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Political institutions are keen to use the best available scientific knowledge in decision-making. For environmental policy, relevant scientific evidence can be complex and extensive, so expert judgment is frequently relied upon, without clear links to the evidence itself. We propose a new transparent process for incorporating research evidence into policy decisions, involving independent synopsis
The purpose of this study was to identify trends in modern single family homes that might have an impact on residential fires. The study compared older homes with modern ones, starting from the 1960s and on to the 2000s. The fire service development during the same period was analyzed to see how their capacity to handle these fires have changed. The conclusions of this study were that many factors
This thesis compares how Sweden and Finland’s contrasting exchange rate regimes shaped their export sector performance during the 2008 Global Financial Crisis. While both are small, open Nordic economies, Sweden maintained a floating currency and independent monetary policy, whereas Finland adopted the euro and ceded monetary control to the European Central Bank. The study evaluates export revenue
The interactions between a stream and nearby shallow aquifers were investigated in a mountain basin being polluted by mercury released during mining in central Nicaragua. Hourly data series of water levels and temperatures were analysed using cross-correlation. Resistivity imaging was used to map the subsurface and to complement the hydrological data interpretation. The results show the complex hy
Enzymes that affect glycoproteins of the human immune system, and thereby modulate defense responses, are abundant among bacterial pathogens. Two endoglycosidases from the human pathogen Streptococcus pyogenes, EndoS and EndoS2, have recently been shown to hydrolyze N-linked glycans of human IgG. However, detailed characterization and comparison of the hydrolyzing activities have not been performe
This article deals with the possible existence of deliberate fertility control before the fertility transition. The timing of the fertility response to economic stress, as measured by fluctuations in grain prices, is used as a measure of deliberate, but non-parity specific, control. Birth histories from six German villages (1766–1863), including information on occupation of the husband, are used t
Technological innovation is still a challenge for SMEs in emerging countries, mainly due to the lack of financial, structural, capital, and proper managerial resources. Covid-19 presented a scenario that increased difficulties for companies, especially of this kind, and at the same time presented a necessity-driven impulse to look for innovative solutions. This study aimed to analyze the drivers o
Vi utvärderar behandlingsmetoder för svårbehandlade psykiatriska tillstånd, med målet att förbättra behandlingsresultat och klinisk praxis. KetECT-studien, som jämförde ketamin med elektrokonvulsiv terapi (ECT) vid unipolär depression, har bidragit till att ketamin nu är ett alternativ för vissa patienter. Blodprover och kognitiva data från KetECT kommer att analyseras för att identifiera biomarköWe evaluate treatment methods for refractory psychiatric conditions, aiming to improve outcomes and clinical practice. The KetECT study, which compared ketamine with electroconvulsive therapy (ECT) in unipolar depression, has led to ketamine being considered an alternative for certain patients. Blood samples and cognitive data from KetECT will be analyzed to identify biomarkers that can predict tr
The potential of a nucleic acid-based optical bioprobe for environmental measurements and drug monitoring is described. The sensor employs the long-wavelength intercalating fluorophore TO-PRO-3 (TP3). Compounds that interact with the TP3-DNA complex are indirectly detected by a decrease in the fluorescence intensity. We found that the configuration and length of the DNA dramatically affected the i
Recent advances in molecular and cell biology may allow for the development of novel strategies for the treatment and cure of type 1 diabetes. In particular, it is now possible to envisage restoration of insulin secretion by gene or cell-replacement therapy. The β-cell is, however, remarkably sophisticated, and many of the features of this highly differentiated secretory cell will have to be faith
Molecular evolution approaches to developing molecules with characteristics particularly suited for specific applications have become important tools in biomedicine and biotechnology. Not only is it possible to identify molecules with specificities that cannot easily be obtained by other means, but it is also possible to fine-tune in an efficient manner the properties for, in principle, any specif
BackgroundDeviating vital signs have been known to precede Serious Adverse Events (SAEs) like In-Hospital Cardiac Arrest (IHCA), unplanned Intensive Care Unit (ICU) admission or unexpected death for more than a decade but still the recognition of these deteriorating patients is poor.The British National Early Warning Score (NEWS) is a ‘‘track and trigger’’ scale designed to assess in-hospital patiBackgroundDeviating vital signs have been known to precede Serious Adverse Events (SAEs) like In-Hospital Cardiac Arrest (IHCA), unplanned Intensive Care Unit (ICU) admission or unexpected death for more than a decade but still the recognition of these deteriorating patients is poor.The British National Early Warning Score (NEWS) is a ‘‘track and trigger’’ scale designed to assess in-hospital pati
Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with unfavourable prognosis for patients with advanced stages of the disease. Refractory disease and advanced-stage disease require systemic therapy. We report on a rare case of an atypical predominantly CD8 + folliculotropic MF, a subtype of MF with poorer prognosis, in a 59-year-old woman. She was initially diagnosed with MF restric
