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Fetal and neonatal alloimmune thrombocytopenia (FNAITP) is a life-threatening bleeding disorder caused by maternal antibodies directed against fetal platelet antigens. The immunoreactive epitopes in FNAITP are primarily located in the extracellular regions of the platelet glycoprotein IIIa (β3 integrin). Here we have established a novel animal model of FNAITP using β3 integrin-deficient (β3-/-) mi
Popular Abstract in Swedish Respirationen i både växter och djur kan delas upp i tre delar: glykolysen, citronsyracykeln och elektrontransportkedjan. Glykolysen sker i cytoplasman (cellvätskan), medan citronsyracykeln och elektrontransportkedjan verkar i mitokondrierna. Mitokondrier fungerar som cellernas motorer. De är ungefär lika viktiga för cellen som motorn är för en bil. Mitokondrierna är smThe respiratory chain of plants contains class 2 NAD(P)H dehydrogenases, not present in animals. The functional roles of these enzymes have been elusive for a long time. Two cDNAs, homologous to class 2 NADH dehydrogenase genes of yeast and E. coli, were isolated from potato leaves. The gene products, NDA1 and NDB1, were shown to reside on the internal and external sides of the inner mitochondrial
The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where it is highly toxic for pericytes, mural cells that have contractile properties and regulate capillary
In a systematic examination of scales commonly used in L2 Motivational Self System (L2MSS) research, Al-Hoorie et al. (2024) found discriminant validity problems. Raising jangle fallacy concerns, they argue that substantive research should be paused until validity issues are ironed out. However, validity at the measurement level is dependent on validity at the construct level. Replication attempts
Road verges can support high densities of flowers and could therefore provide new opportunities for the conservation of flower-visiting insects. One way of optimizing road verges for vascular plant diversity is to adjust mowing regimes, but to date it is unclear how this affects flower-visiting insects. Furthermore, for mobile organisms like wild bees and butterflies, there is a risk that the bene
Background and objective: The treatment landscape of metastatic prostate cancer (mPCa) has evolved significantly over the past two decades. Despite this, the optimal therapy for patients with mPCa has not been determined. This systematic review identifies available predictive models that assess mPCa patients’ response to treatment. Methods: We critically reviewed MEDLINE and CENTRAL in December 20
This study aimed to experimentally examine how riverbed drying and different rates of water level reduction influenced the vertical movement of amphipods of various sizes into different subsurface sediment compositions. Using sediment columns (mesocosms) filled with different sized transparent substrates, we explored how varying speeds of drawdown affected vertical movement and stranding of indivi
PURPOSE: Fibromyalgia (FM) is a complex pain condition, and exercise is considered the first option of treatment. Few studies have examined the effect of exercise on molecular mechanisms in FM. The aim of this study was to analyze the plasma proteome in women with FM and healthy controls (CON) before and after 15 wk of resistance exercise. This study further investigated whether clinical and exerc
In an experimental study of humans reactions to social motor intention (SMI) in a humanoid robot, we showed that SMI cause the emergence of social interaction between human and robot. We investigated whether people would respond differently to a humanoid robot depending on the kinematic profile of its movement. A robot placed a block on a table in front of a human subject in three different ways.
The effects of N iodoacetyl 2 amino 2 deoxy (D) glucose and various N bromoacetylglycosylamines on the release of insulin from microdissected pancreatic islets of non inbred ob/ob mice were studied. N Bromoacetyl β (D) glucosylamine (10 m(M)) initiated insulin release in the absence of (D) glucose and, at concentrations of 2.5-10 m(M), but not 20 m(M), potentiated insulin release in response to 10
Increased intraocular pressure (IOP) is a major risk factor for glaucoma, and its contribution to neuronal damage appears multi-factorial. An open issue is whether pressure effects on blood vessels contribute to neuronal damage. In particular, little is known about pressure effects on capillaries, which are the site of most metabolic exchange in the retina, but cannot be easily visualized in vivo.
We here respond to the critique by Purdon of an article on carbon forestry that we published in this journal last year (Carton and Andersson). While we welcome critical engagements with our work, Purdon’s argument is wide of the mark and appears based largely on misconceptions regarding our theoretical entry point and empirical findings. Underlying this are fundamental disagreements about the natu
Allergic diseases affect many individuals world-wide and are dependent on the interaction between allergens and antibodies of the IgE isotype. Allergen-specific immunotherapy (AIT) can alter the development of the disease, e.g., through induction of allergen-specific IgG that block allergen-IgE interactions. The knowledge of epitopes recognized by allergy-causing and protective antibodies are limi
