy of calcitonin gene-related peptide-blocking drugs indicates that, at least in a considerable proportion of patients, calcitonin gene-related peptide is a key molecule in migraine pain. There ar
On October 7, 2023, Hamas launched an attack in Israel, killing approximately 1,200 Israelis and taking hundreds hostage. In response, the Israeli government initiated a large-scale military operation in Gaza. As of March 2025, the strip is left in ruins with more than 50,000 Palestinians estimated to have been killed by Israeli warfare. The war has resulted in a fragmented and deeply divided inte
The topic of this study is the phosphorylation dependent interaction between aquaporin 2 (AQP2) and the FERM domain of ezrin. AQP2 is an important water channel for finetuning the water content of the urine based on the needs of the body. The main way of regulating how much water is reabsorbed is by regulating the amount of AQP2 present in the apical membrane. This regulation is controlled throug
