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AIMS/HYPOTHESIS: Impaired glucose tolerance and impaired insulin secretion have been reported in families with PAX6 mutations and it is suggested that they result from defective proinsulin processing due to lack of prohormone convertase 1/3, encoded by PCSK1. We investigated whether a common PAX6 variant would mimic these findings and explored in detail its effect on islet function in man. METHODS
Incidence of cancer of unknown primary (CUP) varies globally, and environmental factors are suspected to be related to its development. Immigrant studies offer insights into disease etiology, but no studies have been published on CUP. We investigated CUP risk in immigrants to Sweden to search for etiological clues. The nationwide Swedish Family Cancer Database was used to calculate standardized in
The society of today is highly dependent on technical infrastructures. Several incidents around the world the last decades have clearly highlighted the major effects technical infrastructure breakdowns have on life, health and economy of society. The vulnerabilities inherent in our technical infrastructures must be addressed in a proactive manner; it is not feasible to wait for major incidents to
Methods to achieve admittance matching of rectangular dielectric resonator antennas intended for 60~GHz impulse radio are reported. The motivation is to find a suitable antenna that may be integrated in the V-band gated tunnel diode wavelet generator, replacing its tank circuit and forming a low complexity transmitter. Probed one- and two-port scattering parameter measurements have been performed
Recent contributions to the field of Resilience Engineering (RE) have added to the continuous development of new concepts and methodologies to improve resilience at different organisational levels. Part of these contributions has focused on training for adaptive capacity of individuals and teams to cope with changes and disturbances of work, since literature recognise that working tasks (at least
Introduction: The objective of this study was to describe the longitudinal cognitive outcome in Alzheimer’s disease (AD) and analyze factors that affect the outcome, including the impact of different cholinesterase inhibitors (ChEI). Methods: In an open, three-year, nonrandomized, prospective, multicenter study, 843 patients were treated with donepezil, rivastigmine, or galantamine in a routine cl
Values and opinions about what is valuable, are of centralimportance in risk and vulnerability analyses. Yet what is considered valuableis seldom explicitly established. The aim of this study is to explore what groupsof civil servants express as valuable and worth protecting when performing riskand vulnerability analyses in their organisations and to discuss the underlyingreasons for their stipula
Risk and Interdependencies in Critical Infrastructures Springer Series in Reliability Engineering 2012, pp 49-65 Modelling, Simulation and Vulnerability Analysis of Interdependent Technical Infrastructures Jonas Johansson, Henrik Hassel … show all 2 hide » Download Book (7 380 KB) As a courtesy to our readers, the eBook is provided DRM-free. However, please note that an invisible watermark has
