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Aim To understand the role and significance of the reindeer, Rangifer tarandus (Linnaeus, 1758), as a specific indicator in terms of late Quaternary biogeography and to determine the effects of global climate change on its range and local extinction dynamics at the end of the Ice Age. Location Late Pleistocene/early Holocene range of reindeer over all of central and western Europe, including south
Organ culture is an in vitro method for investigating cellular mechanisms involved in upregulation of vasocontractile G-protein coupled receptors. We hypothesize that mitogen-activated-protein kinase (MEK) and/or extracellular-signal-regulated kinase (ERK) specific inhibitors will attenuate the G-protein coupled receptor expression following organ culture. Rat cerebral arteries were incubated 48 h
Background & Aims: The robust association between non-alcoholic fatty liver disease (NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated. The aim of this study was to investigate the effect of the PNPLA3 I148M mutation on: (1) hepatic secretion of very low density lipoproteins (VLDL) in humans; and (2) secretion of apolipoprotein B (apoB) from McA-RH 7777 cells
AimTo project the potential European distribution of seven broad habitat categories (needle-leaved, broad-leaved, mixed and mediterranean forest, urban, grassland and cropland) in order to assess effects of land use, climate change and increase in CO2 on predicted habitat changes up to the year 2050. LocationEurope. MethodWe modelled the response of European vegetation to changes in land use, clim
Popular Abstract in Swedish Kroniska bensår utgör en av våra folksjukdomar, där 1% av befolkningen någon gång drabbas. Uppkomsten av sår kan ha en mängd olika orsaker. Den största gruppen är venösa sår, dvs sådana som orsakats av vensjukdom. Behandling av sår har i långa tider betraktats som komplicerad, då såren ofta varit svårläkta och återkommit efter läkning. För den enskilde patienten innebärWound management in primary and community care was investigated throughout a period of 12 years within a well-defined population in one county in Southern Sweden. The estimated prevalence of chronic leg and foot ulcers was 0.19% in 1998 and the mean prevalence was 0.20% during the years 1994-1998. Venous ulcers were the most common (38%) and 7% of the nurses’ workload was devoted to ulcer care. Du
Popular Abstract in Swedish Råttans urinblåsa har studerats ur olika aspekter, sedan antingen ett standardiserat avflödeshinder åstadkommits eller hälften av urinblåsans nervförsörjning avlägsnats. Avflödeshindret har åstadkommits genom att en silkestråd knutits runtom urinröret så att det försnävats. Genom att en knappt mm-vid metallstav knutits om samtidigt och sedan avlägsnats, har graden av avMedian micturition volume decreased early after partial outlet obstruction, 24 hrs total obstruction and hemidenervation. Degeneration release of transmitter may explain this, assuming that bladder wall distension causes nerve degeneration. Micturition pressure decreased simultaneously in the partially denervated and 24 hrs obstructed groups, probably due to the reduced number of functionally inta
Popular Abstract in Swedish Neuoroblastom är en av de tumörformer som oftast drabbar små barn. Eftersom tumörer lyckligtvis är relativt ovanliga hos barn drabbas inte fler än i genomsnitt 14 barn årligen av neuroblastom i Sverige. Tyvärr finns dock, trots den effektiva behandling som kunnat arbetas fram för många andra barncancerformer, idag ingen verksam behandling att tillgå för så många som hälNeuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. Expression of trkA and trkC is linked to f
Popular Abstract in Swedish Slemhinnan i de övre luftvägarna utgör ett första skydd mot luftburna hot såsom bakterier, virus samt partiklar som kan förorsaka allergiska reaktioner. Kroppen reagerar på ett likartat sätt oavsett ursprunget till slemhinneskadan. Den reagerar med en aktivering av de inflammatoriska cellerna. Det finns ett välutvecklat samarbete mellan dessa celltyper. De har förmåga aIn this study we demonstrated the production of SLPI (Secretory Leukocyte Protease Inhibitor) in serous glands in the nasal mucosa. We have shown that the pattern of the expression of mRNA corresponds to the encoded protein. The encoded protein was detected by immunohistochemical methods and mRNA was discovered by in situ hybridisation. Nasal mucosa from 11 test subjects without atopic disposition
Popular Abstract in Swedish Hur man undviker att bli trakasserad på flicksländornas vis Tidigare forskningsresultat har visat att hos honor i de flesta djurarter begränsas fortplantningkapacitet av hur mycket tid och energi de kan lägga på sina avkommor. Hos hanar, å andra sidan, begränsas fortplantningskapacitet av hur många honor de kan para sig med. Då kan man dra slutsatsen att hanar ska försThis study has involved investigation of number of populations of the damselfly Ischnura elegans over several years, looking at frequency changes over time, morphological differences between the sexes and the morphs, differences in growth rate and development time, differences in fecundity between the morphs, and genetic differentiation between populations. I. elegans is a small annual damselfly w
Popular Abstract in Swedish Händerna utsätts dagligen för olika typer av faror. Handskador av varierande omfattning är därför inte ovanliga. Dessa kan drabba både barn och vuxna, såväl under fritiden som i arbetslivet. Panoramat av handskador har förändrats. För omkring 40 år sedan var handskador vanligt förekommande på arbetsplatsen, men har sedan dess minskat så att de för 20 år sedan utgjorde uHand injuries have a profound impact not only on the patient’s activity of daily living and during leisure time but also on working capability. Such injuries may therefore also generate substantial costs for society in terms of sick-leave and treatment. In the present thesis, the panorama, costs (within the health-care system, due to lost production and total costs), outcome and health status of p
Popular Abstract in Swedish Sedering vid respiratorbehandling inom intensivvård ? praxis av sedering och patienters minnen, påfrestande upplevelser och psykologiska problem Akut svårt sjuka patienter i behov av respiratorbehandling på en intensivvårds-avdelning (IVA) utsätts för akut stress och diverse obehag från sjukdomen och/eller skadan, behandlingen, andningstuben och IVA-miljön. MinnesstörnThe overall aim of this thesis was to describe and determine intensive care sedation in adult mechanically ventilated patients with the emphasis on patients? memory, stressful experiences and psychological distress. The results are based on a nationwide postal survey (Paper I) including 89 Swedish intensive care units (ICUs) followed by a prospective cohort study (Papers II?IV) conducted over 18 m
Reduced heart rate variability (HRV) is associated with poor outcome in patients with heart failure (HF). However, the data on predictive value of RR variability during atrial fibrillation (AF) are limited. Therefore, the aim of this study was to evaluate the association between ventricular response characteristics and long-term clinical outcome in the population of ambulatory patients with mild-t
Gas chromatography/mass spectrometry-based metabolomics was applied to investigate dynamic changes in the plasma metabolome upon an oral glucose tolerance test (OGTT). The OGTT is a frequently used diagnostic test of glucose homeostasis and diabetes. Diabetes is diagnosed either when glucose levels a parts per thousand yen7.0 mM in the fasting state or a parts per thousand yen11.0 mM at 2 h after
Objective: The vagina makes a major contribution to the normal female sexual response cycle. An increase in vaginal blood flow is considered a key event in the mechanism of sexual arousal. Recent research has focused mainly on the cyclic GMP pathway and phosphodiesterase type 5 (PDE5, cyclic GMP specific PDE) in the control of vaginal vascular smooth muscle, whereas only little is known on the rol
Soil biodiversity plays a key role in regulating the processes that underpin the delivery of ecosystem goods and services in terrestrial ecosystems. Agricultural intensification is known to change the diversity of individual groups of soil biota, but less is known about how intensification affects biodiversity of the soil food web as a whole, and whether or not these effects may be generalized acr
Lipophilic statins purportedly exert anti-tumoral effects on breast cancer by decreasing proliferation and increasing apoptosis. HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway, is the target of statins. However, data on statin-induced effects on HMGCR activity in cancer are limited. Thus, this pre-operative study investigated statin-induced effects on tumor prolifera
This paper is based on the findings of a research work by Abukhader and Jönson (2004a), who discuss the possibilities and limitations of the ties of postponement strategy in food supply chains. They identified the cases/examples (i.e. company cases) of application of postponement across the various categories of foods: frozen, chilled/fresh and long shelf life. The food industry nowadays is in nee
AIM: To assess how drinking patterns and delinquency are associated with self-reported experiences of alcohol-related violence in an adolescent population. POPULATION AND RESEARCH DESIGN: Cross-sectional data were acquired from the Scania drug use survey 2005, consisting of 3847 students in 9th grade. Abstainers were omitted and 1873 responses analyzed, with binary and multi-variable logistic regr
Migratory animals are affected by various factors during their journeys, and the study of animal movement by radars has been instrumental in revealing key influences of the environment on flying migrants. Radars enable the simultaneous tracking of many individuals of almost all sizes within the radar range during day and night, and under low visibility conditions. We review how atmospheric conditi
Semiconductor nanowire (NW) technology has emerged as a key facilitator of novel optoelectronics e.g. solar cells, photodetectors and LEDs. The functional wavelength range of current NW-based photodetectors is typically limited to the visible/near-infrared region. In this work, we present the first ever reported electrical and optical characteristics of longwavelength IR photodetectors based on la
