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Background: Musculoskeletal disorders are very common and almost inevitable in an individual's lifetime. Enabling self-management and allowing the individual to take responsibility for care is stated as desired in the management of these disorders, but this may be asking more than people can generally manage. A willingness among people to take responsibility for musculoskeletal disorders and not p
Perivascular adult stem cells have been isolated from several tissues, including the adult human brain. They have unique signatures resembling both pericytes and mesenchymal stem cells. Understanding the nature of these cells in their specific vascular niches is important to determine their clinical potential as a new adult stem cell source. Indeed, they have promising features in vitro in terms o
This Letter presents a search for a hidden-beauty counterpart of the X(3872) in the mass ranges of 10.05-10.31 GeV and 10.40-11.00 GeV, in the channel X-b -> pi(+)pi(-)gamma(1S)(-> mu(+)mu(-)), using 16.2 fb(-1) of root s = 8 TeV pp collision data collected by the ATLAS detector at the LHC. No evidence for new narrow states is found, and upper limits are set on the product of the Xb cross section
There is a growing scientific consensus that limiting the increase in global average temperature to around 2 C above pre-industrial levels is necessary to avoid unacceptable impact on the climate system. This requires that the developed countries' emissions are radically reduced during the next 40 years. Energy scenario studies provide insights on the societal transitions that might be implied by
Rheumatoid arthritis (RA) is a highly disabling disease affecting all structures of the joint. Understanding the pathology behind the development of RA is essential for developing targeted therapeutic strategies as well as for developing novel markers to predict disease onset. Several molecules normally hidden within the cartilage tissue are exposed to complement components in the synovial fluid u
A concept for time-sensitive optical detectors is described that shows how to confirm whether the detection device is operating in the linear response regime. By evaluating the recorded time decay of a thermographic phosphor, even weak saturation effects far from obvious situations can be identified and further related to either optical or electrical saturation. The concept has been validated by r
Assays detecting antigen (Ag)-specific T-cell responses in immune-mediated processes are increasingly employed to understand disease pathogenesis and "immune staging". The quantity and quality of starting peripheral blood mononuclear cell (PBMC) preparations are important factors in the performance of such assays. We therefore compared final PBMC yield and function by modifying parameters at the b
A means for noninvasive measurement of transverse and longitudinal characteristics of bunched beams in synchrotrons has been developed based on high sensitivity slotted waveguide pickups. The pickups allow for bandwidths exceeding hundreds of MHz while maintaining good beam sensitivity characteristics. Wide bandwidth is essential to allow bunch-by-bunch measurements by means of a fast gate. The Sc
The biothiols sensing mechanism of (E)-7-(diethylamino)-3-(2-nitrovinyl)-2H-chromen-2-one (DCO) has been investigated using the density functional theory (DFT) and time-dependent DFT methods. The theoretical results indicate that the excited-state intermolecular hydrogen bonding (H-B) plays an important role for the biothiols sensing mechanism of the fluorescence sensor DCO. Multiple H-B interacti
Background: Proteins can be used in drug delivery systems to improve pharmacological properties of an active substance. Differences in pH between tissues can be utilized in order to achieve a targeted drug release at a specific location or tissue, such as a tumor. The enamel matrix protein amelogenin has a pH dependent solubility profile and self-assemble to form aggregates at neutral pH. This cou
Molecularly imprinted (MIP) and blank polymers with affinity for nonylphenol were designed using computational modelling. Chromatographic tests demonstrated higher affinity of imprinted polymers towards the template nonylphenol as compared with blank polymers. The performance of both polymers in solid-phase extraction was however very similar. Both blank and imprinted polymers appeared to be suita
Background: Critical needs for treatment trials in gastroesophageal reflux disease (GERD) include assessing response to treatment, evaluating symptom severity, and translation of symptom questionnaires into multiple languages. We evaluated the previously validated Reflux Disease Questionnaire (RDQ) for internal consistency, reliability, responsiveness to change during treatment and the concordance
In 2003 the concept of Application Service Provision (ASP) as a way to provide Enterprise Systems (ES) to Small and Medium sized Enterprises (SMEs), “hyped”. In 2013 we saw the same “hype” but now with the Software as a Service (SaaS) model. Even if labelled differently, these concepts seem to mean the same and so, in this paper, we explore if providers perspective for the adoption of external pro
Popular Abstract in Swedish Adenovirus från människa (Ad) används ofta vid genterapi mot cancer, vaccinutveckling och genöverföring. Modifierade Ad5 och Ad2 virus har framgångsrikt använts som cancercelldödande (onkolytiska) agens i experimentella studier som dock inte kunnat överföras till kliniskt bruk av flera skäl, inklusive bristande spridning av virusinfektionen inom tumörvävnaden. De onkolyHuman adenoviruses (Ads) are broadly used in cancer gene therapy, vaccine development and gene delivery. The modified Ad5 or Ad2 viruses have been successfully used as oncolytic agents in pre-clinical studies. However they could not be translated into clinic utility due to a number of limitations including inefficient Ad spread among tumor cells. The cancer cell killing capacity of oncolytic Ad is
Use of wood feedstocks for sugar-based biorefineries requires suitable treatments of the various tree fractions to optimize yields. In the current study, stem wood fractions (sapwood, heartwood and knotwood) were sampled at different heights from well-documented Scots pine trees taken from two contrasting stands. The fractions were assessed in terms of chemical composition, response to SO2-catalys
An acoustophoresis-based microfluidic flow-chip is presented as a novel platform to facilitate analysis of proteins and peptides loosely bound to the surface of beads or cells. The chip allows for direct removal of the background surrounding the beads or cells, followed by sequential treatment and collection of a sequence of up to five different buffer conditions. During this treatment, the beads/
