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Implementing injury prevention training in youth handball (I-PROTECT) in Sweden: Study protocol for a cluster-randomized trial

Introduction Efficacy trials show that evidence-based injury prevention training reduces injuries in youth athletes but effectiveness, that is, outside the controlled setting, is lower and, consequently this training has had limited public health impact. Insufficient involvement of end-users at the individual and organisational levels is identified as a main barrier to successful implementation. T

A proposed medical system change in Japan inspired by Swedish primary health care : Important role of general practitioners and specialist nurses at primary health care centers

Japanese citizens of all socioeconomic statuses have benefited from the national insurance system by receiving high-quality healthcare. However, the Japanese healthcare service is facing a severe financial crisis because of the increasing aging society and social security expenses. Many consultations raise medical expenditure and doctors' work overload, which is about to be regulated, but is quest

Low-Dose Morphine Does Not Cause Sleepiness in Chronic Obstructive Pulmonary Disease : A Secondary Analysis of a Randomized Clinical Trial

Rationale: Regular, low-dose, sustained-release morphine is frequently prescribed for persistent breathlessness in chronic obstructive pulmonary disease (COPD). However, effects on daytime sleepiness, perceived sleep quality, and daytime function have not been rigorously investigated. Objectives: We sought to determine the effects of regular, low-dose, sustained-release morphine on sleep parameter

Sex ratio at birth across 100 years in Sweden and risk of cardiovascular disease and all-cause mortality – a national register study

The human sex ratio at birth (SRB) undergoes temporary changes around a mean proportion of 0.51 male births. SRB has been well studied for historical, geographical, and secular trends, but until now not linked to health outcomes in the total population, e.g. for cardiovascular disease (CVD) or mortality during follow-up of birth cohorts. We used linkage analysis based on national registers in Swed

Breathing techniques to reduce symptoms in people with serious respiratory illness : a systematic review

Background In adults with serious respiratory illness, breathlessness is prevalent and associated with reduced health-related quality of life. The aim of this review was to assess the impact of breathing techniques on breathlessness in adults with serious respiratory illness. Methods Electronic databases were searched to identify randomised controlled trials testing breathing techniques (technique

Stimuli-responsive drug delivery systems for inflammatory skin conditions

Inflammatory skin conditions highly influence the quality of life of the patients suffering from these disorders. Symptoms include red, itchy and painful skin lesions, which are visible to the rest of the world, causing stigmatization and a significantly lower mental health of the patients. Treatment options are often unsatisfactory, as they suffer from either low patient adherence or the risk of

Flight activity and effort of breeding pied flycatchers in the wild, revealed with accelerometers and machine learning

Flight behaviours of birds have been extensively studied from different angles such as their kinematics, aerodynamics and, more generally, their migration patterns. Nevertheless, much is still unknown about the daily foraging flight activity and behaviour of breeding birds, and potential differences among males and females. The recent development of miniaturized accelerometers allows us a glimpse

Is the shift in treatment patterns toward new, more expensive drugs still driving the increase in pharmaceutical expenditure? : A decomposition analysis of expenditure data in Sweden 1990-2022

BACKGROUND: Pharmaceutical expenditures (PE) are increasing worldwide raising concerns about sustainability. However, the current price index provides an incomplete picture of this trend due to the rapid introduction of new drugs on the market.OBJECTIVE: The aim of this study is to decompose PE into their components and investigate the development in Sweden from 1990 to 2022.METHODS: The PE index

Prenatal exposure to endocrine disrupting chemicals and the association with behavioural difficulties in 7-year-old children in the SELMA study

Background: Endocrine disrupting chemicals (EDCs) can cross the placenta and thereby expose the fetus, which may lead to developmental consequences. It is still unclear which chemicals are of concern regarding neurodevelopment and specifically behaviour, when being exposed to a mixture. Objective: The objective is to determine associations between prenatal exposure to EDCs and behavioural difficul

The course of plasma alpha-1-microglobulin and haemolysis during cardiac surgery and the relationship to acute kidney injury, a pilot study

Haemolysis occurring during cardiac surgery with cardiopulmonary bypass (CPB) is assumed to be a risk factor for postoperative acute kidney injury (AKI). Plasma alpha-1 microglobulin (A1M) may have a protective role as haem scavenger. The aim of this study was to evaluate the association between AKI and the degree of haemolysis and the course of A1M concentrations during cardiac surgery, respectiv

Extending the Lund-Malmö creatinine-based GFR equation to cystatin C–validation results from the European Kidney Function Consortium (EKFC) cohort of children and adults

The aim of the present study was to extend the creatinine-based Lund-Malmö GFR equation for use with rescaled cystatin C (r-LMRCys) and validate it against measured GFR (mGFR) in the EKFC cystatin C cohort of children (n = 2,293) and adults (n = 7,727). Rescaling was obtained by dividing each biomarker by a Q-value, representing the population-specific median biomarker level among healthy individu

Internal marketing in changing times - Supporting personnel meeting customers in physical retail stores

Abstract NRWC 2024 Internal marketing in changing times - Supporting personnel meeting customers in physical retail storesUlf Johansson, Lund School of Economics and management, Center for retail studies at Lund universityKristina Bäckström, Campus Helsingborg, Lund university, Center for retail studies at Lund universityA lot has been written about the change of retail in later years (Berman, 201

Childhood neighborhoods and health in later Life : Hospital admissions in Sweden 1939-2015

We study the association between childhood neighborhood socioeconomic status (SES) (ages 1-15) and hospitalization with preventable-type disease in adulthood, using geocoded longitudinal microdata for a Swedish city (1939-1967) linked to national registers (1973-2015). Observing the full residential histories at the address level for the entire population, we construct dynamic and cumulative indiv

Prognostic Testing for Prostate Cancer—A Cost-Effectiveness Analysis Comparing a Prostatype P-Score Biomarker Approach to Standard Clinical Practice

Background: The Prostatype score (P-score) is a prognostic biomarker that integrates a three-gene (IGFBP3, F3, and VGLL3) signature derived from prostate biopsy samples, with key clinical parameters, including prostate-specific antigen (PSA) levels, Gleason grade, and tumor stage at diagnosis. The test has demonstrated superior predictive accuracy for prostate cancer outcomes compared with traditi

Incidence of Clinically Diagnosed Psoriatic Arthritis in Sweden

Objective. Prior incidence estimates of psoriatic arthritis (PsA) vary considerably. We aimed to assess the annual incidence of clinically diagnosed PsA among adults in Sweden in 2014-2016, overall and stratified by age/sex/education/geography, and to investigate potential time trends in incidence in 2006-2018. Use of disease-modifying antirheumatic drugs (DMARDs) during the 2 years after diagnosi

Sun Exposure and Type 2 Diabetes Mellitus : A Prospective Follow-up Cohort Study from Southern Sweden

Background/Aim: An inverse association exists between type 2 diabetes mellitus (T2DM) and both plasma vitamin D levels and sun exposure, but vitamin D supplementation does not reduce the incidence. We sought to assess whether there is a dose-dependency in the association between sun exposure and T2DM. Patients and Methods: The melanoma in Southern Sweden (MISS) cohort is comprised of one thousand