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Genetic and non-genetic factors probably act together to initiate and accelerate development of type 1 diabetes [T1D]. One suggested risk factor contributing to development of T1D is air pollution.

Swedishness, Catholicism and European IntegrationThe position of the Catholic Church in Sweden has radically changed in the last forty years. At the beginning of the 1960s, the Catholicism was commonly regarded as a threat to Swedish cultural identity, not least among members of the ruling Social-Democratic Party. Today, the Catholic Church is an accepted part of Swedish society. In my article, I The position of the Catholic Church in Sweden has radically changed in the last forty years. At the beginning of the 1960s, the Catholicism was commonly regarded as a threat to Swedish cultural identity, not least among members of the ruling Social-Democratic Party. Today, the Catholic Church is an accepted part of Swedish society. This article discuss this process of change and its impact on Swed

Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activi

A numerical method for the transient moisture flow in porous cellulosic materials like paper and wood is presented. The derivation of the model is based on mass conservation for a mixture containing a vapour phase and an adsorbed water phase embedded in a porous solid material. The principle of virtual moisture concentrations in conjunction with a consistent linearization procedure is used to prod

A matched filter composed of a time lagged feedforward artificial neural Network (TLFN) and a pulse-shaping filter is used in a noisy environment to detect R-waves for pacemakers. The TLFN reduces the influence of lower frequencies in the invasive electrogram (EGM) signals, e.g. P and T waves, and conditions the EGM to optimize the performance of the dynamically updated matched filter. Detector pe

Our aims were to investigate possible associations between hospitalisation for venous thromboembolism (VTE) and socioeconomic and occupational factors. A nationwide database was constructed by linking Swedish census data to the Hospital Discharge Register (1990-2007). Hospital diagnoses of VTE were based on the International Classification of Diseases. Standardised incidence ratios were calculated

The European Green Deal (EGD) aims for agriculture to contribute positively to climate change mitigation and nature preservation while meeting growing societal needs for food, energy, and biomaterials. Delivering comprehensive policy action efficiently requires decision-support tools to assess the outcomes of interventions across multiple, and potentially conflicting, goals. By means of agent-base

Post-compression of (sub)-picosecond laser pulses down to sub-100 fs durations has become a standard approach for high-peak-power sources at a high average power [1]. Here, we propose a new post-compression geometry suited for extreme temporal compression of energetic narrowband lasers, such as diode or electrically pumped four-level systems which can deliver kW-average powers [2], but typically e

As the total cost of renewable electricity falls lower than the price of fossil fuel, not only can electricity be used to replace fossil fuels using batteries in vehicles but it can also be used to produce fuels. This makes it possible to replace fuels in sectors not easily directly electrified. It also provides new ways of balancing the electricity system. When renewable electricity is cheap a lo

Peripheral nerve tumours, most commonly schwannomas and neurofibromas, might present significant challenges by eliciting physical symptoms and emotional distress. We aimed to explore patients’ expectations, perceptions, and experiences regarding their diagnosis and the surgical treatment of a nerve tumour in the upper limb. Fourteen adults (10 women, 4 men; age range 35–85) from two Swedish hand s

Dopaminergic neurons in the ventral midbrain are critical for regulating movement, cognition, and emotion. Ventral midbrain organoids can be used to model both development and diseases of the dopaminergic system, especially Parkinson’s disease. Here, we summarize recent advances and remaining challenges in developing such three-dimensional organoids from human pluripotent stem cells. We outline ho

Solar-driven hydrogen production stores renewable energy chemically but suffers from efficiency limitations due to the slow hole transport-dominated recombination, which caused by high valence band degeneracy and hole effective mass. Targeted hole trap regulation is essential to minimize these losses and enhance photocatalytic H2 evolution performance for practical applications. This study address

Background: The 313-variant polygenic risk score (PRS313) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS313 across different European populations which could influence risk estimation has not been performed. Methods: We explored the distribution of PRS313 across European populations using genotype data from 94,072 females without breast cancer

Neuroblastoma (NB) is a heterogeneous childhood cancer, characterized by the amplification of the MYCN oncogene in 40% of the high-risk cases. Our previous work demonstrated that MYCN drives metabolic reprogramming in NB, including upregulation of antioxidant enzymes. Here, we identify peroxiredoxin 6 (PRDX6) as a promising therapeutic target in NB. Pharmacological inhibition of PRDX6 reduces MYCN

Epitaxially grown nanowires have shown promise for photovoltaic applications due to their nanophotonic properties. Moreover, the mechanical properties of nanowires can reduce crystallographic defect formation at interfaces to help enable new material combinations for photovoltaics. One material that stands to benefit from the nanowire morphology is zinc phosphide (Zn3P2), which, despite promising

We face closely intertwined crises related to biodiversity, climate change, global health andinequality. Unfortunately, the knowledge that could help overcome these existential crises isscattered across millions of scientific articles, reports, policy documents, databases, andindividual datasets, far exceeding human processing capabilities. This hinders evidence-basedresearch, innovation and polic

Analyzing kinetic experiments on protein aggregation using integrated rate laws has led to numerous advances in our understanding of the fundamental chemical mechanisms behind amyloidogenic disorders such as Alzheimer's and Parkinson's diseases. However, the description of biologically relevant processes may require rate equations that are too complex to solve using existing methods, hindering mec