Search results

The aim of this work was to characterize the effect of experimental diabetes on neurotransmission in rat vagina. Female Sprague-Dawley rats were divided into two groups: non-diabetic controls (NDM, n=38) and diabetics (DM, n=38). DM was produced by intraperitoneal injection of streptozotocin. Eight weeks later the animals were killed, the distal part of the vagina was removed, and smooth muscle st

Popular Abstract in Swedish Råttans urinblåsa har studerats ur olika aspekter, sedan antingen ett standardiserat avflödeshinder åstadkommits eller hälften av urinblåsans nervförsörjning avlägsnats. Avflödeshindret har åstadkommits genom att en silkestråd knutits runtom urinröret så att det försnävats. Genom att en knappt mm-vid metallstav knutits om samtidigt och sedan avlägsnats, har graden av avMedian micturition volume decreased early after partial outlet obstruction, 24 hrs total obstruction and hemidenervation. Degeneration release of transmitter may explain this, assuming that bladder wall distension causes nerve degeneration. Micturition pressure decreased simultaneously in the partially denervated and 24 hrs obstructed groups, probably due to the reduced number of functionally inta

Popular Abstract in Swedish Neuoroblastom är en av de tumörformer som oftast drabbar små barn. Eftersom tumörer lyckligtvis är relativt ovanliga hos barn drabbas inte fler än i genomsnitt 14 barn årligen av neuroblastom i Sverige. Tyvärr finns dock, trots den effektiva behandling som kunnat arbetas fram för många andra barncancerformer, idag ingen verksam behandling att tillgå för så många som hälNeuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. Expression of trkA and trkC is linked to f

Popular Abstract in Swedish Slemhinnan i de övre luftvägarna utgör ett första skydd mot luftburna hot såsom bakterier, virus samt partiklar som kan förorsaka allergiska reaktioner. Kroppen reagerar på ett likartat sätt oavsett ursprunget till slemhinneskadan. Den reagerar med en aktivering av de inflammatoriska cellerna. Det finns ett välutvecklat samarbete mellan dessa celltyper. De har förmåga aIn this study we demonstrated the production of SLPI (Secretory Leukocyte Protease Inhibitor) in serous glands in the nasal mucosa. We have shown that the pattern of the expression of mRNA corresponds to the encoded protein. The encoded protein was detected by immunohistochemical methods and mRNA was discovered by in situ hybridisation. Nasal mucosa from 11 test subjects without atopic disposition

Popular Abstract in Swedish Hur man undviker att bli trakasserad på flicksländornas vis Tidigare forskningsresultat har visat att hos honor i de flesta djurarter begränsas fortplantningkapacitet av hur mycket tid och energi de kan lägga på sina avkommor. Hos hanar, å andra sidan, begränsas fortplantningskapacitet av hur många honor de kan para sig med. Då kan man dra slutsatsen att hanar ska försThis study has involved investigation of number of populations of the damselfly Ischnura elegans over several years, looking at frequency changes over time, morphological differences between the sexes and the morphs, differences in growth rate and development time, differences in fecundity between the morphs, and genetic differentiation between populations. I. elegans is a small annual damselfly w

Although deaf children depend upon sight for communication, retinitis pigmentosa is present in 6 per cent of those with a profound hearing deficit. Usher syndrome type 1 (USH-1) is an autosomal recessive disease characterised by profound hearing impairment, absent vestibular function, and progressive loss of vision due to retinitis pigmentosa. Owing to the severe handicap of the combined disorders

I den här avhandlingen studeras styrning av välfärdssamverkan, med focus på betydelsen av kunskap i styrning. I offentlig verksamhet – och i välfärd i synnerhet – är samverkan mellan myndigheter, kommunala förvaltningar och välfärdsprofessionella ett återkommande sätt att hantera olika problem som de traditionella offentliga institutionerna anses oförmögna att lösa. Genom att studera ett specifiktThis dissertation analyses how welfare collaboration is governed, focusing on the role of knowledge in government. In the public sector – and in welfare especially – collaboration between agencies, municipal departments and welfare professions is a recurring response to various problems where the traditional public-sector institutions are considered inapt to provide solutions. By studying a specif

Background and aims: There is convincing evidence that adaptive immune responses affect the development of atherosclerosis and thrombosis and several autoimmune diseases are associated with increased cardiovascular risk. However, our understanding of the underlying mechanisms remains limited. We investigated how biomarkers reflecting four aspects of autoimmunity: apoptosis, inflammation, tissue de

BACKGROUND: Small molecule inhibitors of phosphatidylinositol-3 kinase (PI3K) have been developed as molecular therapy for cancer, but their efficacy in the clinic is modest, hampered by resistance mechanisms.METHODS: We studied the effect of PI3K therapy in patient-derived tumor organotypic cultures (from five patient samples), three glioblastoma (GBM) tumor cell lines, and an intracranial model

Pain, use of painkillers and alcohol are highly prevalent in the general population. Aims of the study were to describe differences in pain, alcohol consumption and use of painkillers among two 60 year old birth cohorts stratified by gender. Participants were recruited from the Skåne centre of The Swedish National study on Aging and Care, a multicentre, prospective, longitudinal study. The sample

Migratory animals are affected by various factors during their journeys, and the study of animal movement by radars has been instrumental in revealing key influences of the environment on flying migrants. Radars enable the simultaneous tracking of many individuals of almost all sizes within the radar range during day and night, and under low visibility conditions. We review how atmospheric conditi

AIM: To assess how drinking patterns and delinquency are associated with self-reported experiences of alcohol-related violence in an adolescent population. POPULATION AND RESEARCH DESIGN: Cross-sectional data were acquired from the Scania drug use survey 2005, consisting of 3847 students in 9th grade. Abstainers were omitted and 1873 responses analyzed, with binary and multi-variable logistic regr

An important role for WNT-5A is implicated in a variety of tumors, including breast carcinoma. We previously showed that WNT-5A signaling inhibits migration and metastasis of breast cancer cells, and that patients with primary breast cancer in which WNT-5A was expressed have a better prognosis. Despite the fact that RhoGTPase Cdc42 is commonly associated with increased cell migration, we here show

Aims: To establish a cardiac cell culture model for simulated ischemia and reperfusion and in this model investigate the impact of simulated ischemia and reperfusion on expression of the calcium handling proteins FKBP12 and FKBP12.6, and intracellular calcium dynamics. Methods: HL-1 cell cultures were exposed to normoxia (as control), hypoxia, simulated ischemia (HEDA) or HEDA + reactive oxygen sp

BACKGROUND: : Atherosclerosis is considered to be an inflammatory disease. Infections are a significant cause of inflammation. Acute infections might precipitate acute coronary syndromes (ACS) whereas chronic infections might be stimuli for the development of atherosclerosis. METHODS: : Coronary angiograms were done on 211 of 335 patients with ACS and the percentage of coronary obstruction was det

Objective The primary objective of this study was to assess the impact of atomoxetine in combination with psychoeducation, compared with placebo and psychoeducation, on health-related quality of life (HRQL) in Swedish stimulant-naive pediatric patients with attention deficit/hyperactivity disorder (ADHD). HRQL results will be presented elsewhere. Here, psychoeducation as well as efficacy and safet

Bones are able to adapt their local density when exposed to mechanical loading. Such growth processes result in densification of the bone in regions of high loading levels and in resorption of the material in regions of low loading levels. This evolution and optimisation process generates heterogeneous distributions of bone density accompanied by pronounced anisotropic mechanical properties. While

Cigarette smoke exposure increases the risk of stroke. However, the underlying molecular mechanisms are poorly understood. Endothelin system plays key roles in the pathogenesis of stroke. The present study was designed to examine if lipid-soluble (dimethyl sulfoxide-soluble) cigarette smoke particles (DSP) induces upregulation of contractile endothelin type B (ETB) receptors in rat cerebral arteri

Background Interleukin (IL)-15 levels are increased in serum, synovium and bone marrow of patients with rheumatoid arthritis (RA). IL-15 influences both the innate and the adaptive immune response; its major role is activation and proliferation of T cells. There are also emerging data that IL-15 affects osteoclastogenesis. The authors investigated the association of genetic variants in IL15 with t