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Purpose s: The research aim is to develop a better design of auditory alerts that can improve air traffic controllers’ situation awareness. Method Participants are seventy-seven qualified Air Traffic Controllers. The experiment was conducted in the Air Traffic Control operational rooms of the Irish Aviation Authority at Shannon and Dublin. Participants were advised that the trials were in relation
Regime shifts in lake ecosystems can occur in response to both abrupt and continuous climate change, and the imprints they leave in paleolimnological records allow us to investigate and better understand patterns and processes governing ecological changes on geological time scales. This synthesis investigates paleolimnological records that display apparent regime shifts and characterizes the shift
Over the past 50 years, the concept existential question has played a less prominent role in upper secondary school curricula. The interpretation of the world view perspective has been retained until the curriculum 2000. Perspectives of personal development and interpretation of life in upper secondary school have almost disappeared. The syllabus has been content centred, reflective and analytical
A combination therapy approach is required to improve tumor immune infiltration and patient response to immune checkpoint inhibitors that target negative regulatory receptors. Galectin-3 is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and whose expression correlates with poo
Aims/hypothesis. We assessed how the role of genes genetic causation in causing maturity-onset diabetes of the young (MODY) alters the response to an oral glucose tolerance test (OGTT). Methods. We studied OGTT in 362 MODY subjects, from seven European centres; 245 had glucokinase gene mutations and 117 had Hepatocyte Nuclear Factor-1 alpha (HNF-1alpha) gene mutations. Results. BMI and age were si
In the present study, expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in rat dorsal root ganglion (DRG) neurons and sciatic nerve following experimental sciatic nerve compression was studied with the use of quantitative immunohistochemistry and in situ hybridization. Previously, we have investigated changes in PACAP expression after nerve transection and, here, the far mor
Treatment with omeprazole, a long-acting proton pump inhibitor of acid secretion, induces hypergastrinemia. In chickens, omeprazole induces growth not only of the acid-producing mucosa (probably reflecting the trophic action of gastrin), but also of the parathyroid glands (hypertrophy + hyperplasia), while suppressing bone density and body weight gain without affecting blood calcium. The first par
The presence of genes encoding organellar proteins in different cellular compartments necessitates a tight coordination of expression by the different genomes of the eukaryotic cell. This coordination of gene expression is achieved by organelle-to-nucleus communication. Stress-induced perturbations of the tetrapyrrole pathway trigger large changes in nuclear gene expression. In order to investigat
Klimatförändringar har amplifierats sedan den industriella revolutionen och modeller pekar på att förändringen kommer forsätta att öka åtminstone till slutet av detta århundrande. Globala temperaturer och nederbörd förväntas öka avsevärt under detta århundrade. Dessa ökningar förväntas bli särskilt markanta i de arktiska områdena. Torvmyrar belägna på höga latituder vid 0ºC isothermen, såsom StorfThe rate of change of our climate has been amplified since the industrial revolution and is expected to change even further by the end of this century. Global temperature and precipitation are expected to increase considerably over the next century. These increases are expected to be magnified in the Arctic regions. In a high latitude peatland like Storflaket, near Abisko (Northern Sweden), at the
Extensive genetic and epigenetic variegation has been demonstrated in many malignancies. Importantly, their interplay has the potential to contribute to disease progression and treatment resistance. To shed light on the complex relationships between these different sources of intra-tumour heterogeneity, we explored their relative contributions to the evolutionary dynamics of Acute Lymphoblastic Le
This study aims to investigate a potential convergence between the Green and Liberal parties of Europe regarding cultural issues of the GAL-TAN-scale, such as the environmental issue in particular. The focus on this issue is inspired by the increased debate and focus on the issue in relation to the 2019 European Parliament elections and by the theory of issue entrepreneuring strategies of the Gree
Objectives To identify the arthritogenic B cell epitopes of glucose-6-phosphate isomerase (GPI) and their association with rheumatoid arthritis (RA). Methods IgG response towards a library of GPI peptides in patients with early RA, pre-symptomatic individuals and population controls, as well as in mice, were tested by bead-based multiplex immunoassays and ELISA. Monoclonal IgG were generated, and
This dissertation investigates how different regions are financially integrated with the US capital markets and how the level of integration has changed over time. The research has been conducted by using an event study methodology to examine the impact on domestic stock prices following foreign cross-listings on US stock exchanges. A sample of 556 ADR programs initiated by companies from 38 count
Neuropeptide Y (NPY) is a powerful vasoconstrictor in vivo but is usually much less active on isolated blood vessels. The contractile effect of NPY was examined in the isolated rat femoral artery exposed to various degrees of vasoconstriction. The effects of NPY on the relaxation induced by vasodilator agents was also studied. NPY (< or = 1 microM) had no contractile effect. In vessels pretreated
The central aim of this thesis is to derive, implement and test new methods to calculate various types of spectroscopies of compounds containing heavy elements in an aqueous environment. Methods that can target such systems have to consider the following:(i) It is crucial to take relativistic effects into account.(ii) Modeling of larger systems is expensive in quantum chemistry. Thus, cheaper opti
