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Parkinson's disease (PD) is a complex neurodegenerative disease, characterized by a progressive lossof dopaminergic neurons (DN) in the substantia nigra (SN) that innervate the striatum (ST) and pathologicalaccumulation of alpha-synuclein (αsyn) protein in aggregates called Lewy bodies (LB) and Lewy neurites(LN). As a complex disease, PD presents a genetically heterogeneous origin. Mutations in si
Spatial orientation is a prerequisite for most behaviors. In insects, the underlying neural computations take place in the central complex (CX), the brain’s navigational center. In this region different streams of sensory information converge to enable context-dependent navigational decisions. Accordingly, a variety of CX input neurons deliver information about different navigation-relevant cues.
Objective Behaviour therapy (BT) for Tourette's disorder (TD) and persistent (chronic) motor or vocal tic disorder (PTD) is rarely available. We evaluated the feasibility of adapting two existing BT protocols for TD/PTD (habit reversal training (HRT) and exposure and response prevention (ERP)) into a therapist-guided and parent-guided online self-help format. Design A pilot, single-blind, parallel
Normal birth is a eustress reaction, a beneficial hedonic stress with extremely high catecholamines that protects us from intrauterine hypoxia and assists in the rapid shift to extrauterine life. Occasionally the cellular O2 requirement becomes critical and an O2 deficit in blood (hypoxemia) may evolve to a tissue deficit (hypoxia) and finally a risk of organ damage (asphyxia). An increase in H+ c
Background and aims: There is convincing evidence that adaptive immune responses affect the development of atherosclerosis and thrombosis and several autoimmune diseases are associated with increased cardiovascular risk. However, our understanding of the underlying mechanisms remains limited. We investigated how biomarkers reflecting four aspects of autoimmunity: apoptosis, inflammation, tissue de
Schemes to promote sustainable forest management have increasingly focused on addressing widespread informalities in timber production, based on the presumed links between formalisation, the maintenance of forest cover and local welfare. This trend is typified by the EU Forest Law Enforcement, Governance and Trade (FLEGT) initiative and associated Voluntary Partnership Agreements (VPA) aimed at er
TMA20 (MCT-1), TMA22 (DENR) and TMA64 (eIF2D) are eukaryotic translation factors involved in ribosome recycling and re-initiation. They operate with P-site bound tRNA in post-termination or (re-)initiation translation complexes, thus participating in the removal of 40S ribosomal subunit from mRNA stop codons after termination and controlling translation re-initiation on mRNAs with upstream open re
Activation of the kynurenine pathway (KP) has been reported in patients with pulmonary arterial hypertension (PAH) undergoing PAH therapy. We aimed to determine KP-metabolism in treatment-naïve PAH patients, investigate its prognostic values, evaluate the effect of PAH therapy on KP-metabolites and identify cytokines responsible for altered KP-metabolism. KP-metabolite levels were determined in pl
Annual rates of adrenalectomy have doubled in the last 20 years as a consequence of increased detection of adrenal incidentalomas, improved biochemical diagnosis, genetic screening, and minimally invasive surgical techniques. Most adrenal incidentalomas are benign non-functional adrenocortical adenomas. Functional adrenal tumours are associated with high morbidity if left untreated, and this may b
The formation path from small poorly absorbing incipient soot to larger fractal-like strongly absorbing black soot is extensive, and along this path the optical and physicochemical properties of the soot evolve. Soot emitted into the atmosphere may originate from some stage of this process, which will result in a wide spectrum of carbonaceous aerosols in the atmosphere which may interact with the
Immune cell-derived cytotoxic pathways have been implicated in antitumor immune responses. The goal of this study is to characterize how these cytotoxic pathways influence ovarian cancer development. We have utilized the TgMISIIR-TAg transgenic mouse model which expresses the transforming SV40 TAg in the ovary, leading to spontaneous development of ovarian tumors that closely mimic human epithelia
Aims. The Landé g-factor is an important parameter in astrophysical spectropolarimetry, used to characterize the response of a line to a given value of the magnetic field. The purpose of this paper is to present accurate Landé g-factors for states in B II, C I-IV, Al I-II, Si I-IV, P II, S II, Cl III, Ar IV, Ca I, Ti II, Zr III, and Sn II. Methods. The multiconfiguration Dirac-Hartree-Fock and rel
Uppsatsen undersöker hur Dublinförordningen förhåller sig till Europakonventionen, med fokus på artikel 8 om rätten till respekt för privatliv, familjeliv, hem och korrespondens. Dublinförordningen är det instrument i EU:s gemensamma asylsystem som bestämmer vilken medlemsstat som ska ansvara för att pröva en inkommen asylansökan. På senare år har mycket kritik riktats mot Dublinförordningen p.g.aThe essay examines how the Dublin Regulation relates to the European Convention on human rights, focusing on Article 8 on the right to respect for privacy, family life, home and correspondence. The Dublin Regulation is the instrument of the EU's Common Asylum System, which determines which Member State will be responsible for examining an asylum application. In recent years, much criticism has
Ett av Sveriges klimat- och energipolitiska mål avser effektivare energianvändning. Ett sätt att uppnå målet är genom kravställning på energihushållning vid renovering av byggnader. I de fall då det med hänsyn till byggnadens kultur- och arkitektoniska värde inte går att tillämpa beprövade metoder får andra alternativa metoder sökas. En sådan annan alternativ metod är en dubbelskalfasad och innebäOne of Sweden's political objective is to increase energy efficiency. One way to achieve the objective is by making demands on the use of energy after a building has been renovated. Regarding the building's cultural and architectural values there are cases where it is not possible to apply proven methods to meet the demands, and other alternative methods must be sought. Such an alternative
The electricity sector is in the beginning of a large shift from centralized dispatchable production to distributed variable production. With this necessary change, new challenges arise. One crucial challenge is related to upholding the system balance in the power grid. In this master thesis, a Battery Energy Storage System (BESS) has been implemented in an HVDC-system with large amounts of Wind P
The interstellar medium of both local and distant disc galaxies is observed to be supersonically turbulent and the turbulent motion of the gas is thought to be important for galaxy formation and evolution, particularly as a key ingredient for star formation. Consequently, this generates a striking relation between the star formation rate (SFR) and gas velocity dispersion ($\sigma_{\rm g}$; a measu
Flyktingar löper signifikant högre risk för att utveckla psykisk ohälsa, däribland posttraumatiskt stressyndrom (PTSD). Det finns en stor evidensbas som visar att traumafokuserade psykologiska behandlingar för PTSD är effektiva. Majoriteten av denna forskning inkluderar dock inte flyktingar, vilket innebär att mindre är känt om responsen för behandling av PTSD hos flyktingar. Den aktuella översiktRefugees are at significantly increased risk of mental health difficulties, including Post-Traumatic Stress Disorder (PTSD). There is a large evidence base showing that trauma-focused psychological treatments for PTSD are effective. However, the majority of trials do not include refugees and less is known about response to PTSD treatments in refugees. The present scoping review explores the curren
Employee engagement and employer branding are highly relevant in today's labor market, where employers no longer hold all the cards, but the employees assert their demands as well. Furthermore, there is a scarcity in research exploring the interaction between employee engagement and employer branding. This study investigates through a case study how employee engagement and employer branding in
As carbon dioxide emissions increase along with the global average temperature, sustainable development is becoming more and more important in all sectors, and it is essential to act toward the reduction of emissions to counteract these dire consequences. Companies are expected to operate sustainably and responsibly with a minimized negative environmental impact alongside accelerating their digita
Sustainability, population dynamics and health issues are some of the greater challenges the global society faces today. Meat consumption has emerged as one of the reasons behind the cause and effect of these challenges. There is a growing consensus amongst researchers, industry stakeholders and decision-makers that there is a need to transition into more sustainable alternatives to meat. As a res
