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Consider a reflected random walk Wn+1 = (W-n +X-n)(+), where X-o, X-1,... are i.i.d. with negative mean and subexponential with common distribution F. It is shown that the probability that the maximum within a regenerative cycle with mean mu exceeds x is approximately mu (F) over bar(x) as x --> infinity, and thereby that max (W-o,..., W-n) has the same asymptotics as max(X-o,...,X-n) as n --> inf

Soft-input/soft-output symbol decoding plays a significant role in iterative decoding. We propose a simple optimal soft-input/soft-output symbol decoding algorithm for linear block codes which requires one forward recursion using a trellis. For many codes the decoding complexity is lower than previous methods, such as the algorithm by Bahl et al. (1974), and the decrease is shown at its most when

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GR

Background The pattern of cancer in long-term survivors from childhood cancer has not been investigated comprehensively. Methods We obtained a cohort of 47 697 children and adolescents aged 0-19 years with cancer as defined by the country-wide cancer registries of Denmark, Finland, Iceland, Norway, and Sweden during 1943-2005. Cohort members were followed through age 79 years for subsequent primar

Dopamine (DA) neurons derived from human embryonic stem cells (hESCs) are potentially valuable in drug screening and as a possible source of donor tissue for transplantation in Parkinson's disease. However, existing culture protocols that promote the differentiation of DA neurons from hESCs are complex, involving multiple steps and having unreliable results between cultures. Here we report a simpl

This paper presents an innovative research on urban risk reduction and climate change adaptation that combines case studies, grounded theory and systems analysis, which could be used as a template for similar intersectoral and interdisciplinary investigations. Such a ‘case studies–grounded theory–systems analysis approach’ permits a grounded theory to be built from case study data, which is viewed

Given an electronic wave function, generated by the MCHF program (LS format) or the MCHF_CI program (LSJ format), this program computes the hyperfine interaction constants, A(J) and B(J). In strong experimental magnetic fields, the splitting is also affected by the off-diagonal hyperfine constants A(J,J-1), B(J,J-1), and B(J,J-2) and these are computed as well, depending on the input data.

Liver microcirculation can be affected by a wide variety of causes relevant to liver transplantation and resectional surgery. Intraoperative assessment of the microcirculation could possibly predict postoperative outcome. The present pilot study introduces laser speckle contrast imaging (LSCI) as a new clinical method for assessing liver microcirculation.

The ambiguity domain plays a central role in estimating the time-varying spectrum of a non-stationary random process in continuous time, since multiplication in this domain is equivalent with estimating the covariance function of the random process using an intuitively appealing estimator. For processes in discrete time there exists a corresponding covariance function estimator. The ambiguity doma

Objective. Serum calcium concentrations have been associated with the risk of malignant disease, especially breast cancer. Thus, determinants of serum calcium concentrations, with special regard to risk factors of breast cancer, are of great interest. Material and methods. Previous studies have either been small or they have not focused on reproductive factors. The present study examined serum cal

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In this study, we analysed the ease of use of three computer programs for self-registration of job seekers. The programs were developed in somewhat different activity contexts. The differences found between the programs in two experiments appeared to result from a combination of fewer constraints on individual input demanded by Job Seeker Bank and Af Explore and from the programs’ better adaptatio

Weak convergence of the multivariate point process of upcrossings of several high levels by a stationary Gaussian process is established. The limit is a certain multivariate Poisson process. This result is then used to determine the joint asymptotic distribution of heights and locations of the highest local maxima over an increasing interval. The results are generalized to upcrossings and local ma

Aims: To examine whether the socio-economic determinants of alcohol use found in high-income university student settings are also true of Uganda. Design: Two cross-sectional surveys, conducted in 2005 and 2010, combined into a single dataset. Setting: Mbarara University of Science and Technology (MUST) in southwestern Uganda. Participants: 2,934 students (N in 2005 = 980; N in 2010 = 1,954). To

Echocardiography has a vital role for diagnosing and monitoring infectious endocarditis. The recently published Swedish guidelines for diagnosis and treatment of infectious endocarditis recommend overuse of transoesophageal echocardiography, which is not supported by the literature. The European Society of Cardiology presents a considerably more appropriate opinion.

Conclusion Sentinel lymph node biopsies (SLNBs) can be performed safely and with reasonable accuracy in HNM patients. The outcome provides important prognostic information concerning DFS and further treatment. However, one must recognize that SLNB is a multidisciplinary procedure with a learning curve for all. Objectives To evaluate efficacy of performing SLNBs in a series of consecutive patients

Gas phase polyethylene reactors are able to produce several different grades of polymer. Adapting to market conditions requires grade transitions, associated with costs in terms of raw material and temporary production of lower priced off-specification products. In this paper, both stationary production and dynamic grade transitions are optimized to maximize profit, i.e., economic process optimiza