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Enhancing forest drought resilience is important for preserving ecosystem services in the face of climate change, but operational management methods for boreal forests aiming to preserve ecosystem services under drought are still largely missing. This study explores the use of satellite remote sensing to monitor vegetation stress phases related to drought progression and to quantify both short- an
The MentLife mentorship program aims to support young researchers interested in a career within life science industry. The program was founded in 2013 by Lars Erik Edholm and is since 2019 organized by the Careers Center at the Faculty of Medicine at Lund University. Mentor Helen Sjögren and mentee Diahann Atacho share their experiences from the program. Helen Sjögren, Senior Principal Scientist a
The length of the polymorphic CAG repeat in the N-terminal of the androgen receptor (AR) gene is inversely correlated with the transactivation function of the AR. Some studies have indicated that short CAG repeats are related to higher risk of prostate cancer. We performed a case-control study to investigate relations between CAG repeat length and prostate cancer risk, tumour grade, tumour stage,
OBJECTIVE: To identify factors predicting response to first TNF blocking treatment course in patients with established RA with a special focus on gender differences. METHODS: Patients with active RA initiating their first treatment course of TNF-blocking therapy were enrolled. The study period was March 1999 through September 2006. The prospective protocol included information on demographics, cli
Recently, common noncoding variants in the TCF7L2 gene were strongly associated with increased risk of type 2 diabetes in samples from Iceland, Denmark, and the U.S. We genotyped 13 single nucleotide polymorphisms (SNPs) across TCF7L2 in 8,310 individuals in family-based and case-control designs from Scandinavia, Poland, and the U.S. We convincingly confirmed the previous association of TCF7L2 SNP
Trade-offs between immune function and other physiological and behavioural processes are central in ecoimmunology, but one important problem is how to distinguish a reallocation of resources away from the immune system from a reallocation or redistribution within the immune system. While variation in baseline values of individual immune parameters is well established, studies in wild animals on mu
Wetlands are integral components of our natural environment since they provide many critical ecosystem services to humanity, such as water purification, climate change mitigation, flood control, and biodiversity. Although wetlands can convey resilience to some degree of changes, they might be vulnerable to climate change. Altered hydrology and rising temperatures can turn the wetland services into
The humoral immune response to human cytomegalovirus (CMV) membrane glycoprotein gp58/116 (gB) has been studied by establishing cell lines producing specific human monoclonal antibodies. These cell lines were generated from peripheral blood lymphocytes obtained from a healthy carrier. Hybridomas producing gp58/116-speciftc antibodies were detected by reactivity to procaryotically expressed protein
By use of a batch microcalorimeter of the thermopile type, heat production was measured in isolated populations of human peripheral blood cells exposed to defined immune complexes formed in vitro. It was found that most of the heat production recorded in whole blood after admixture of immune complexes occurs in the granulocytes. Under these conditions small but constantly higher activation values
To increase our understanding of long-term climate dynamics and its effects on different ecosystems, palaeoclimatic and long-term botanical reconstructions need to be improved, in particular in underutilized geographical regions. In this study, vegetation, (hydro)climate, and land-use changes were documented at two southeast Lithuanian peatland complexes – Čepkeliai and Rieznyčia – for the Late-Ho
Background: Pneumococcal vaccination is recommended to patients with rheumatoid arthritis (RA) and primary Sjögren’s syndrome (pSS). However, little is known whether the diseases influence pneumococcal vaccine response. This study aimed to investigate antibody response and functionality of antibodies following immunization with 13-valent pneumococcal conjugate vaccine (PCV13) in RA patients or pSS
Background: Calcitonin gene-related peptide (CGRP) is one of the most potent endogenous vasodilators identified to date. The present study elucidates the differential interaction of CGRP, its receptor and the effect of the CGRP-receptor antagonist telcagepant on intracellular Ca2+ -levels and tension in rat middle cerebral arteries (MCA) by pressurized arteriography, FURA-2/wire myography and immu
Holocene records of cellulose-inferred lake-water delta O-8 were produced from two lake-sediment sequences obtained in central and northern Kamchatka, Russian Far East. The sediment records share similar fluctuations in delta O-8 during the interval of ca. 5000-800 cal yr BP that correspond (inversely) with changes in K+ content of the GISP2 ice-core record from Greenland, a proxy for the relative
