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SLAMF6 is an immunoregulatory molecule studied in cancer research as a possible target for immunotherapy in acute myeloid leukaemia (AML). The absence of SLAMF6 has been shown to elevate T cell activation and improve anti-tumour responses (1). The regulatory mechanism of SLAMF6 is not fully understood. The aim of this thesis was to investigate the effect of SLAMF6 on T cell signalling using fluore
Switzerland operates one of the strictest regimes regulating posted work in Europe, going beyond what EU law requires in several aspects. Based on Switzerland's interpretation of the Posted Work Directive, it introduced the so-called Flanking Measures, which regulates posted work in Switzerland, and despite posing burdensome administrative costs, limited market access, and potentially high fin
Popular Abstract in Swedish Förekomsten av sjukdomar inom det sk metabola syndromet (typ 2 diabetes, insulinresistans, övervikt, högt blodtryck och hjärt-kärlsjukdomar) ökar kraftigt i västvärlden. En viktig faktor för utvecklandet av detta syndrom är en försämrad insulinkänslighet. När kroppen utsätts för kontinuerligt höga insulinnivåer försämras känsligheten för detta hormon vilket resulterar iThe metabolic syndrome (type 2 diabetes, obesity, hypertension, atherosclerotic cardiovascular disease, dyslipidaemia, and hyperinsulinaemia), is increasing in prevalence world-wide. The progression of this syndrome proceeds through a step-wise deterioration of metabolic events where deterioration of insulin sensitivity appears to have a key role in a ?vicious circle? of hyperinsulinaemia/hypergly
Curious about tourism and sustainability, Lisa chose Lund University for its academic depth and international outlook. With inspiring professors, field trips, and a close-knit campus life in Helsingborg, the programme has given her both perspective and practical insight.
Alzheimer's disease (AD) is a neurodegenerative disease which is manifested by a progressive and irreversible decline of cognition, memory loss, a shortened attention span, and changes in personality. Aging and genetic pre-dispositions, particularly the presence of a specific form of apolipoprotein E (APOE), are main risk factors of sporadic AD; however, a large body of evidence has shown that mul
Morarella catarrhalis immunoglobulin D-binding protein (MID) is a complex antigen with unique immunoglobulin D (IgD)-binding, adhesion, and hernagglutination properties. Previous studies have shown that antibodies raised against MID764-111 in rabbits inhibited M. catarrhalis adhesion to human alveolar epithelial cells, and immunization with MID764-913 resulted in an increased pulmonary clearance i
Receptor tyrosine kinase (RTK) c-Kit signalling is crucial for the proliferation, survival and differentiation of haematopoietic stem cells (HSCs). To further understand the mechanisms underlying these events we explored how the downstream mediators interact. The present study investigated the function of conventional protein kinase Cs (c-PKC) in c-Kit mediated signalling pathways in HSC-like cell
Abstract is not available
RDW is a new and easily available risk marker for adverse cardiovascular outcomes and we agree that this may encourage a wider use in clinical practice. As pointed out by Balta et al [2], the underlying causal links are unclear. The causal links could hypothetically involve some of the factors mentioned by Balta et al [2], but also properties of the red cells per se. This article is protected by c
Congenic BioBreeding (BB) rats, homozygous for the autosomal lymphopenia (Lyp) gene (Lyp/Lyp), heterozygous (Lyp/+), or wild-type (+/+), were immunized with the T cell-dependent bacteriophage PhiX174 to determine effects of Lyp on primary and secondary antibody responses. The primary PhiX174 antibody response did not differ between the three different genotypes. In contrast, the secondary immune r
We have examined the short-term effects of three volatile anaesthetics, halothane, isoflurane and desflurane, on mucociliary activity in the rabbit maxillary sinus in vivo. Mucociliary activity was recorded photoelectrically and the signal processed by fast Fourier transformation. Administration of 1.0 MAC of halothane, isoflurane or desflurane caused a temporary increase in mucociliary activity,
On this page you will find important information about things you should be aware of before, during and after your stay abroad. Please note that this is not an exhaustive list. You will also need to look for information elsewhere. Shortcuts to page content:Important preparations before departureWhile you are awayAfter your return Important preparations before departureAs an outgoing student, you m
Age-associated B cells (ABCs) are a novel subtype of B cells that accumulate with ageing, during infection, and in the progression of autoimmune diseases. Still, their exact phenotype and effector functions remain unknown. In this thesis, we aimed to provide an immunological characterisation of human ABC subsets by phenotyping them before and after in vitro stimulation and evaluating the alteratio
Characterizing the effect of pesticides on pollinators is essential in the strive to protect biodiversity while maintaining efficient food production. Metabolomics offers detailed insight into the physiological response to pesticides. The impact of pre-dissection and dissection methodology on the metabolic response remains largely unknown, as does their possible effect on the measured metabolic re
Discussion Brief No. 6 The right to a healthy environment in Southeast Asia National Prosecutors and Prosecuting Authorities The right to a healthy environment in Southeast Asia National Prosecutors and Prosecuting Authorities Discussion Brief No. 6 October 2021 The Raoul Wallenberg Institute of Human Rights and Humanitarian Law (RWI) discussion brief series, ‘The right to a healthy environment in
https://rwi.lu.se/wp-content/uploads/2024/06/Discussion-Brief-R2HE-6-Prosecutors.pdf - 2026-07-10
Store-operated Ca2+ entry (SOCE) is the major route of Ca2+ influx in platelets. The Ca2+ sensor stromal interaction molecule 1 (STIM1) triggers SOCE by forming punctate structures with the Ca2+ channel Orai1 and the inositol trisphosphate receptor (IP3R), thereby linking the endo-/sarcoplasmic reticulum to the plasma membrane. Here, we identified the BAR domain superfamily member bridging integra
