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Background We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma. Methods EURAMOS-1 was an open-label, international, phase 3 randomised, controlled trial. Consenting patients with newly diag
Rationale: We recently demonstrated that patients with coronary artery disease (CAD) and obstructive sleep apnea (OSA) carrying the tumor necrosis factor-alpha (TNF-α) A allele had increased circulating TNF-α levels compared with the ones carrying the TNF-α G allele. In the current study, we addressed the effect of TNF-α (-308G/A) gene polymorphism on circulating TNF-α levels following continuous
The aim of this study was to examine whether autoantibodies to: ZnT8-Tryptophan (ZnT8WA), ZnT8-Arginine (ZnT8RA) or ZnT8-Glutamine (ZnT8QA) correlated with C-peptide or other autoantibodies and to assess diagnostic sensitivity of ZnT8WRQA. Specimens from 270 newly diagnosed diabetic subjects (age 15--34 years) and after five 5 years duration of disease were examined. Four linear regression models
Background: Saturated fat (SFA) has consistently been shown to increase liver fat, but the response appears variable at the individual level. Phenotypic and genotypic characteristics have been demonstrated to modify the hypercholesterolemic effect of SFA but it is unclear which characteristics that predict liver fat accumulation in response to a hypercaloric diet high in SFA. Objective: To identif
Isla de los Estados (54A degrees 45'S, 63A degrees 10'aEuro"64A degrees 46'W) lies east of the main island of Tierra del Fuego and is the southeastern-most point in Argentina. Because of its geographic position near the latitudes of the Southern Hemisphere Westerlies and the strong influence of the Antarctic Circumpolar Current (ACC), the area is suitable for paleoecological and paleoclimate resea
In the newly founded state Kosovo, the women’s rights movement has become a strong voice on gender equality and contributes in important ways to strengthening women’s rights. At the same time, highly gendered political structures restrict the movement’s access to political influence. The purpose of this thesis is to explore how the political opportunities and challenges that the movement faces hav
Introduction: Immune checkpoint inhibitors (ICIs) have transformed lung cancer treatment, yet their effectiveness seem restricted to certain patient subsets. Current clinical stratification on the basis of programmed death ligand 1 (PD-L1) expression offers limited predictive value. Given the mechanism of action, directly detecting spatial programmed cell death protein 1 (PD1)–PD-L1 interactions m
BACKGROUND: The mechanism behind the antiviral action of interferon (IFN) therapy in chronic hepatitis C virus (HCV) infection is not well understood, and, furthermore, few factors have been shown to be good predictors of a favourable response to IFN treatment in chronic HCV infection. METHODS: Freshly explanted liver cells and peripheral blood mononuclear cells (PBMC) from 80 patients with chroni
Introduction: This study aimed to investigate the dose-response and pharmacology of a range of single doses of nebulised ensifentrine (RPL554), an inhaled dual phosphodiesterase (PDE) 3/4 inhibitor in patients with asthma. Methods: In this randomised, placebo-controlled, double-blind crossover study, patients received single nebulised doses of ensifentrine 0.4, 1.5, 6 and 24 mg, salbutamol 2.5 and
Since 1978, China has experienced a series of economic reforms, transitioning from a centrally planned economy to a liberal market economy. Correspondingly, the economic transformation has left a profound impact on the health care system. Universal free health care provided by state-owned enterprises was gradually replaced by modern social medical insurance schemes. The government dramatically dec
The English present perfect and simple future tenses are felicitous with the living, but not the dead, as a referent must exist at reference time. In contrast, the simple past is odd with living referents in out-of-the-blue statements, as it requires a specified or implied past reference time. We employed eye-tracking during reading (Experiment 1) and self-paced reading (Experiments 2 and 3) in or
I forskargruppen studerar vi val av kirurgisk metod vid primär bröstcancerkirurgi (LR), riskfaktorer för lokalrecidiv (ENM) och rehabiliteringsbehov (MM/LR) efter primär kirurgi. Genom att systematiskt analysera sambandet mellan lymfkörtelmetastas och patient- och tumörrelaterade faktorer avser vi att ta fram ett kliniskt beslutsstöd som kan användas för att skräddarsy axillens kirurgi. Projektet
